Results 1 to 10 of about 52,654 (304)

CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis. [PDF]

Cell Commun Signal, 2023
Abstract Background Cementoblasts are tooth-root surface-lining cells responsible for cementum formation (cementogenesis) and sensitive to Porphyromonas gingivalis stimulation. We have previously proved transcription factor CXXC-type zinc finger protein 5 (CXXC5) participates in cementogenesis.
Ma L, Wang H, Huang X, Huang H, Peng Y, Liu H, Wang X, Cao Z.   +7 more
europepmc   +4 more sources

P. GINGIVALIS–LPS-INDUCED NLRP3 INFLAMMASOME ACTIVATION DRIVES AD PATHOLOGIES [PDF]

Innov Aging, 2023
Abstract Alzheimer’s disease (AD) is the leading cause of dementia among older adults. AD is characterized by amyloid-β deposition, abnormal hyperphosphorylation of tau leading to the formation of neurofibrillary tangles, and neuroinflammation. Porphyromonas gingivalis, the keystone-pathogen of periodontitis, is being increasingly linked
Verma, Ambika, Patyal, Pankaj, Azhar, Gohar, Wei, Jeanne   +3 more
europepmc   +2 more sources

Curry Leaf Triggers Cell Death of P. gingivalis with Membrane Blebbing. [PDF]

Pathogens, 2021
Periodontal disease has become a serious public health problem, as indicated by accumulating evidence that periodontal disease is not only a major cause of tooth loss but is also associated with various systemic diseases. The present study assessed the anti-bacterial activities of three herbal products (curry leaf, clove, and cinnamon) against ...
Nakao R, Ikeda T, Furukawa S, Morinaga Y.   +3 more
europepmc   +5 more sources

Predicting Key Genes and Therapeutic Molecular Modelling to Explain the Association between Porphyromonas gingivalis (P. gingivalis) and Alzheimer's Disease (AD). [PDF]

Int J Mol Sci, 2023
The association between Porphyromonas gingivalis (P. gingivalis) and Alzheimer’s disease (AD) remains unclear. The major aim of this study was to elucidate the role of genes and molecular targets in P. gingivalis-associated AD. Two Gene Expression Omnibus (GEO) datasets, GSE5281 for AD (n = 84 Alzheimer’s, n = 74 control) and GSE9723 (n = 4 P ...
Hamarsha A, Balachandran K, Sailan AT, Nasruddin NS.   +3 more
europepmc   +3 more sources

<i>P. gingivalis</i>-Infected Macrophage Extracellular Vesicles Cause Adverse Pregnancy Outcomes. [PDF]

J Dent Res
Periodontitis is a chronic inflammatory disease triggered by oral bacterial infection, with the bacterium Porphyromonas gingivalis being a major causative agent. The association between periodontitis and various systemic diseases has been demonstrated.
Tanai A, Fukuhara Y, Eguchi T, Kawai H, Ueda K, Ochiai K, Ikegame M, Okamoto K, Okamura H.   +8 more
europepmc   +3 more sources

P. gingivalis alters lung microbiota and aggravates disease severity of COPD rats by up-regulating Hsp90α/MLKL [PDF]

Journal of Oral Microbiology
Background Epidemiological evidence has confirmed that periodontitis is an essential and independent risk factor of chronic obstructive pulmonary disease (COPD).
Nan Feng, Xuan Han, Da Peng, Fengxue Geng, Qian Li, Chunlin Pan, Hongyan Wang, Yaping Pan, Lisi Tan   +8 more
doaj   +2 more sources

Mechanisms of Porphyromonas gingivalis to translocate over the oral mucosa and other tissue barriers

Journal of Oral Microbiology, 2023
Introduction The oral pathogen Porphyromonas gingivalis is not only associated with periodontitis but also with systemic diseases elsewhere in the body. The mechanisms by which P.
Caroline A. de Jongh, Teun J. de Vries, Floris J. Bikker, Susan Gibbs, Bastiaan P. Krom   +4 more
doaj   +1 more source

Intraspecies Variability Affects Heterotypic Biofilms of Porphyromonas gingivalis and Prevotella intermedia: Evidences of Strain-Dependence Biofilm Modulation by Physical Contact and by Released Soluble Factors. [PDF]

PLoS ONE, 2015
It is well known that strain and virulence diversity exist within the population structure of Porphyromonas gingivalis. In the present study we investigate intra- and inter-species variability in biofilm formation of Porphyromonas gingivalis and partners
Graziela Murta Barbosa, Andrea Vieira Colombo, Paulo Henrique Rodrigues, Maria Regina Lorenzetti Simionato   +3 more
doaj   +1 more source

Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

International Journal of Oral Science, 2023
Bacteremia induced by periodontal infection is an important factor for periodontitis to threaten general health. P. gingivalis DNA/virulence factors have been found in the brain tissues from patients with Alzheimer’s disease (AD). The blood-brain barrier
Shuang Lei, Jian Li, Jingjun Yu, Fulong Li, Yaping Pan, Xu Chen, Chunliang Ma, Weidong Zhao, Xiaolin Tang   +8 more
doaj   +1 more source

Clinical significance and prognostic value of Porphyromonas gingivalis infection in lung cancer

Translational Oncology, 2021
A variety of pathogenic microorganisms can promote the occurrence and development of malignant tumors by colonizing in the body. It has been shown that Porphyromonas gingivalis (P.
Yiwen Liu, Xiang Yuan, Kuisheng Chen, Fuyou Zhou, Haijun Yang, Hong Yang, Yijun Qi, Jinyu Kong, Wei Sun, Shegan Gao   +9 more
doaj   +1 more source