Results 201 to 210 of about 13,120 (243)
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Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography–mass spectrometry: Application to pharmacokinetics

Journal of Chromatography B, 2009
A rapid high-performance liquid chromatography-mass spectrometry (HPLC-MS) method was developed and validated for simultaneous quantification of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma after oral administration of ginger oleoresin.
Wei, Wang   +4 more
openaire   +2 more sources

Effects of standardized [6]-gingerol extracts and [6]-gingerol on isolated ileum and lower esophageal sphincter contractions in mice

Food Chemistry, 2022
Standardized [6]-gingerol extracts were prepared by microwave-assisted extraction using 20% v/v glycerin in ethanol and 20% v/v eutectic mixture of sucrose and citric acid in ethanol as alternative green solvents. The extracts obtained from 20% v/v glycerin in ethanol (GEE) and 20% v/v eutectic mixture of sucrose and citric acid in ethanol (EMSCEE ...
Nantaporn, Promdam   +2 more
openaire   +2 more sources

Perspectives on two major bioactives in ginger, 6-gingerol and 6-shogaol, focusing on the in vivo metabolic fate and bioactivities

Critical reviews in food science and nutrition
Ginger, a globally cultivated spice and medicinal herb, is renowned for its health benefits and distinctive flavor. As ginger’s main pungent and bioactive components, 6-gingerol and 6-shogaol share similar physicochemical properties and can be obtained ...
Yu Zhou   +9 more
semanticscholar   +1 more source

The Stability of Gingerol and Shogaol in Aqueous Solutions

Journal of Pharmaceutical Sciences, 2001
Gingerols, pungent principles of ginger (the rhizome of Zingiber officinale), are biologically active components that may make a significant contribution towards medicinal applications of ginger and some products derived from ginger. Gingerols, however, are thermally labile due to the presence of a beta-hydroxy keto group in the structure, and undergo ...
S, Bhattarai, V H, Tran, C C, Duke
openaire   +2 more sources

6-Gingerol overcomes TMZ resistance in GBM by suppressing EMT and cell migration via the PI3K/Akt/β-catenin/c-Myc pathway.

International Immunopharmacology
Glioblastoma multiforme (GBM) is the most aggressive and treatment-resistant primary brain tumor with acquired resistance to temozolomide (TMZ) posing a major clinical challenge.
Yao-lin Lee   +8 more
semanticscholar   +1 more source

6-Gingerol ameliorates ulcerative colitis by inhibiting ferroptosis based on the integrative analysis of plasma metabolomics and network pharmacology.

Food & Function
6-Gingerol (6-G), an active ingredient of ginger with anti-inflammation and anti-oxidation properties, can treat ulcerative colitis (UC). However, its underlying mechanism is still unclear.
Wen-wen Li   +7 more
semanticscholar   +1 more source

Synthesis of the [8] gingerol enantiomers

Chirality, 1991
Abstract(+)‐(S)‐5‐Hydroxy‐1‐(4‐hydroxy‐3‐methoxyphenyl)‐3‐dodecanone 1a commonly named (+)‐(S)‐[8] gingerol is a natural product known to have cardiotonic activity.1–5 A total synthesis of both enantiomers is described with details for the first time using a general synthetic scheme which was recently outlined in the literature.6 This synthesis relies ...
Michel Martin, Philippe Guibet
openaire   +1 more source

Encapsulation of gingerol into nanoliposomes: Evaluation of in vitro anti-inflammatory and anti-cancer activity.

Biomedical chromotography
Nanoliposomes (NLs) are ideal carriers for delivering complex molecules and phytochemical products, but ginger by-products, despite their therapeutic benefits, have poor bioavailability due to their low water solubility and stability.
Fatimah A. Alshaikh   +9 more
semanticscholar   +1 more source

Intervention effects of delivery vehicles on the therapeutic efficacy of 6-gingerol on colitis.

Journal of Controlled Release, 2022
The emerging concept that "the maximized therapeutic efficacy of encapsulates would be achieved by inducing appropriate absorption site and pharmacological signal pathways through smart intervention of targeted delivery systems" is quite intriguing in ...
Wenni Tian   +6 more
semanticscholar   +1 more source

The active part of the [6]-gingerol molecule in mutagenesis

Mutation Research Letters, 1983
A study was performed to discover the active part in mutagenesis of [6]-gingerol, a mutagen contained in ginger Zingiber officinale (Nakamura and Yamamoto, 1982). [6]-Shogaol was isolated from the ginger by column chromatography on silica gel. [6]-Shogaol was much less mutagenic (1 X 10(3) revertants/10(8) viable cells/700 microM) than [6]-gingerol (1 ...
H, Nakamura, T, Yamamoto
openaire   +2 more sources

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