Results 61 to 70 of about 3,291 (136)

Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors

Frontiers in Cellular and Infection Microbiology, 2019
Periodontitis is a common intraoral infection and is inextricably linked to systemic diseases. Recently, the regulation between host immunologic response and periodontal pathogens has become a hotspot to explain the mechanism of periodontitis and related
Lu Jia, Nannan Han, Juan Du, Lijia Guo, Zhenhua Luo, Yi Liu   +5 more
doaj   +1 more source

Role of Porphyromonas gingivalis Gingipains in Caspase-1 Activation and Phagocytosis of Tannerella forsythia [PDF]

, 2016
학위논문 (박사)-- 서울대학교 대학원 : 치의학대학원 치의과학과 분자미생물치의학전공, 2016. 2. 최봉규.Objectives In the pathogenesis of periodontitis, Porphyromonas gingivalis plays a role as a keystone pathogen that dysregulates host immune responses and results in dysbiosis in oral microbial
정영정
core  

Porphyromonas Gingivalis Survives In BMECs By Kgp Inhibiting Lysosomal Acidification

International Dental Journal
Aim or purpose: This study aimed to investigate Porphyromonas gingivalis (P. gingivalis) persistence in human brain microvascular endothelial cells (BMECs), its impact on cellular lysosomal acidification and regulatory mechanisms, given that brain ...
Angu Li, Xiaolin Tang
doaj   +1 more source

Biphasic Effect of Gingipains from Porphyromonas gingivalis on the Human Complement System.

, 2007
Periodontitis is an inflammatory disease of the supporting structures of the teeth and is caused by, among other agents, Porphyromonas gingivalis. P. gingivalis is very resistant to killing by human complement, which is present in a gingival fluid at 70%
Blom, Anna M., Popadiak, Katarzyna, Blom, Anna, Potempa, Jan, Riesbeck, Kristian   +4 more
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Lipoprotein modifications by gingipains of Porphyromonas gingivalis

, 2018
Background and Objective: Several studies have shown an association between periodontitis and cardiovascular disease (CVD). Atherosclerosis is the major cause of CVD, and a key event in the development of atherosclerosis is accumulation of lipoproteins ...
Karlsson, Helen, T. Bengtsson, Klarström-Engström, Kristin,, S. Ljunggren, Bengtsson, Torbjörn,, Ljunggren, Stefan,, Klarstrom-Engstrom, K., Bengtsson, T.,, Lönn, Johanna, J. Lönn, Lönn, Johanna,, Ljunggren, S.,, Klarstrom-Engstrom, K.,, H. Karlsson, Ljunggren, Stefan, Demirel, I., Demirel, Isak, Karlsson, H.,, Demirel, Isak,, Lönn, J., Bengtsson, T., I. Demirel, Demirel, I.,, K. Klarström-Engström, Klarström-Engström, Kristin, Lönn, J.,, Karlsson, Helen,, Bengtsson, Torbjörn   +27 more
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Porphyromonas gingivalis-Associated Modulation of β-Catenin Signaling in Oral Squamous Cell Carcinoma: Molecular Perspectives from Periodontal Dysbiosis

Molecules
Periodontal disease and oral squamous cell carcinoma (OSCC) are highly prevalent conditions that contribute substantially to global morbidity, as documented by recent Global Burden of Disease analyses.
Nada Tawfig Hashim, Rasha Babiker, Riham Mohammed, Mariam Elsheikh, Vivek Padmanabhan, Md Sofiqul Islam, Malaz Gesm Elseed, Nallan C. S. K. Chaitanya, Bogahawatte Samarakoon Mudiyanselage Samadarani Siriwardena, Muhammed Mustahsen Rahman, Bakri Gobara Gismalla   +10 more
doaj   +1 more source

Interpain A and gingipains act synergistically.

, 2013
Mannan was immobilized on microtiter plates and allowed to activate 4% NHS containing 350 nM InpA and three gingipains, Kgp (44 nM), RgpB (55 nM), HRgpA (33 nM), alone or mixed together.
Tomasz Kantyka (374233), Ky-Anh Nguyen (19852), Kristian Riesbeck (112775), Anna M. Blom (53233), Jan Potempa (19854), Katarzyna Wawrzonek (374234), Katarzyna Popadiak (374236), Michal Potempa (374232), Surya P. Manandhar (374235), Sigrun Eick (326398)   +9 more
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Adsorption of Components of the Plasma Kinin-forming System on the Surface of Porphyromonas gingivalis Involves Gingipains as the Major Docking Platforms

, 2010
Enhanced production of proinflammatory bradykinin-related peptides, the kinins, has been suggested to contribute to the pathogenesis of periodontitis, a common inflammatory disease of human gingival tissues.
Andrzej Kozik, Sroka, Aneta, Kozik, Andrzej, Potempa, Jan, Karkowska-Kuleta, Justyna, Grazyna Bras, Rapala-Kozik, Maria, Aneta Sroka, Jan Potempa, Ky-Anh Nguyen, Sigrun Eick, Bras, Grazyna, Rąpała-Kozik, Maria, Nguyen, Ky-Anh, Barbara Chruscicka, Herwald, Heiko, Maria Rapala-Kozik, Justyna Karkowska-Kuleta, Heiko Herwald, Chruscicka, Barbara, Eick, Sigrun   +20 more
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Supplementary Material for: High Molecular Weight Gingipains from Porphyromonas gingivalis Induce Cytokine Responses from Human Macrophage-Like Cells via a Nonproteolytic Mechanism

, 2017
Periodontal disease is an oral inflammatory disease affecting the supporting structures of teeth. Porphyromonas gingivalis, a major pathogenic agent for the disease, expresses a number of virulence factors, including cysteine proteases called the ...
Aprico A. (4119442), Mackie E.J. (4119439), Pagel C.N. (4119433), Potempa J. (2935359), Fitzpatrick R.E. (4119448), Wong D.M. (4119436), Pike R.N. (4119430), Wijeyewickrema L.C. (4119445)   +7 more
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Porphyromonas gingivalis gingipains cause defective macrophage migration towards apoptotic cells and inhibit phagocytosis of primary apoptotic neutrophils [PDF]

Resolution of inflammation involves suppression of inflammatory cell infiltration, effective clearance of apoptotic cells and induction of an anti-inflammatory response thereby re-establishing tissue homeostasis.
Ajay Castro, Sowmya
core   +5 more sources