Results 1 to 10 of about 116 (84)

Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2 [PDF]

The FEBS Journal, Volume 280, Issue 11, Page 2608-2621, June 2013., 2013
Metacaspases are cysteine peptidases found only in yeast, plants and lower eukaryotes, including the protozoa. To investigate the extended substrate specificity and effects of Ca²⁺ on the activation of these enzymes, detailed ...
Juliano, L., Juliano, M.A., Machado, M.K.M, Marcondes, M.F., McLuskey, K., Moss, C.X., Mottram, J.C., Oliveira, V.   +7 more
core   +2 more sources

The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease [PDF]

Journal of Immunology Research, Volume 2017, Issue 1, 2017., 2017
Proteinase-activated receptors 1 (PAR1) and 2 (PAR2) are the most highly expressed members of the PAR family in the periodontium. These receptors regulate periodontal inflammatory and repair processes through their activation by endogenous and bacterial ...
E. S. Rovai, M. Holzhausen
core   +3 more sources

Intracellular Porphyromonas gingivalis Promotes the Proliferation of Colorectal Cancer Cells via the MAPK/ERK Signaling Pathway

Frontiers in Cellular and Infection Microbiology, 2020
Porphyromonas gingivalis (P. gingivalis) is a keystone pathogen in periodontitis. However, several clinical studies have revealed an enrichment of P. gingivalis in the stool samples and colorectal mucosa of colorectal cancer patients.
Wenxin Mu, Yiqun Jia, Xiaobing Chen, Haoyu Li, Zhi Wang, Bin Cheng   +5 more
doaj   +1 more source

Contribution of proteases to the hallmarks of aging and to age‐related neurodegeneration

Aging Cell, Volume 21, Issue 5, May 2022., 2022
Proteases are a large family of proteolytic enzymes located in all cell compartments and in the extracellular space. Proteases impact all hallmarks of cellular and tissue aging, and the onset and progression of age‐related diseases including neurodegeneration.
Mamta Rai, Michelle Curley, Zane Coleman, Fabio Demontis   +3 more
wiley   +1 more source

A diverse uncultivated microbial community is responsible for organic matter degradation in the Black Sea sulphidic zone

Environmental Microbiology, Volume 23, Issue 6, Page 2709-2728, June 2021., 2021
Summary Organic matter degradation in marine environments is essential for the recycling of nutrients, especially under conditions of anoxia where organic matter tends to accumulate. However, little is known about the diversity of the microbial communities responsible for the mineralization of organic matter in the absence of oxygen, as well as the ...
Saara Suominen, Nina Dombrowski, Jaap S. Sinninghe Damsté, Laura Villanueva   +3 more
wiley   +1 more source

Dipeptidyl‐peptidases: Key enzymes producing entry forms of extracellular proteins in asaccharolytic periodontopathic bacterium Porphyromonas gingivalis

Molecular Oral Microbiology, Volume 36, Issue 2, Page 145-156, April 2021., 2021
Abstract Porphyromonas gingivalis, a pathogen of chronic periodontitis, is an asaccharolytic microorganism that solely utilizes nutritional amino acids as its energy source and cellular constituents. The bacterium is considered to incorporate proteinaceous nutrients mainly as dipeptides, thus exopeptidases that produce dipeptides from polypeptides are ...
Takayuki K. Nemoto, Yuko Ohara Nemoto
wiley   +1 more source

Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases

FEBS Letters, 1998
We show by site‐directed mutagenesis that the catalytic residues of mammalian legumain, a recently discovered lysosomal asparaginycysteine endopeptidase, form a catalytic dyad in the motif His‐Gly‐spacer‐Ala‐Cys. We note that the same motif is present in the caspases, aspartate‐specific endopeptidases central to the process of apoptosis in animal cells,
Chen, Jinq-May, Rawlings, Neil D., Stevens, Richard A.E., Barrett, Alan J.   +3 more
openaire   +2 more sources

Zebrafish as a new model to study effects of periodontal pathogens on cardiovascular diseases. [PDF]

, 2016
Porphyromonas gingivalis (Pg) is a keystone pathogen in the aetiology of chronic periodontitis. However, recent evidence suggests that the bacterium is also able to enter the bloodstream, interact with host cells and tissues, and ultimately contribute to
A Haraguchi, A Singh, AH Meijer, AL Griffen, AM Louhelainen, AM van der Sar, BM Hogan, BR Dorn, BR Dorn, CA Genco, CO Igboin, D Grenier, DM Castillo, EV Kozarov, G Hajishengallis, G Hajishengallis, G Hajishengallis, H Inaba, IM Velsko, J Potempa, J Potempa, J Slots, JT Singer, K Wada, KA Nguyen, KE Nelson, KJ Clark, KJ Maresz, L Li, L Reyes, M Benedyk, M Hashimoto, M Rapala-Kozik, M Sztukowska, MK Brannon, ML Laine, NE Fiehn, PR Blackburn, RC Williams, RG Deshpande, SM Sheets, SM Sheets, T Abe, T Imamura, T Kadowaki, TD Herath, TK Prajsnar, TK Prajsnar, TR Mikuls, VI Haraszthy, Y Guo, Y Kumagai   +51 more
core   +2 more sources

Synthesis of Sphingolipids Impacts Survival of Porphyromonas gingivalis and the Presentation of Surface Polysaccharides [PDF]

, 2016
Bacteria alter the biophysical properties of their membrane lipids in response to environmental cues, such as shifts in pH or temperature. In essence, lipid composition determines membrane structure, which in turn influences many basic functions, such as
Floyd Dewhirst, Floyd Dewhirst, Frank Nichols, Kornelija Valiuskyte, Mary Ellen Davey, Zachary Daniel Moye   +5 more
core   +2 more sources

Clan CD of cysteine peptidases as an example of evolutionary divergences in related protein families across plant clades [PDF]

, 2010
Comparative genomic analyses are powerful tools that can be used to analyze the presence, conservation, and evolution of protein families and to elucidate issues concerning their function.
Abascal, Acosta-Garcia, Anisimova, Aravind, Archibald, Baum, Beers, Belenghi, Bidle, Bonneau, Bozhkov, Capron, Castresana, Chen, Chowdhury, Coppinger, Edgar, Eichinger, Eisenhaber, Eisenhaber, Francisco J. Garcia, Garcia-Lorenzo, Gonzalez, Guindon, Hara-Nishimura, Hatsugai, Hatsugai, Hoeberichts, Ines Cambra, Kato, Labrou, Lewis, Liu, Lupardus, Manuel Martinez, Martinez, Misumi, Muntz, Nedelcu, Okamoto, Orlean, Palenik, Papi, Queralt, Queralt, Rawlings, Reyes-Prieto, Reyes-Prieto, Rojo, Sanmartin, Schindelman, Shimada, Suarez, Tamura, Uhlmann, Uren, Vercammen, Vercammen, Vercammen, Walker, Watanabe, Waterhouse, Zacks   +62 more
core   +2 more sources