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Overview of Gilbert’s syndrome

Drug and Therapeutics Bulletin, 2019
### Key learning points Gilbert’s syndrome (GS) is a benign hereditary disorder of bilirubin conjugation resulting in an isolated, elevated blood level of unconjugated bilirubin.1 GS affects 2%–10% of the Caucasian population in the Western world.2,3 The inheritance pattern for GS is commonly autosomal recessive, but can be dominant as well; however ...
D, King, M J, Armstrong
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Gilbert Syndrome

International Journal of Nursing Education and Research, 2021
Gilbert's syndrome (GS) is a benign condition that does not progress to chronic liver disease or fibrosis. GS diagnosis should be considered in patients with chronic elevation of unconjugated bilirubin. In these patients the presence of hemolysis and other diseases of the liver should be excluded.
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Gilbert Syndrome

Gastroenterology Nursing, 1996
Two or three times a year, a healthy patient (> 1 year old) with mild unconjugated hyperbilirubinemia as the only abnormality on routine liver function testing will be referred to the gastroenterologist. A diagnosis of Gilbert Syndrome (GS) is made, and the patient may or may not be seen in the clinic or office because GS is a benign condition.
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Pathogenesis of Gilbert's syndrome

European Journal of Clinical Investigation, 1981
Chronic unconjugated hyperbilirubinaemia is a frequent finding. Overt haemolysis, dyserythropoiesis and other diseases including hepatobiliary, cardiac and thyroid disorders [1] have to be ruled out. The diagnosis of Gilbert's syndrome is then usually put forward if the history and clinical and laboratory investigations are normal. This benign disorder
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Gilbert syndrome.

European journal of pediatrics, 2012
Gilbert syndrome is a common autosomal dominant hereditary condition with incomplete penetrance and characterized by intermittent unconjugated hyperbilirubinemia in the absence of hepatocellular disease or hemolysis. In patients with Gilbert syndrome, uridine diphosphate-glucuronyl transferase activity is reduced to 30% of the normal, resulting in ...
Andrew, Fretzayas   +3 more
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Gilbert's Syndrome—Does It Exist?

Acta Medica Scandinavica, 1988
Abstract. Liver function tests and prevalence of different symptoms generally said to occur in Gilbert's syndrome were analysed in male conscripts and in male and female participants in two cross‐sectional population studies in Göteborg, in total 2395 subjects. The serum bilirubin levels showed a skew distribution without bimodality.
R, Olsson   +6 more
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UDP-Glucuronosyltransferase in gilbert’s syndrome

Pathology, 1996
The diagnosis of Gilbert's syndrome, a condition characterised by mild jaundice related to chronic unconjugated hyperbilirubinemia, is often presumptive and the pathogenesis is incompletely understood. It would be of interest to develop an immunohistochemical staining method to confirm a diagnosis of Gilbert's syndrome.
H S, Debinski   +5 more
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Evaluation of Tests for Gilbert's Syndrome

Acta Medica Scandinavica, 1980
ABSTRACT. The effect of caloric restriction (400 kcal for 24 hours) on serum total and unconjugated bilirubin was studied in 30 subjects with Gilbert's syndrome and in 22 patients with different liver diseases. The method could not completely differentiate between Gilbert's syndrome and liver disease, but an increase in unconjugated bilirubin of 15 ...
R, Olsson, G, Lindstedt
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TREATMENT OF GILBERT'S SYNDROME WITH PHENOBARBITONE

The Lancet, 1970
Abstract Thirteen patients with Gilbert's syndrome have been treated with phenobarbitone. In all instances there was a rapid fall in the plasma-bilirubin, and in three of the ten symptomatic patients the symptoms improved. The reduction in the plasma-bilirubin was associated with, and thought to be the result of, an increase in hepatic bilirubin U.D.P.
M, Black, S, Sherlock
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