Results 11 to 20 of about 430 (84)
Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
Interdisciplinary Perspectives on Infectious Diseases, Volume 2010, Issue 1, 2010., 2010 Porphyromonas gingivalis and Treponema denticola are periodontal pathogens that express virulence factors associated with the pathogenesis of periodontitis. In this paper we tested the hypothesis that P. gingivalis and T. denticola are synergistic in terms of virulence; using a model of mixed microbial infection in rats.
Raj K. Verma +10 more
wiley +1 more source
Journal of Periodontal Research, Volume 61, Issue 4, Page 355-371, April 2026.This graphical abstract illustrates the role of matrix metalloproteinases (MMPs) across the pathogenesis, diagnosis, and therapeutics of periodontal and peri‐implant diseases. Microbial and host stimuli trigger MMP activation leading to extracellular matrix breakdown, point‐of‐care aMMP‐8 detection aids diagnosis, and adjunctive or AI‐assisted ...
Timo Sorsa +5 more
wiley +1 more source
Oral SARS‐CoV‐2 Infection and Risk for Long Covid
Reviews in Medical Virology, Volume 35, Issue 2, March 2025.ABSTRACT SARS‐CoV‐2 is an oral pathogen that infects and replicates in mucosal and salivary epithelial cells, contributing to oral post‐acute sequelae COVID‐19 (PASC) and other oral and non‐oral pathologies. While pre‐existing inflammatory oral diseases provides a conducive environment for the virus, acute infection and persistence of SARS‐CoV‐2 can ...
Joel Schwartz +5 more
wiley +1 more source
Non‐canonical amino acid bioincorporation into antimicrobial peptides and its challenges
Journal of Peptide Science, Volume 30, Issue 6, June 2024.Bioincorporation of non‐canonical amino acids (ncAAs) as a method of integration into antimicrobial peptides (AMPs) is an emerging field geared towards developing solid‐phase synthesis as a green, cheaper, and scalable alternative for commercialisation of AMPs.
George Nkrumah Enninful +4 more
wiley +1 more source
Ecological, beneficial, and pathogenic functions of the Type 9 Secretion System
Microbial Biotechnology, Volume 17, Issue 6, June 2024.This mini review delves into the broad spectrum of proteins secreted by the bacterial type 9 secretion system (T9SS). It focuses on the roles of T9SS‐secreted proteins in pathogenesis, bacterial interactions, host colonization, and the maintenance of ecosystem health.
Sofia T. Rocha +2 more
wiley +1 more source
Reviews in Medical Virology, Volume 34, Issue 3, May 2024.Abstract COVID‐19 as a pan‐epidemic is waning but there it is imperative to understand virus interaction with oral tissues and oral inflammatory diseases. We review periodontal disease (PD), a common inflammatory oral disease, as a driver of COVID‐19 and oral post‐acute‐sequelae conditions (PASC). Oral PASC identifies with PD, loss of teeth, dysgeusia,
Joel Schwartz +4 more
wiley +1 more source
Isolation, characterization, and fibroblast uptake of bacterial extracellular vesicles from Porphyromonas gingivalis strains. [PDF]
Microbiologyopen, 2023 Haugsten HR +7 more
europepmc +1 more source
Production and properties of adhesin-free gingipain proteinase RgpA. [PDF]
Sci Rep, 2023 Mahmud ASM +7 more
europepmc +1 more source
Heterogeneous Systemic IgG Responses to Porphyromonas gingivalis Gingipains in Advanced Periodontitis. [PDF]
Clin Exp Dent ResBüttner S +6 more
europepmc +1 more source