MicroED structure of the C11 cysteine protease clostripain. [PDF]
Clostripain secreted from Clostridium histolyticum is the founding member of the C11 family of Clan CD cysteine peptidases, which is an important group of peptidases secreted by numerous bacteria.
Bu, Guanhong +3 more
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Ecological, beneficial, and pathogenic functions of the Type 9 Secretion System
Microbial Biotechnology, Volume 17, Issue 6, June 2024.This mini review delves into the broad spectrum of proteins secreted by the bacterial type 9 secretion system (T9SS). It focuses on the roles of T9SS‐secreted proteins in pathogenesis, bacterial interactions, host colonization, and the maintenance of ecosystem health.
Sofia T. Rocha +2 more
wiley +1 more source
Reviews in Medical Virology, Volume 34, Issue 3, May 2024.Abstract COVID‐19 as a pan‐epidemic is waning but there it is imperative to understand virus interaction with oral tissues and oral inflammatory diseases. We review periodontal disease (PD), a common inflammatory oral disease, as a driver of COVID‐19 and oral post‐acute‐sequelae conditions (PASC). Oral PASC identifies with PD, loss of teeth, dysgeusia,
Joel Schwartz +4 more
wiley +1 more source
Bacterial protease uses distinct thermodynamic signatures for substrate recognition. [PDF]
, 2017 Porphyromonas gingivalis and Porphyromonas endodontalis are important bacteria related to periodontitis, the most common chronic inflammatory disease in humans worldwide.
Bezerra, GA +8 more
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Modes of inhibition of cysteine proteases [PDF]
, 2004 Cysteine proteases are involved in many physiological processes and their hyperactivity may lead to severe diseases. Nature has developed various strategies to protect cells and whole organisms against undesired proteolysis. One of them is the control of
Chmiel, Dorota +2 more
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Porphyromonas gingivalis peptidylarginine deiminase in the aetiology of rheumatoid arthritis [PDF]
, 2017 Anti-citrullinated protein antibodies (ACPA) are the main autoantibodies in rheumatoid arthritis (RA). Citrullination is the conversion of arginine to citrulline by peptidylarginine deiminase (PAD) enzymes. Periodontitis (PD) is a risk factor for RA, and
Montgomery, Anna B
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Porphyromonas gingivalis gingipains induce a pro-inflammatory extracellular microenvironment : the role of PAR-2 and fibronectin. [PDF]
, 2016 Periodontitis is a chronic inflammatory disease that is characterized by severe tissue destruction of the gingiva and other tooth supporting structures; if left untreated, tooth loss and disintegration of the alveolar bone occurs.
Marschall, Jeffrey S.
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Porphyromonas gingivalis gingipains cause defective macrophage migration towards apoptotic cells and inhibit phagocytosis of primary apoptotic neutrophils [PDF]
Resolution of inflammation involves suppression of inflammatory cell infiltration, effective clearance of apoptotic cells and induction of an anti-inflammatory response thereby re-establishing tissue homeostasis.
Ajay Castro, Sowmya
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The Responses of Human Neutrophils to Tobacco Smoke Components [PDF]
, 2012 Indiana University-Purdue University Indianapolis (IUPUI)Tobacco smoking is considered a major modifiable risk factor for periodontal disease. Tobacco contains about 6700 compounds and almost 4000 compounds of these have been identified in tobacco smoke.
Al-Shibani, Nouf Khider
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Interactions of porphyromonas gingivalis with bone marrow cells: implications on mediators of bone resorption [PDF]
, 2012 PhDPeriodontitis is a multi-factorial disease characterised by the loss of connective tissue and underlying alveolar bone leading to the loss of teeth. Porphyromonas gingivalis (P.
Reddi, Durga
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