Results 21 to 30 of about 3,291 (136)

Porphyromonas gingivalis-Helicobacter pylori co-incubation enhances Porphyromonas gingivalis virulence and increases migration of infected human oral keratinocytes

Journal of Oral Microbiology, 2022
Background Porphyromonas gingivalis is part of the subgingival biofilm and a keystone species in the development of periodontitis. Interactions between P.gingivalis and other bacteria in biofilms have been shown to affect bacterial virulence ...
Cristopher Soto, Victoria Rojas, Lucas Yáñez, Antonio Hidalgo, Marcela Olivera, Martín Pacheco, Darna Venegas, Daniela Salinas, Denisse Bravo, Andrew F.G. Quest   +9 more
doaj   +1 more source

Gingipains impair attachment of epithelial cell to dental titanium abutment surfaces [PDF]

, 2019
The study investigated in vitro the effect of Porphyromonas gingivalis and its cysteine proteases (gingipains) on epithelial cell adhesion to titanium-zirconium alloy surfaces.
Gadzo, Naida, Potempa, Jan, Naida Gadzo, Tacchi, Manuel, Potempa, Jan,, Anton Sculean, Gadzo, Naida,, Tacchi, Manuel,, Jan Potempa, Stavropoulos, Andreas, Stavropoulos, Andreas,, Sigrun Eick, Andreas Stavropoulos, Sculean, Anton,, Sculean, Anton, Manuel Tacchi, Eick, Sigrun,, Eick, Sigrun   +17 more
core   +4 more sources

Dual Inhibitory Activity of Petroselinic Acid Enriched in Fennel Against Porphyromonas gingivalis

Frontiers in Microbiology, 2022
Increasing evidence has shown that a major periodontal pathobiont, Porphyromonas gingivalis, triggers oral dysbiosis leading to deterioration not only of periodontal health, but also of several systemic conditions.
Nanami Yoshino, Nanami Yoshino, Tsuyoshi Ikeda, Ryoma Nakao   +3 more
doaj   +1 more source

Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C [PDF]

, 2013
Gingipains are cysteine proteases that represent major virulence factors of the periodontopathogenic bacterium Porphyromonas gingivalis. Gingipains are reported to degrade extracellular matrix (ECM) of periodontal tissues, leading to tissue destruction ...
Potempa, Barbara, Potempa, Jan, Ruggiero, Sabrina, Chiquet, Matthias, Cosgarea, Raluca, Eick, Sigrun   +5 more
core   +1 more source

Porphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells

FEBS Open Bio, 2021
Porphyromonas gingivalis (Pg) is a periodontopathic pathogen that may affect MUC5AC‐related mucus hypersecretion along airway epithelial cells. Here, we attempted to establish whether Pg virulence factors (lipopolysaccharide, FimA fimbriae, gingipains ...
Chihiro Miya, Marni E. Cueno, Ryuta Suzuki, Shuichiro Maruoka, Yasuhiro Gon, Tadayoshi Kaneko, Yoshiyuki Yonehara, Kenichi Imai   +7 more
doaj   +1 more source

Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1.

PLoS Pathogens, 2019
Porphyromonas gingivalis is a major pathogen in severe and chronic manifestations of periodontal disease, which is one of the most common infections of humans. A central feature of P.
Hiroki Takeuchi, Naoko Sasaki, Shunsuke Yamaga, Masae Kuboniwa, Michiya Matsusaki, Atsuo Amano   +5 more
doaj   +1 more source

Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon

Microbiology Spectrum, 2022
The type IX secretion system (T9SS) transports cargo proteins through the outer membrane of Bacteroidetes and attaches them to the cell surface for functions including pathogenesis, gliding motility, and degradation of carbon sources.
Dhana G. Gorasia, Ignacio Lunar Silva, Catherine A. Butler, Maïalène Chabalier, Thierry Doan, Eric Cascales, Paul D. Veith, Eric C. Reynolds   +7 more
doaj   +1 more source

Dysregulation of Stress-Induced Translational Control by Porphyromonas gingivalis in Host Cells

Microorganisms, 2023
Porphyromonas gingivalis contributes to the chronic oral disease periodontitis, triggering the activation of host inflammatory responses, inducing cellular stresses such as oxidation. During stress, host cells can activate the Integrated Stress Response (
Alex A. Knowles, Susan G. Campbell, Neil A. Cross, Prachi Stafford   +3 more
doaj   +1 more source

Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner

Frontiers in Cellular and Infection Microbiology, 2017
Gingipain cysteine proteases are considered key virulence factors of Porphyromonas gingivalis. They significantly influence antibacterial and homeostatic functions of macrophages, neutrophils, the complement system, and cytokine networks.
Jan Potempa, Jan Potempa, Joanna Koziel, Izabela Glowczyk, Alicia Wong, Barbara Potempa, Olena Babyak, Maciej Lech, Maciej Lech, Richard J. Lamont   +9 more
doaj   +1 more source

Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson’s Disease

Biomolecules, 2020
Neuronal lesions in Parkinson’s disease (PD) are commonly associated with α-synuclein (α-Syn)-induced cell damage that are present both in the central and peripheral nervous systems of patients, with the enteric nervous system also being especially ...
Marthinus Janse van Vuuren, Theodore Albertus Nell, Jonathan Ambrose Carr, Douglas B. Kell, Etheresia Pretorius   +4 more
doaj   +1 more source