Results 141 to 150 of about 2,402 (156)
Some of the next articles are maybe not open access.
Arg-gingipain and Lys-gingipain: a novel class of cysteine proteinases
1999Porphyromonas gingivalis, a Gram-negative anaerobic bacterium, is thought to be a major etiologic bacterium associated with several periodontal diseases including chronic adult periodontitis, generalized juvenile periodontitis, periodontal abscess and refractory periodontitis.
Kenji Yamamoto +2 more
openaire +1 more source
Roles of Gingipains in Periodontal Bone Loss
Journal of Oral Biosciences, 2011Abstract Gingipains are cysteine proteases produced by Porphyromonas gingivalis , one of the major pathogens of periodontitis. They are classified into lysine-specific gingipain (Kgp) and arginine-specific gingipains (Rgps) by the specificity of the proteolytic cutting sites.
Rika Yasuhara, Yoichi Miyamoto
openaire +1 more source
“GINGIPAINS”- A Pathogenic Virulent Factor For Periodontal Diseases
Indian Journal of Applied Research, 2011Porphyromonas gingivalis has been considered as a major etiological agent in the pathogenesis of chronic periodontitis. A number of potential virulence factors associated with this disease may contribute to its initiation. Proteolytic enzymes produced by P.gingivalis being of particular interest because of their production in large quantities.
Dr. Anvitha Sharath Kumar +1 more
openaire +1 more source
Enzymatic Characteristics and Activities of Gingipains from Porphyromonas gingivalis
2020Porphyromonas gingivalis is a gram-negative, rod-shaped, nonmotile bacterium belonging to the phylum Bacteroidetes. It produces abundant amounts of proteases in both cell-associated and secretory forms, including a group of cysteine proteases referred to as gingipains, which have attracted much attention due to their high proteolytic activity ...
openaire +2 more sources
The Secretion and Maturation Journey of Gingipains
Molecular Oral MicrobiologyABSTRACTMultifunctional gingipains are trypsin‐like enzymes secreted extracellularly by Porphyromonas gingivalis, which require delicate transit and processing to be activated in different mature forms. This review manages to reconstruct each processing step including the specific cleavage sites and relative proteins or helpers. Errors in any steps can
Zixue Lei +3 more
openaire +1 more source
Porphyromonas gingivalis Gingipains: The Molecular Teeth of a Microbial Vampire
Current Protein & Peptide Science, 2003The gingipains are cell surface Arg- and Lys-specific proteinases of the bacterium Porphyromons gingivalis, which has been associated with periodontitis, a disease that results in the destruction of the teeth-s supporting tissues. The proteinases are encoded by three genes designated rgpA, rgpB and kgp.
N M, O-Brien-Simpson +3 more
openaire +2 more sources
Gingipain adhesin domains mediate Porphyromonas gingivalis adherence to epithelial cells
Microbial Pathogenesis, 2004Porphyromonas gingivalis, a Gram-negative oral anaerobe, interacts with epithelium lining the gingival sulcus. Continuing our studies on the role of gingipain cysteine proteinases in P. gingivalis adherence to epithelial cells, we showed that antibody raised to the recombinant adhesin domain of arg-gingipain A blocked bacterial attachment, providing ...
Tsute, Chen, Margaret J, Duncan
openaire +2 more sources
The Role of Gingipains in the Pathogenesis of Periodontal Disease
Journal of Periodontology, 2003Gingipains are trypsin‐like cysteine proteinases produced by Porphyromonas gingivalis, a major causative bacterium of adult periodontitis. HRgpA (95 kDa) and RgpB (50 kDa), products of 2 distinct but related genes, rgpA and rgpB, respectively, are specific for Arg‐Xaa peptide bonds. Kgp, a product of the kgp gene, is specific for Lys‐Xaa bonds.
openaire +2 more sources
Molecular Genetics of Porphyromonas gingivalis: Gingipains and other Virulence Factors
Current Protein & Peptide Science, 2003Porphyromonas gingivalis is a black-pigmented anaerobic gram-negative bacterium that is a major pathogen of chronic adult periodontitis, an inflammatory disease of tooth-supporting tissues. P. gingivalis possesses a number of potential virulence factors.
openaire +2 more sources
DX‐9065a inhibits proinflammatory events induced by gingipains and factor Xa
Journal of Periodontal Research, 2006Objective: Arginine‐specific cysteine proteases (Rgps) from Porphyromonas gingivalis are important virulent factors of periodontal diseases. However, there is no therapeutic drug that inhibits proinflammatory events induced by these enzymes. In this study, we investigated proinflammatory activities of Rgps and activated coagulation factor X (FXa) and ...
Kenji, Matsushita +5 more
openaire +2 more sources