Results 21 to 30 of about 21,469 (223)

Advantages and Limits of Metagenomic Assembly and Binning of a Giant Virus

mSystems, 2020
Giant viruses have large genomes, often within the size range of cellular organisms. This distinguishes them from most other viruses and demands additional effort for the successful recovery of their genomes from environmental sequence data.
Frederik Schulz, Julien Andreani, Rania Francis, Hadjer Boudjemaa, Jacques Yaacoub Bou Khalil, Janey Lee, Bernard La Scola, Tanja Woyke   +7 more
doaj   +3 more sources

Giant Virus Infection Signatures Are Modulated by Euphotic Zone Depth Strata and Iron Regimes of the Subantarctic Southern Ocean

mSystems, 2023
Viruses can alter the abundance, evolution, and metabolism of microorganisms in the ocean, playing a key role in water column biogeochemistry and global carbon cycles. Large efforts to measure the contribution of eukaryotic microorganisms (e.g., protists)
Naomi E. Gilbert, Gary R. LeCleir, Helena L. Pound, Robert F. Strzepek, Michael J. Ellwood, Benjamin S. Twining, Simon Roux, Philip W. Boyd, Steven W. Wilhelm   +8 more
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Giant virus vs amoeba: fight for supremacy

Virology Journal, 2019
Since the discovery of mimivirus, numerous giant viruses associated with free-living amoebae have been described. The genome of giant viruses can be more than 2.5 megabases, and virus particles can exceed the size of many bacteria.
Graziele Oliveira, Bernard La Scola, Jônatas Abrahão   +2 more
doaj   +1 more source

Near-atomic, non-icosahedrally averaged structure of giant virus Paramecium bursaria chlorella virus 1

Nature Communications, 2022
Giant viruses are large DNA viruses with capsid diameters up to 500 nm. Given technical challenges only few high-resolution structures of viral capsids exist. Here, Shao et al.
Qianqian Shao, Irina V. Agarkova, Eric A. Noel, David D. Dunigan, Yunshu Liu, Aohan Wang, Mingcheng Guo, Linlin Xie, Xinyue Zhao, Michael G. Rossmann, James L. Van Etten, Thomas Klose, Qianglin Fang   +12 more
doaj   +1 more source

Exploring nucleo-cytoplasmic large DNA viruses in Tara Oceans microbial metagenomes [PDF]

, 2013
Nucleo-cytoplasmic large DNA viruses (NCLDVs) constitute a group of eukaryotic viruses that can have crucial ecological roles in the sea by accelerating the turnover of their unicellular hosts or by causing diseases in animals. To better characterize the
Moreau, Hervé, Lima-Medez, Gipsi, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Bork, Peer, Subirana, Lucie, Wincker, Patrick, Poulain, Julie, Sarmento, Hugo, Desdevises, Yves, Villar, Emilie, Kandels-Lewis, Stefanie, Acinas, Silvia G., Faust, Karoline, Ogata, Hiroyuki, Grimsley, Nigel, Pesant, Stéphane, Jaillon, Olivier, Claverie, Jean-Michel, Hingamp, Pascal, Not, Fabrice, Karsenti, Eric, Clerissi, Camille, Ferrera, Isabel, de Vargas, Colomban, Sunagawa, Shinichi, Raes, Jeroen   +25 more
core   +1 more source

Multiple evolutionary origins of giant viruses [version 1; referees: 4 approved]

F1000Research, 2018
The nucleocytoplasmic large DNA viruses (NCLDVs) are a monophyletic group of diverse eukaryotic viruses that reproduce primarily in the cytoplasm of the infected cells and include the largest viruses currently known: the giant mimiviruses, pandoraviruses,
Eugene V. Koonin, Natalya Yutin
doaj   +1 more source

From Mimivirus to Mirusvirus: The Quest for Hidden Giants

Viruses, 2023
Our perception of viruses has been drastically evolving since the inception of the field of virology over a century ago. In particular, the discovery of giant viruses from the Nucleocytoviricota phylum marked a pivotal moment.
Morgan Gaïa, Patrick Forterre
doaj   +1 more source

Virus-encoded histone doublets are essential and form nucleosome-like structures [PDF]

, 2021
International audienceThe organization of genomic DNA into defined nucleosomes has long been viewed as a hallmark of eukaryotes. This paradigm has been challenged by the identification of “minimalist” histones in archaea and more recently by the ...
White, Alison, Luger, Karolin, Philippe, Nadege, Bisio, Hugo, Edwards, Garrett, Abergel, Chantal, Zhou, Keda, Liu, Yang, Bowerman, Samuel, Toner, Chelsea, Marie, Toner, Chelsea,, Jeudy, Sandra, Toner, Chelsea Marie   +12 more
core   +1 more source

Virome comparisons in wild-diseased and healthy captive giant pandas

Microbiome, 2017
Background The giant panda (Ailuropoda melanoleuca) is a vulnerable mammal herbivore living wild in central China. Viral infections have become a potential threat to the health of these endangered animals, but limited information related to these ...
Wen Zhang, Shixing Yang, Tongling Shan, Rong Hou, Zhijian Liu, Wang Li, Lianghua Guo, Yan Wang, Peng Chen, Xiaochun Wang, Feifei Feng, Hua Wang, Chao Chen, Quan Shen, Chenglin Zhou, Xiuguo Hua, Li Cui, Xutao Deng, Zhihe Zhang, Dunwu Qi, Eric Delwart   +20 more
doaj   +1 more source