Results 151 to 160 of about 630,138 (258)

Efficacy and safety of fruquintinib combined with albumin‐bound paclitaxel as second‐line therapy for advanced gastric cancer following failure of PD‐1 inhibitor‐containing treatment (TACTIC GC‐01): A phase II single‐arm study

open access: yesInternational Journal of Cancer, Volume 158, Issue 9, Page 2219-2228, 1 May 2026.
What's new? Anti‐angiogenic drugs have shown promising efficacy as a second‐line treatment for advanced gastric cancer. However, it remains unclear how alterations in the tumor microenvironment following first‐line immunotherapy may impact tumor angiogenesis and influence subsequent therapeutic outcomes. This single‐arm study prospectively explored the
Xiaoting Ma   +11 more
wiley   +1 more source

2026 Update on the Management of Diffuse Large B‐Cell Lymphoma

open access: yesAmerican Journal of Hematology, Volume 101, Issue 4, Page 832-863, April 2026.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common type of NHL in the Western Hemisphere. It comprises a heterogenous group of lymphomas, with different biology and clinical prognoses. R‐CHP remains the backbone of therapy, and frontline therapeutic options in fit patients are pola‐R‐CHP and R‐CHOP, whereas elderly or frail/unfit ...
Elise A. Chong   +2 more
wiley   +1 more source

Examining aspects of job satisfaction associated with burnout and factors related to turnover intention in genetic counselors

open access: yesJournal of Genetic Counseling, Volume 35, Issue 2, April 2026.
Abstract Burnout arises from prolonged work‐related stress, leading to a chronic state of exhaustion, cynicism, and diminished professional efficacy. Previous studies have shown that ~50% of genetic counselors (GCs) experience burnout. This has negative implications for the GCs themselves, their employers, and patient care. Research in other healthcare
Kaitlin J. Stanley   +4 more
wiley   +1 more source

Cistanche tubulosa Extract Protects Cast Immobilization‐Induced Declines of Muscle Strength and Muscle Mass

open access: yesTraditional &Kampo Medicine, Volume 13, Issue 1, April 2026.
ABSTRACT Aim One of the effects of Cistanche herb is described in the Chinese Pharmacopoeia as for lack of strength in muscles and bones. However, concrete evidence of this herb for muscle strength has been hardly reported. The present study aimed to clarify the effects of 30% ethanolic extract of Cistanche tubulosa fleshy stem on muscle strength and ...
Jae‐Won Jung, Chihiro Tohda
wiley   +1 more source

A Foundation for Advancing Studies of the Biodegradation of Polyethylene Surrogates by Environmental and Model Laboratory Microbes

open access: yesEnvironmental Microbiology Reports, Volume 18, Issue 2, April 2026.
A polyethylene surrogate sample containing paraffin, polywax and polyethylene was exposed to selected microbes identified in this study. This image shows the surface of this surrogate following a six‐week incubation with Rhodococcus jostii. ABSTRACT Polyethylene represents a particularly recalcitrant class of plastics that persist for decades in the ...
Bilge Bahar Camur   +5 more
wiley   +1 more source

Comparative Effectiveness and Safety of PI‐Rd Triplets in Relapsed/Refractory Multiple Myeloma: INSIGHT‐MM Data Analysis

open access: yesEuropean Journal of Haematology, Volume 116, Issue 4, Page 458-470, April 2026.
Assessment of the comparative effectiveness and safety of three PI‐Rd triplets in relapsed/refractory multiple myeloma using data from the global, non‐interventional, observational INSIGHT‐MM study. ABSTRACT Objectives To assess the effectiveness/safety of three proteasome inhibitors (PIs), plus lenalidomide‐dexamethasone (Rd) triplet regimens, for the
Noemi Puig   +18 more
wiley   +1 more source

Real‐Time Anxiety and Depression Detection by Combining Large Language Models and Machine Learning With Explainability Capabilities on a User‐Centric, Engaging Conversational Assistant

open access: yesExpert Systems, Volume 43, Issue 4, April 2026.
ABSTRACT Mental well‐being is a worldwide priority of health systems. Nevertheless, the diagnosis and recovery rates are still low. This work demonstrates an Artificial Intelligence (AI)‐based, entertainment‐oriented, engaging assistant that can deliver on‐demand, non‐judgmental assessment in an accessible, scalable, and personalised way to people ...
Silvia García‐Méndez   +3 more
wiley   +1 more source

Effects of Cannabidiol on TAFAZZIN‐Deficient B‐Lymphoblastoid Cells

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Deficiency of the cardiolipin remodeling enzyme TAFAZZIN causes Barth syndrome (BTHS), resulting in cardiolipin loss, monolysocardiolipin (MLCL) accumulation, and electron transport chain (ETC) abnormalities in B‐lymphoblastoid cells. Effects of the non‐psychotropic phytocannabinoid cannabidiol (CBD) were examined on B‐lymphoblastoid cells from ...
John Z. Chan   +10 more
wiley   +1 more source

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