Results 11 to 20 of about 3,291 (136)

Development of a Simple Protocol for Zymogram-Based Isolation and Characterization of Gingipains from Porphyromonas gingivalis: The Causative Agent of Periodontitis

Applied Sciences, 2023
Gingipains (RgpA, RgpB, and Kgp) are major virulence factors of the periodontitis-causing bacterium Porphyromonas gingivalis. Isolation of gingipains from the crude protein sample of P.
Eng Sze Wei, Ramasamy Kavitha, Mohammad Auwal Sa’ad, Pattabhiraman Lalitha, Neeraj Kumar Fuloria, Manickam Ravichandran, Shivkanya Fuloria   +6 more
doaj   +2 more sources

Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson’s disease brains

npj Parkinson's Disease
Gingipains are protease virulence factors produced by Porphyromonas gingivalis, a Gram-negative bacterium best known for its role in chronic periodontitis. Gingipains were recently identified in the middle temporal gyrus of postmortem Alzheimer’s disease
Florian Ermini, Victoria F. Low, Jennifer J. Song, Adelie Y. S. Tan, Richard L. M. Faull, Michael Dragunow, Maurice A. Curtis, Stephen S. Dominy   +7 more
doaj   +2 more sources

Gingipains protect Porphyromonas gingivalis from macrophage-mediated phagocytic clearance. [PDF]

PLoS Pathogens
Porphyromonas gingivalis (Pg) is a keystone pathogen in periodontitis, a highly prevalent disease manifested by chronic inflammation of the periodontium, alveolar bone resorption and tooth loss.
Magdalena Widziolek, Anna Mieszkowska, Magdalena Marcinkowska, Bartlomiej Salamaga, Justyna Folkert, Krzysztof Rakus, Magdalena Chadzinska, Jan Potempa, Graham P Stafford, Tomasz K Prajsnar, Craig Murdoch   +10 more
doaj   +4 more sources

Porphyromonas gingivalis Suppresses Interferon‐Gamma Signaling in Macrophages Through a Contact‐Dependent, Gingipain‐Mediated Mechanism [PDF]

MicrobiologyOpen
Interferon signaling serves as a crucial defense mechanism for host cells against intracellular pathogens. Interferon‐gamma (IFN‐γ) binding to macrophages impacts the expression of approximately 2000 genes, activating them to enhance intracellular ...
Shotaro Abe, Jun Ohshima, Masayoshi Morita, Nobutake Tanaka, Mikako Hayashi   +4 more
doaj   +2 more sources

Porphyromonas gingivalis induces intestinal inflammation through gingipain-dependent gut microbiome dysbiosis [PDF]

Microbiome
Background Porphyromonas gingivalis (Pg), a key pathogen in periodontitis, is implicated in various systemic diseases such as pancreatic cancer and Alzheimer’s disease. However, as a periodontal pathogen that can directly enter the lower gastrointestinal
Ming Li, Jiyun Cui, Ru Qu, Rulong Liu, Yifan Sun, Ping Li, Juan Liu, Adrian Low, Xiaochang Huang, Fei Gan, Zhenjiang Zech Xu   +10 more
doaj   +2 more sources

Ozone ultrafine bubble water sterilizes Porphyromonas gingivalis and neutralizes its virulence factors. [PDF]

PLoS ONE
Periodontitis is caused by Gram-negative bacteria. Porphyromonas gingivalis, a major Gram-negative periodontal pathogen, produces virulence factors such as gingipains, lipopolysaccharide (LPS), and lipoproteins, which contribute to tissue destruction ...
Mana Endo, Hisanori Domon, Satoru Hirayama, Fumio Takizawa, Akiomi Ushida, Koichi Tabeta, Yutaka Terao   +6 more
doaj   +2 more sources

Genetically engineering Gingipains for high yield large scale purification. [PDF]

, 2023
Porphyromonas gingivalis is a keystone oral pathogen in the progression of periodontal disease and has been implicated in the etiology of many other systemic human diseases. P.
Fuchs, Andrew E.
core   +1 more source

Porphyromonas gingivalis Gingipains Display Transpeptidation Activity

, 2018
Porphyromonas gingivalis is a keystone periodontal pathogen that has been associated with autoimmune disorders. The cell surface proteases Lys-gingipain (Kgp) and Arg-gingipains (RgpA and RgpB) are major virulence factors, and their proteolytic activity ...
Paul D. Veith (792136), Eric C. Reynolds (419911), Dhana G. Gorasia (792135), Lianyi Zhang (419906), Keith J. Cross (419910), N. Laila Huq (419901), Yu-Yen Chen (450567), Christine A. Seers (419902)   +7 more
core   +4 more sources

Coating and Corruption of Human Neutrophils by Bacterial Outer Membrane Vesicles

Microbiology Spectrum, 2022
Porphyromonas gingivalis is a keystone oral pathogen that successfully manipulates the human innate immune defenses, resulting in a chronic proinflammatory state of periodontal tissues and beyond.
Marines du Teil Espina, Yanyan Fu, Demi van der Horst, Claudia Hirschfeld, Marina López-Álvarez, Lianne M. Mulder, Costanza Gscheider, Anna Haider Rubio, Minke Huitema, Dörte Becher, Peter Heeringa, Jan Maarten van Dijl   +11 more
doaj   +1 more source

Proteolysis of Gingival Keratinocyte Cell Surface Proteins by Gingipains Secreted From Porphyromonas gingivalis – Proteomic Insights Into Mechanisms Behind Tissue Damage in the Diseased Gingiva

Frontiers in Microbiology, 2020
Porphyromonas gingivalis, the main etiologic agent of periodontitis, secretes cysteine proteases named gingipains. HRgpA and RgpB gingipains have Arg-specificity, while Kgp gingipain is Lys-specific.
Katarina Hočevar, Katarina Hočevar, Matej Vizovišek, Alicia Wong, Joanna Kozieł, Marko Fonović, Barbara Potempa, Richard J. Lamont, Jan Potempa, Jan Potempa, Boris Turk, Boris Turk   +11 more
doaj   +1 more source