Results 1 to 10 of about 428 (84)

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease. [PDF]

J Intern Med
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Barron AE, Lin JS, Ryder MI, Bergman P.
europepmc   +2 more sources

Insights Into the Mechanism of Action of Chlorhexidine on <i>Porphyromonas gingivalis</i>. [PDF]

Int J Dent
Chlorhexidine (CHX) remains the most effective antiseptic in periodontal therapy, multiple reports have identified ultrastructural antibacterial effects of CHX on oral bacteria, however, little is known about its molecular mechanism of action on Porphyromonas gingivalis, an important pathobiont directly associated with the pathogenesis of periodontitis.
Mejía K, Rodríguez-Hernández AP, Martínez-Hernández M.   +2 more
europepmc   +2 more sources

Intracellular Porphyromonas gingivalis Promotes the Proliferation of Colorectal Cancer Cells via the MAPK/ERK Signaling Pathway

Frontiers in Cellular and Infection Microbiology, 2020
Porphyromonas gingivalis (P. gingivalis) is a keystone pathogen in periodontitis. However, several clinical studies have revealed an enrichment of P. gingivalis in the stool samples and colorectal mucosa of colorectal cancer patients.
Wenxin Mu, Yiqun Jia, Xiaobing Chen, Haoyu Li, Zhi Wang, Bin Cheng   +5 more
doaj   +1 more source

Contribution of proteases to the hallmarks of aging and to age‐related neurodegeneration

Aging Cell, Volume 21, Issue 5, May 2022., 2022
Proteases are a large family of proteolytic enzymes located in all cell compartments and in the extracellular space. Proteases impact all hallmarks of cellular and tissue aging, and the onset and progression of age‐related diseases including neurodegeneration.
Mamta Rai, Michelle Curley, Zane Coleman, Fabio Demontis   +3 more
wiley   +1 more source

A diverse uncultivated microbial community is responsible for organic matter degradation in the Black Sea sulphidic zone

Environmental Microbiology, Volume 23, Issue 6, Page 2709-2728, June 2021., 2021
Summary Organic matter degradation in marine environments is essential for the recycling of nutrients, especially under conditions of anoxia where organic matter tends to accumulate. However, little is known about the diversity of the microbial communities responsible for the mineralization of organic matter in the absence of oxygen, as well as the ...
Saara Suominen, Nina Dombrowski, Jaap S. Sinninghe Damsté, Laura Villanueva   +3 more
wiley   +1 more source

Dipeptidyl‐peptidases: Key enzymes producing entry forms of extracellular proteins in asaccharolytic periodontopathic bacterium Porphyromonas gingivalis

Molecular Oral Microbiology, Volume 36, Issue 2, Page 145-156, April 2021., 2021
Abstract Porphyromonas gingivalis, a pathogen of chronic periodontitis, is an asaccharolytic microorganism that solely utilizes nutritional amino acids as its energy source and cellular constituents. The bacterium is considered to incorporate proteinaceous nutrients mainly as dipeptides, thus exopeptidases that produce dipeptides from polypeptides are ...
Takayuki K. Nemoto, Yuko Ohara Nemoto
wiley   +1 more source

Bradykinin – An elusive peptide in measuring and understanding

, 2022
Research and Practice in Thrombosis and Haemostasis, Volume 6, Issue 2, February 2022.
Alessandro S. Pinheiro, Sadiq Silbak, Alvin H. Schmaier   +2 more
wiley   +1 more source

Matrix Metalloproteinase‐8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri‐Implant Diseases

International Journal of Dentistry, Volume 2018, Issue 1, 2018., 2018
Levels of and especially the degree of activation of matrix metalloproteinase (MMP‐8) in oral fluids (i.e., saliva, mouth rinse, gingival crevicular fluid (GCF) and peri‐implantitis sulcular fluid (PISF)) increase to pathologically elevated levels in the periodontal and peri‐implant diseases.
Ahmed Al-Majid, Saeed Alassiri, Nilminie Rathnayake, Taina Tervahartiala, Dirk-Rolf Gieselmann, Timo Sorsa, Saso Ivanovski   +6 more
wiley   +1 more source

The Role of Proteinase‐Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease

Journal of Immunology Research, Volume 2017, Issue 1, 2017., 2017
Proteinase‐activated receptors 1 (PAR1) and 2 (PAR2) are the most highly expressed members of the PAR family in the periodontium. These receptors regulate periodontal inflammatory and repair processes through their activation by endogenous and bacterial enzymes.
E. S. Rovai, M. Holzhausen, Kristen M. Kahle   +2 more
wiley   +1 more source

Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2

The FEBS Journal, Volume 280, Issue 11, Page 2608-2621, June 2013., 2013
Metacaspases play an important role in the life cycle of trypanosomes and their absence in humans makes them attractive drug targets. Here we use detailed kinetic, biochemical and structural analyses to investigate the substrate specificity and effects of Ca2+ on the activation of metacaspase 2 from Trypanosoma brucei.
Maurício F. M. Machado, Marcelo F. Marcondes, Maria A. Juliano, Karen McLuskey, Jeremy C. Mottram, Catherine X. Moss, Luiz Juliano, Vitor Oliveira   +7 more
wiley   +1 more source