Results 41 to 50 of about 13,120 (243)

Ameliorative effects of 6‑gingerol in cerebral ischemia are mediated via the activation of antioxidant and anti‑inflammatory pathways

Biomedical Reports, 2023
Focal ischemia occurs when an embolus or thrombus occludes an artery, causing the rapid obstruction of cerebral blood flow. Although stroke represents a main cause of disability and mortality in developing countries, therapeutic approaches available for ...
R. Kongsui, J. Jittiwat
semanticscholar   +1 more source

6-Gingerol Ameliorates Adiposity and Inflammation in Adipose Tissue in High Fat Diet-Induced Obese Mice: Association with Regulating of Adipokines

Nutrients, 2023
We investigated the effects of 6-gingerol on adiposity and obesity-induced inflammation by focusing on the regulation of adipogenesis and adipokines in white adipose tissue (WAT) of diet-induced obese mice.
K. Hong, M. Um, Jiyun Ahn, T. Ha
semanticscholar   +1 more source

GINGEROL AND PARADOL.¹ [PDF]

Journal of the American Chemical Society, 1917
n ...
openaire   +1 more source

Kinetic Study and Optimization of the Most Influential Factor on Batch-Extraction of Gingerol from Fresh Ginger (Zingiber officinale) Rhizomes by Using n-Hexane as a Solvent

Reaktor, 2018
A solvent extraction of 6- gingerol from fresh ginger rhizome chips using n-hexane has been successfully carried out. This study aimed to investigate the effects of temperature, feed size, and feed mass on the yield of gingerol, to observe the kinetics ...
Margaretha Praba Aulia, Fitra Pradhita, Andri Cahyo Kumoro, Marcelinus Christwardana, H. Hargono   +4 more
doaj   +1 more source

Gingerol supplementation does not change glucose tolerance, lipid profile and does not prevent weight gain in C57BL/6 mice fed a high-fat diet

Clinical Nutrition Experimental, 2020
Summary: We hypothesized that gingerol supplementation would exert protective effects against high-fat diet (HFD)-induced weight gain via regulation of lipid and glucose homeostasis. To test our hypothesis, forty C57BL/6 mice were fed a standard diet (SD)
Aline Jose Coelho Moreira Zordan, Caroline Bertoncini-Silva, Anderson Gregorio Joaquim, Marina Rodrigues, Cássia Dias Machado, Daniela Carlos, Maria Cristina Foss-Freitas, Vivian Marques Miguel Suen   +7 more
doaj   +1 more source

Preparation and Evaluation of 6-Gingerol Derivatives as Novel Antioxidants and Antiplatelet Agents

Antioxidants, 2023
Ginger (Zingiber officinale) is widely used as a spice and a traditional medicine. Many bioactivities have been reported for its extracts and the isolated compounds, including cardiovascular protective effects.
S. Ahmed, T. Gonda, O. Agbadua, G. Girst, R. Berkecz, N. Kúsz, M. Tsai, Chin-Chung Wu, G. Balogh, A. Hunyadi   +9 more
semanticscholar   +1 more source

Intestinal 8 gingerol attenuates TBI-induced neuroinflammation by inhibiting microglia NLRP3 inflammasome activation in a PINK1/Parkin-dependent manner.

Phytomedicine
BACKGROUND traumatic brain injury (TBI) is irreversible brain damage, leading to inflammation and cognitive dysfunction. Microglia involved in the inflammatory response after TBI.
Xuheng Tang, Lin Huang, Weiquan Ma, Ming-Liang Huang, Zhenhua Zeng, Yiqin Yu, N. Qin, F. Zhou, Fen Li, Shenhai Gong, Hong Yang   +10 more
semanticscholar   +1 more source

Computer aided gene mining for gingerol biosynthesis [PDF]

Bioinformation, 2015
Inspite of the large body of genomic data obtained from the transcriptome of Zingiber officinale, very few studies have focused on the identification and characterization of miRNAs in gingerol biosynthesis. Zingiber officinale transcriptome was analyzed using EST dataset (38169 total) deposited in public domains.
James, Priyanka, Baby, Bincy, Charles, SonaSona, Nair, Lekshmysree Saraschandran, Nazeem, Puthiyaveetil Abdulla   +4 more
openaire   +2 more sources

Assessing the antibacterial potential of 6-gingerol: Combined experimental and computational approaches

Saudi Pharmaceutical Journal
The rise of antibiotic resistance in bacteria is becoming a global concern, particularly due to the dwindling supply of new antibiotics. This situation mandates the discovery of new antimicrobial candidates.
M. A. Elfaky, Hassan M. Okairy, H. M. Abdallah, Abdulrahman E. Koshak, G. A. Mohamed, S. Ibrahim, A. A. Alzain, Wael A. H. Hegazy, El-Sayed Khafagy, Noura M. Seleem   +9 more
semanticscholar   +1 more source

[6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice

BMC Complementary and Alternative Medicine, 2017
Background [6]-Gingerol, a major component of Zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. Endocrine signaling is involved in insulin secretion and is perturbed in db/db Type-2 diabetic mice.
Mehdi Bin Samad, Md. Nurul Absar Bin Mohsin, Bodiul Alam Razu, Mohammad Tashnim Hossain, Sinayat Mahzabeen, Naziat Unnoor, Ishrat Aklima Muna, Farjana Akhter, Ashraf Ul Kabir, J. M. A. Hannan   +9 more
doaj   +1 more source