Results 61 to 70 of about 20,238 (218)

A Need to Discover the World of Giant Viruses [PDF]

Intervirology, 2013
tion of microbes [2] . As a matter of fact, in the 20th century, some giant viruses were considered for a long time to be bacteria or parasites because the size factor biased their initial viral classification. Indeed, the established definition of a virus during the 20th century considered that all viruses should have at least one dimension of less ...
openaire   +2 more sources

Ubiquitous giants: a plethora of giant viruses found in Brazil and Antarctica [PDF]

Virology Journal, 2018
Since the discovery of giant viruses infecting amoebae in 2003, many dogmas of virology have been revised and the search for these viruses has been intensified. Over the last few years, several new groups of these viruses have been discovered in various types of samples and environments.In this work, we describe the isolation of 68 giant viruses of ...
Andrade, Ana Cláudia dos S. P., Arantes, Thalita S., Rodrigues, Rodrigo A. L., Machado, Talita B., Dornas, Fábio P., Landell, Melissa F., Furst, Cinthia, Borges, Luiz G. A., Ambrosio Leal Dutra, Lara, De Freitas Almeida, Gabriel, Trindade, Giliane de S., Bergier, Ivan, Abrahão, Walter, Borges, Iara A., Cortines, Juliana R., Oliveira, Danilo B. de, Kroon, Erna G., Abrahão, Jônatas S.   +17 more
openaire   +4 more sources

Genotype–Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins, Tiziano Pramparo, Chaowapong Jarasvaraparn, Michael J. Wilsey, Voytek Slowik, Lakshmi Kunam, Janis M. Stoll, Ruben E. Quiros‐Tejeira, Simon Lam, Wikrom Karnsakul   +9 more
wiley   +1 more source

Gene Exchange and the Origin of Giant Viruses

Intervirology, 2010
Giant viruses or nucleocytoplasmic large DNA viruses (NCLDVs) infect a wide range of eukaryotic hosts (including, algae, amoebae and metazoans) and show a very large range in genome size (between 100 kb and 1.2 Mb). Here we review some recent results concerning the extensive lateral gene transfer which appears to have occurred during NCLDV evolution ...
Jonathan, Filée, Michael, Chandler
openaire   +2 more sources

Diverse Trajectories Drive the Expression of a Giant Virus in the Oomycete Plant Pathogen Phytophthora parasitica

Frontiers in Microbiology, 2021
Giant viruses of amoebas, recently classified in the class Megaviricetes, are a group of viruses that can infect major eukaryotic lineages. We previously identified a set of giant virus sequences in the genome of Phytophthora parasitica, an oomycete and ...
Sihem Hannat, Sihem Hannat, Pierre Pontarotti, Pierre Pontarotti, Pierre Pontarotti, Philippe Colson, Philippe Colson, Philippe Colson, Marie-Line Kuhn, Eric Galiana, Bernard La Scola, Bernard La Scola, Sarah Aherfi, Sarah Aherfi, Sarah Aherfi, Franck Panabières   +15 more
doaj   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Enabling the study of gene function in gymnosperms: Virus‐induced gene silencing in Ephedra tweedieana

Applications in Plant Sciences, EarlyView.
Abstract Premise As the sister clade to angiosperms, extant gymnosperms are crucial for reconstructing ancestral gene regulatory networks in seed plants. This highlights the need for model systems representing each of their distinct lineages. However, tools to quickly and effectively investigate gene function in gymnosperms are still limited due to the
Anthony G. K. Garcia, Jo Trang Bùi, Todd P. Michael, Stefanie M. Ickert‐Bond, Verónica S. Di Stilio   +4 more
wiley   +1 more source

The kinetoplastid-infecting Bodo saltans virus (BsV), a window into the most abundant giant viruses in the sea

eLife, 2018
Giant viruses are ecologically important players in aquatic ecosystems that have challenged concepts of what constitutes a virus. Herein, we present the giant Bodo saltans virus (BsV), the first characterized representative of the most abundant group of ...
Christoph M Deeg, Cheryl-Emiliane T Chow, Curtis A Suttle   +2 more
doaj   +1 more source

Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs

The Anatomical Record, EarlyView.
Abstract Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.
Alexis Cornille, Kyla Beguesse, Ewan Wolff, Clemens Zinner, Patrick Asbach, François Clarac, Florian Witzmann   +6 more
wiley   +1 more source

Genome-resolved year-round dynamics reveal a broad range of giant virus microdiversity

mSystems
Giant viruses are crucial for marine ecosystem dynamics because they regulate microeukaryotic community structure, accelerate carbon and nutrient cycles, and drive the evolution of their hosts through co-evolutionary processes.
Yue Fang, Lingjie Meng, Jun Xia, Yasuhiro Gotoh, Tetsuya Hayashi, Keizo Nagasaki, Hisashi Endo, Yusuke Okazaki, Hiroyuki Ogata   +8 more
doaj   +1 more source