P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress. [PDF]
Int J Mol Sci, 2023 Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontitis, is associated with neuroinflammation. Periodontal disease increases with age; 70.1% of adults 65 years and older have periodontal problems. However, the P.
Verma A +7 more
europepmc +2 more sources
The P. gingivalis Autocitrullinome Is Not a Target for ACPA in Early Rheumatoid Arthritis [PDF]
Journal of Dental Research, 2020 Rheumatoid arthritis (RA), a chronic inflammatory disease affecting primarily the joints, is frequently characterized by the presence of autoimmune anticitrullinated protein antibodies (ACPA) during preclinical stages of disease and accumulation of ...
E. Muñoz-Atienza +6 more
semanticscholar +3 more sources
Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis [PDF]
International Immunopharmacology, 2008 Summary Antibody titers to P. gingivalis are increased in patients with rheumatoid arthritis and are associated with disease-specific autoimmunity. Background Periodontitis (PD) has been implicated as a risk factor for rheumatoid arthritis (RA).
T. Mikuls +8 more
semanticscholar +3 more sources
Localization of P. gingivalis in Preterm Delivery Placenta [PDF]
Journal of Dental Research, 2009 Increasing evidence suggests an association between periodontal disease and adverse pregnancy outcomes. Although infection is considered as a risk factor for preterm delivery, the localization of oral bacteria or their antigens in chorioamnionitis placental tissue has never been demonstrated.
J. Katz +3 more
semanticscholar +3 more sources
CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis. [PDF]
Cell Commun Signal, 2023 Abstract Background Cementoblasts are tooth-root surface-lining cells responsible for cementum formation (cementogenesis) and sensitive to Porphyromonas gingivalis stimulation. We have previously proved transcription factor CXXC-type zinc finger protein 5 (CXXC5) participates in cementogenesis.
Ma L +7 more
europepmc +4 more sources
P. gingivalis Modulates Keratinocytes through FOXO Transcription Factors
PLoS ONE, 2013 P. gingivalis is a prominent periodontal pathogen that has potent effects on host cells. In this study we challenged gingival epithelial cells with P.
Shuai Li +6 more
semanticscholar +6 more sources
Effects of Tobacco and P. gingivalis on Gingival Fibroblasts
Journal of Dental Research, 2010 Cigarette smoke condensate (CSC) is the particulate matter of cigarette smoke. Porphyromonas gingivalis ( P. gingivalis) is an opportunistic pathogen involved in periodontitis. It was hypothesized that the combination of CSC and P. gingivalis would increase the collagen-degrading ability of human gingival fibroblasts (HGFs).
W. Zhang, F. Song, L. Windsor
semanticscholar +3 more sources
P. gingivalis interactions with epithelial cells.
Frontiers in Bioscience, 2008 Dental plaque, a microbial biofilm that accumulates on teeth and initiates periodontal disease, is composed of hundreds of different bacterial species within an organized structure. The biofilm bacteria and their byproducts irritate the gingival epithelium and induce an "inflammatory response".
D. Kinane +4 more
semanticscholar +3 more sources
Mechanisms of Porphyromonas gingivalis to translocate over the oral mucosa and other tissue barriers
Journal of Oral Microbiology, 2023 Introduction The oral pathogen Porphyromonas gingivalis is not only associated with periodontitis but also with systemic diseases elsewhere in the body. The mechanisms by which P.
Caroline A. de Jongh +4 more
doaj +1 more source
Intraspecies Variability Affects Heterotypic Biofilms of Porphyromonas gingivalis and Prevotella intermedia: Evidences of Strain-Dependence Biofilm Modulation by Physical Contact and by Released Soluble Factors. [PDF]
PLoS ONE, 2015 It is well known that strain and virulence diversity exist within the population structure of Porphyromonas gingivalis. In the present study we investigate intra- and inter-species variability in biofilm formation of Porphyromonas gingivalis and partners
Graziela Murta Barbosa +3 more
doaj +1 more source