Results 41 to 50 of about 3,291 (136)

Porphyromonas gingivalis gingipains induce a pro-inflammatory extracellular microenvironment : the role of PAR-2 and fibronectin. [PDF]

, 2016
Periodontitis is a chronic inflammatory disease that is characterized by severe tissue destruction of the gingiva and other tooth supporting structures; if left untreated, tooth loss and disintegration of the alveolar bone occurs.
Marschall, Jeffrey S.
core   +1 more source

Synergism of Gingipains in Endothelial Cell Adhesion Disruption and Apoptosis [PDF]

, 2006
The presence of Porphyromonas gingivalisin the periodontal pocket and the high levels of gingipain activity detected in gingival crevicular fluid could implicate a role for gingipains in the destruction of the highly vascular periodontal tissue.
Sheets, Shaun Michellee
core   +1 more source

Gingipains impair cognition: an animal study

, 2023
Aims: Blood-brain barrier (BBB) disorder is one of the early findings in cognitive impairments. We have recently found that Porphyromonas gingivalis (P. gingivalis) bacteremia can cause cognitive impairment and increased BBB permeability.
Fulong Li (16029044)
core   +1 more source

Proposed model of how P. gingivalis gingipains send bacterial virulence factors through the gingival epithelium.

, 2019
P. gingivalis gingipains degrade JAM1, which increases the permeability of gingival epithelium to gingipains and other factors. Subsequently, gingipains are transferred to the deeper epithelium to further degrade JAM1, which allows LPS and PGN to ...
Atsuo Amano (256770), Masae Kuboniwa (280124), Michiya Matsusaki (1532488), Hiroki Takeuchi (217612), Shunsuke Yamaga (7833236), Naoko Sasaki (773945)   +5 more
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Gingipains from Porphyromonas gingivalis W83 Synergistically Disrupt Endothelial Cell Adhesion and Can Induce Caspase-Independent Apoptosis

, 2006
We have shown previously that gingipains from Porphyromonas gingivalis W83 can induce cell detachment, cell adhesion molecule (CAM) cleavage, and apoptosis in endothelial cells; however, the specific roles of the individual gingipains are unclear.
Travis, James, Potempa, Jan, Carlos A. Casiano, Casiano, Carlos A., James Travis, Fletcher, Hansel M., Shaun M. Sheets, Hansel M. Fletcher, Jan Potempa, Sheets, Shaun M.   +9 more
core   +1 more source

Role of Porphyromonas gingivalis gingipains in multi-species biofilm formation [PDF]

, 2014
BackgroundPeriodontal diseases are polymicrobial diseases that cause the inflammatory destruction of the tooth-supporting (periodontal) tissues. Their initiation is attributed to the formation of subgingival biofilms that stimulate a cascade of chronic ...
Bao, Kai, Aduse-Opoku, J, Joseph Aduse-Opoku, Aduse-Opoku, Joseph, Curtis, Michael A, Belibasakis, Georgios N, Curtis, MA, Georgios N Belibasakis, Nagihan Bostanci, Bao, K, Thurnheer, Thomas, Bostanci, N, Kai Bao, Belibasakis, GN, Thomas Thurnheer, Michael A Curtis, Thurnheer, T, Bostanci, Nagihan   +17 more
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Parkinson’s Disease: A Systemic Inflammatory Disease Accompanied by Bacterial Inflammagens

Frontiers in Aging Neuroscience, 2019
Parkinson’s disease (PD) is a well-known neurodegenerative disease with a strong association established with systemic inflammation. Recently, the role of the gingipain protease group from Porphyromonas gingivalis was implicated in Alzheimer’s disease ...
Büin Adams, J. Massimo Nunes, Martin J. Page, Timothy Roberts, Timothy Roberts, Jonathan Carr, Theo A. Nell, Douglas B. Kell, Douglas B. Kell, Etheresia Pretorius   +9 more
doaj   +1 more source

Heme Competition Triggers an Increase in the Pathogenic Potential of Porphyromonas gingivalis in Porphyromonas gingivalis-Candida albicans Mixed Biofilm

Frontiers in Microbiology, 2020
As one of the main pathogens of periodontitis, Porphyromonas gingivalis often forms mixed biofilms with other bacteria or fungi under the gingiva, such as Candida albicans. Heme is an important iron source for P. gingivalis and C.
Yanyang Guo, Yu Wang, Yijin Wang, Yabing Jin, Chen Wang   +4 more
doaj   +1 more source

Interactions of porphyromonas gingivalis with bone marrow cells: implications on mediators of bone resorption [PDF]

, 2012
PhDPeriodontitis is a multi-factorial disease characterised by the loss of connective tissue and underlying alveolar bone leading to the loss of teeth. Porphyromonas gingivalis (P.
Reddi, Durga
core   +4 more sources

Porphyromonas gingivalis and Treponema denticola synergistic polymicrobial biofilm development. [PDF]

PLoS ONE, 2013
Chronic periodontitis has a polymicrobial biofilm aetiology and interactions between key bacterial species are strongly implicated as contributing to disease progression.
Ying Zhu, Stuart G Dashper, Yu-Yen Chen, Simon Crawford, Nada Slakeski, Eric C Reynolds   +5 more
doaj   +1 more source