Results 71 to 80 of about 3,291 (136)

The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease

Journal of Immunology Research, 2017
Proteinase-activated receptors 1 (PAR1) and 2 (PAR2) are the most highly expressed members of the PAR family in the periodontium. These receptors regulate periodontal inflammatory and repair processes through their activation by endogenous and bacterial ...
E. S. Rovai, M. Holzhausen
doaj   +1 more source

Prospects for treatment of Porphyromonas gingivalis-mediated disease – immune-based therapy

Journal of Oral Microbiology, 2015
Chronic periodontitis is an inflammatory disease of the supporting tissues of the teeth associated with a polymicrobial biofilm (subgingival plaque) accreted to the tooth which results in destruction of the tooth's supporting tissues.
Eric C. Reynolds, Neil O'Brien-Simpson, Tony Rowe, Andrew Nash, Jackie McCluskey, Didier Vingadassalom, Harold Kleanthous   +6 more
doaj   +1 more source

Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism

BMC Microbiology, 2009
Background The oral pathogen Porphyromonas gingivalis has been shown to modulate apoptosis in different cell types, but its effect on epithelial cells remains unclear. Results We demonstrate that primary human gingival epithelial cells (HGECs) challenged
Garcia Carlos A, Benakanakere Manjunatha R, Galicia Johnah C, Stathopoulou Panagiota G, Potempa Jan, Kinane Denis F   +5 more
doaj   +1 more source

Identification of a new membrane-associated protein that influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis

, 2005
C1 - Journal Articles RefereedThe dual membrane envelopes of Gram-negative bacteria provide two barriers of unlike nature that regulate the transport of molecules into and out of organisms.
Yukitake, H, Nakayama, K, Naito, M, Veith, PD, Reynolds, EC, Sakai, E, Okamoto, K, Shoji, M, Ohara, N, Sato, K, Kikuchi, Y   +10 more
core   +1 more source

Exploring the Sn Binding Pockets in Gingipains by Newly Developed Inhibitors:  Structure-Based Design, Chemistry, and Activity

, 2016
Arg-gingipains (Rgps) and Lys-gingipain (Kgp) are cysteine proteinases secreted by Porphyromonas gingivalis, the major pathogen implicated in periodontal disease.
Daniel Krowarsch (2320273), Arkadiusz Białas (2648359), Jacek Otlewski (530513), Artur Mucha (1338465), Jolanta Grembecka (474873), Jan Potempa (19854)   +5 more
core   +1 more source

P. gingivalis-induced aggregation and ros production in whole blood is dependent on gingipains

, 2012
A large body of data accumulated over the past several years suggests that the periodontal pathogen Porphyromonas gingivalis is associated with cardiovascular disease.
Lönn, Johanna,, Hallström, J.,, Bengtsson, Torbjörn,   +2 more
core  

Functional analysis of the gingipains from Porphyromonas gingivalis and their role in periodontal disease

, 2011
Periodontal disease is a major health burden with a huge economic cost. Every culture in the world exhibits signs of some form of the disease and periodontal diseases are a primary cause of tooth loss in man.
Fitzpatrick, Rebecca Elsie
core  

Virulence diversity among <i>Porphyromonas gingivalis</i> strains: a review of genetic factors. [PDF]

J Oral Microbiol
Ahmadi H, Burks J, Innamorati KA, Ehrlich GD, Progulske-Fox A.   +4 more
europepmc   +1 more source

Oral Microbial Extracellular Vesicles as Novel Mediators of Alzheimer's Pathogenesis: A Critical Review of the Periodontal-Brain Axis. [PDF]

Neurotox Res
Alavi SE, Ebrahimi Shahmabadi H, Love RM, Kurumathur AV, Sharma LA, Sharma A.   +5 more
europepmc   +1 more source

From Periodontal Pocket to Systemic Diseases: Mechanistic Insights Into the Role of Porphyromonas gingivalis in Host Pathology. [PDF]

J Cell Mol Med
Basalim AA, Lu EM.
europepmc   +1 more source