Results 1 to 10 of about 3,291 (136)

Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis. [PDF]

MBio, 2022
Porphyromonas gingivalis, a keystone pathogen in periodontitis (PD), produces cysteine proteases named gingipains (RgpA, RgpB, and Kgp), which strongly affect the host immune system.
Ewelina Dobosz, Barbara Potempa, Richard Lamont   +2 more
exaly   +4 more sources

Arginine-specific gingipains (RgpA/RgpB) knockdown modulates neutrophil machinery

Journal of Oral Microbiology
Background Gingipains are important virulence factors present in Porphyromonas gingivalis. Arginine-specific gingipains (RgpA and RgpB) are critically associated with increased proteolytic activity and immune system dysfunction, including neutrophilic ...
Marinella Holzhausen, Alpdogan Kantarci, Hatice Hasturk   +2 more
exaly   +4 more sources

Discovery of Gingipains and Porphyromonas gingivalis Inhibitors from Food-Derived Natural Products: A Narrative Review [PDF]

Foods
Porphyromonas gingivalis is a key periodontal pathogen whose cysteine proteases, gingipains (Rgp and KGP), are essential for nutrient acquisition and virulence.
Desheng Wu, Xiaofeng Li, Guanglei Zhao, Lisha Hao, Xiaohan Liu   +4 more
doaj   +3 more sources

Heterogeneous Systemic IgG Responses to Porphyromonas gingivalis Gingipains in Advanced Periodontitis [PDF]

Clinical and Experimental Dental Research
Objectives To evaluate serum IgG responses against Porphyromonas gingivalis gingipains RgpB and Kgp in patients with stage III and IV periodontitis and examine associations with clinical periodontal parameters.
Steffen Büttner, Sonja H. M. Derman, Alexander Simonis, Alicia M. Meyer‐Hofmann, Max vonKohout, Manuel Koch, Anna Greta Barbe   +6 more
doaj   +2 more sources

Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains

Journal of Oral Microbiology, 2021
Background: The cell-surface cysteine proteinases RgpA, RgpB (Arg-gingipain), and Kgp (Lys-gingipain) are major virulence factors of P. gingivalis, a keystone pathogen in the development of destructive periodontal disease.
Keith J Cross, Eric C. Reynolds, Christine A Seers   +2 more
exaly   +2 more sources

Gingipains disrupt bone homeostasis via dual regulation of osteogenesis and osteoclastogenesis through exosomal miR-146a-5p/TRAF6 signaling [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundGingipains are virulence factors released by Porphyromonas gingivalis that contribute to periodontal destruction by disrupting bone metabolism.
Jiachen Dong, Jiachen Dong, Jiachen Dong, Yue Liao, Yue Liao, Yue Liao, Mengjun Sun, Mengjun Sun, Mengjun Sun, Huiwen Chen, Huiwen Chen, Huiwen Chen, Kecong Zhou, Kecong Zhou, Kecong Zhou, Huanyu Zhang, Huanyu Zhang, Huanyu Zhang, Wei Zhou, Wei Zhou, Wei Zhou, Zhongchen Song, Zhongchen Song, Zhongchen Song   +23 more
doaj   +2 more sources

Testosterone Modulates Virulence-Associated Phenotypes of Porphyromonas gingivalis W50 [PDF]

Pathogens
Porphyromonas gingivalis is a keystone periodontal pathogen strongly associated with periodontitis progression. Although testosterone levels have been associated with periodontal health, its direct effects on P.
Yvette Amba Kindlund, Rongrong Wu, Kartheyaene Jayaprakash Demirel, Alessandra Neves Guimaraes, Isak Demirel   +4 more
doaj   +2 more sources

S-Nitrosothiols modulate Porphyromonas gingivalis virulence [PDF]

Redox Biology
Porphyromonas gingivalis is the key etiological pathogen of periodontal disease, a chronic oral inflammatory condition that affects over 14% of the global population. P.
Tsian D. Ramrattan, Evan R. Stair, Shreya Dandu, Robert L. Morgan, III, Rajnish Kumar, Quincy K. Snyder, Leslie M. Hicks, Ronit Freeman, Mark H. Schoenfisch   +8 more
doaj   +2 more sources

Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases

Journal of Oral Microbiology, 2014
Gingipains are the major virulence factors of Porphyromonas gingivalis, the main periodontopathogen. It is expected that inhibition of gingipain activity in vivo could prevent or slow down the progression of adult periodontitis.
Ingar Olsen, Jan Potempa
exaly   +3 more sources

Porphromonas gingivalis infection induces gingipain-dependent changes in the brain vasculature of zebrafish larvae [PDF]

Cell Communication and Signaling
Recent studies link infections with blood–brain barrier (BBB) dysfunctions, neuroinflammation and subsequent neurodegeneration. Here, we employed a zebrafish larval model to study the impact of systemic infection with an oral pathogen Porphyromonas ...
Anna Mieszkowska, Magdalena Marcinkowska, Magdalena Widziolek, Jan Potempa, Magdalena Chadzinska   +4 more
doaj   +2 more sources