Porphyromonas gingivalis and Treponema denticola are periodontal pathogens that express virulence factors associated with the pathogenesis of periodontitis. In this paper we tested the hypothesis that P. gingivalis and T. denticola are synergistic in terms of virulence; using a model of mixed microbial infection in rats.
Raj K. Verma +10 more
wiley +1 more source
Enteric bacterial proteases in inflammatory bowel disease- pathophysiology and clinical implications [PDF]
Numerous reports have identified a dysbiosis in the intestinal microbiota in patients suffering from inflammatory bowel diseases (IBD), yet the mechanism(s) in which this complex microbial community initiates or perpetuates inflammation remains unclear ...
Carroll, Ian M., Maharshak, Nitsan
core +2 more sources
Oral SARS‐CoV‐2 Infection and Risk for Long Covid
ABSTRACT SARS‐CoV‐2 is an oral pathogen that infects and replicates in mucosal and salivary epithelial cells, contributing to oral post‐acute sequelae COVID‐19 (PASC) and other oral and non‐oral pathologies. While pre‐existing inflammatory oral diseases provides a conducive environment for the virus, acute infection and persistence of SARS‐CoV‐2 can ...
Joel Schwartz +5 more
wiley +1 more source
Identification of a new subtype of dipeptidyl peptidase 11 and a third group of the S46-family members specifically present in the genus Bacteroides [PDF]
Peptidase family S46 consists of two types of dipeptidyl-peptidases (DPPs), DPP7 and DPP11, which liberate dipeptides from the N-termini of polypeptides along with the penultimate hydrophobic and acidic residues, respectively.
Bezerra Gustavo Arruda +5 more
core +2 more sources
HPV-related and unrelated oropharyngeal cancer : Contribution of oral pathobionts Treponema denticola and Porphyromonas gingivalis to carcinogenesis [PDF]
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) associated with human papillomavirus (HPV) has increased in western countries in the last decades, whereas the number of HPV unrelated OPSCC cases has remained stable or even declined.
Kylmä, Anna Kaisa
core
Non‐canonical amino acid bioincorporation into antimicrobial peptides and its challenges
Bioincorporation of non‐canonical amino acids (ncAAs) as a method of integration into antimicrobial peptides (AMPs) is an emerging field geared towards developing solid‐phase synthesis as a green, cheaper, and scalable alternative for commercialisation of AMPs.
George Nkrumah Enninful +4 more
wiley +1 more source
Ecological, beneficial, and pathogenic functions of the Type 9 Secretion System
This mini review delves into the broad spectrum of proteins secreted by the bacterial type 9 secretion system (T9SS). It focuses on the roles of T9SS‐secreted proteins in pathogenesis, bacterial interactions, host colonization, and the maintenance of ecosystem health.
Sofia T. Rocha +2 more
wiley +1 more source
Abstract COVID‐19 as a pan‐epidemic is waning but there it is imperative to understand virus interaction with oral tissues and oral inflammatory diseases. We review periodontal disease (PD), a common inflammatory oral disease, as a driver of COVID‐19 and oral post‐acute‐sequelae conditions (PASC). Oral PASC identifies with PD, loss of teeth, dysgeusia,
Joel Schwartz +4 more
wiley +1 more source
Development of low-cost and portable detection platforms for bacterial detection [PDF]
In this study, a diagnostic platform for detecting pathogens, including Listeria monocytogenes, E. coli O157:H11, Staphylococcus aureus, Legionella spp., P. gingivalis, and Pseudomonas aeruginosa, has been developed. Fluorogenic substrates were used as a
Alhogail, Sahar
core
Modes of inhibition of cysteine proteases [PDF]
Cysteine proteases are involved in many physiological processes and their hyperactivity may lead to severe diseases. Nature has developed various strategies to protect cells and whole organisms against undesired proteolysis. One of them is the control of
Chmiel, Dorota +2 more
core

