Results 61 to 70 of about 13,120 (243)

Unraveling the interconversion pharmacokinetics and oral bioavailability of the major ginger constituents: [6]-gingerol, [6]-shogaol, and zingerone after single-dose administration in rats

Frontiers in Pharmacology
Background The available in vitro evidences suggest the inherent instability and interconvertibility of [6]-gingerol and [6]-shogaol. However, limited data on their in vivo interconversion hinder understanding of their influence on the pharmacokinetic ...
Phanit Songvut, Watanyoo Nakareangrit, W. Cholpraipimolrat, Jackapun Kwangjai, Luksamee Worasuttayangkurn, Piyajit Watcharasit, J. Satayavivad   +6 more
semanticscholar   +1 more source

Extracellular vesicles derived from edible plants and edible fungi: Compositional characteristics, engineering strategies and biofunctions

Food Biomacromolecules, EarlyView.
Non‐animal extracellular vesicles as bioactive‐compound carriers: compositional characteristics, engineering strategies, and biofunctions. Abstract Animal‐derived extracellular vesicles (EVs) were widely used for bioactive compound delivery but constrained by complex origins, potential immunogenicity, and pathogen contamination.
Jiahao Yu, Rongheng Chen, Yuxuan Liu, Yizhen Xie, Fangyu Fan, Simin Feng, Ping Shao   +6 more
wiley   +1 more source

10-Gingerol Targets Lipid Rafts Associated PI3K/Akt Signaling in Radio-Resistant Triple Negative Breast Cancer Cells

Molecules, 2020
10-Gingerol is a major phenolic lipid found in the rhizomes of ginger (Zingiber officinale). Being amphiphilic in nature, phenolic lipids have the ability to incorporate into cell membranes and modulate membrane properties.
Meran Keshawa Ediriweera, Jeong Yong Moon, Yen Thi-Kim Nguyen, Somi Kim Cho   +3 more
doaj   +1 more source

Renoprotective effect of a novel combination of 6-gingerol and metformin in high-fat diet/streptozotocin-induced diabetic nephropathy in rats via targeting miRNA-146a, miRNA-223, TLR4/TRAF6/NLRP3 inflammasome pathway and HIF-1α

Biological Research
Background MiRNA-146a and miRNA-223 are key epigenetic regulators of toll-like receptor 4 (TLR4)/tumor necrosis factor-receptor-associated factor 6 (TRAF6)/NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome pathway, which is involved
Merna G. Aboismaiel, M. N. Amin, L. Eissa   +2 more
semanticscholar   +1 more source

Functional diabetic biscuits enriched with cereal fibers, black plum (jamun) and bioactive spices

Food Biomacromolecules, EarlyView.
Cereal fibres, black plum (jamun) seed powder and bioactive spices can be combined with controlled mixing, hydration and baking to design functional biscuits. Fibre‐rich structures may limit starch accessibility, while polyphenols may inhibit starch‐digesting enzymes.
Renukadevi Jeyavelkumaran, Saranya Krishnan, Mridula Dhanapal Saravanan, Nimithasree Keerthivasan   +3 more
wiley   +1 more source

6-Gingerol improves lipid metabolism disorders in skeletal muscle by regulating AdipoR1/AMPK signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
BACKGROUND To delve into the precise mechanisms by which 6-gingerol ameliorates lipid metabolism disorders in skeletal muscle. METHODS The level of triglycerides (TG) was used to evaluate lipid deposition.
Ze Peng, Yan Zeng, Xin Zeng, Qi Tan, Qi-Feng He, Shang Wang, Jian-Wei Wang   +6 more
semanticscholar   +1 more source

6-Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine-Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity

Mediators of Inflammation, 2021
Diethylnitrosamine (DEN) is a well‐known hepatocarcinogen, and its oral administration causes severe liver damage including cancer. DEN induces the pathogenesis of the liver through reactive oxygen species mediated inflammation and modulation of various ...
M. Alsahli, S. Almatroodi, A. Almatroudi, A. Khan, S. Anwar, Abdulmajeed G. Almutary, Faris A Alrumaihi, A. Rahmani   +7 more
semanticscholar   +1 more source

Review of phytochemical and antioxidant properties of Ethiopian medicinal plants

JSFA reports, EarlyView.
Abstract Ethiopia possesses a rich ethnobotanical heritage and diverse medicinal flora that play an important role in traditional healthcare. Many Ethiopian medicinal plants contain bioactive phytochemicals with potential antioxidant properties. This capital of indigenous knowledge has contributed to the documentation of different medicinal plants that
Endalamaw Yihune, Amare Bitew Mekonnen, Getahun Yemata   +2 more
wiley   +1 more source

Study on the Interaction of Gingerol and Sudan Dye

, 2011
The antioxidation activity and the linear relationship between the absorbance and the concentration of gingerol were detected in different condition. Gingerol’s median effect concentration(EC50) was 7.6165ug·mL-1and its TAC was higher than that of ginger
Long Jun Xu, Tai Ping Xie, Zheng Shi Liu, Cheng Lun Liu, Chun Lan He   +4 more
core   +1 more source

Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications

Metabolites, 2022
Hyperglycemia is seen in approximately 68 percent of patients admitted to a medical intensive care unit (ICU). In many acute circumstances, such as myocardial infarction, brain, injury and stroke, it is an independent predictor of mortality ...
K. S. Alharbi, M. Nadeem, O. Afzal, Sami I. Alzarea, A. S. Altamimi, W. Almalki, Bismillah Mubeen, S. Iftikhar, Luqman Shah, I. Kazmi   +9 more
semanticscholar   +1 more source