Results 31 to 40 of about 3,291 (136)

Research progress on the pathogenicity of Porphyromonas gingivalis clinical strains

口腔疾病防治, 2023
Porphyromonas gingivalis (P. gingivalis) is closely related to the occurrence and development of periodontitis. It is considered to be one of the important pathogens leading to alveolar bone resorption. At present, research on P. gingivalis mostly adopts
WU Yajie , LI Yuqing, ZHOU Fangjie, LI Jiyao   +3 more
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The impact of virulence factors of Porphyromonas gingivalis on wound healing in vitro

Journal of Oral Microbiology, 2015
Background: Porphyromonas gingivalis inhibits oral epithelial wound healing in vitro more strongly than other oral bacteria, but it is unknown why P. gingivalis is such a potent inhibitor of wound healing.
Alexa M. G. A. Laheij, Cor van Loveren, Dongmei Deng, Johannes J. de Soet   +3 more
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Outer membrane vesicles of the oral pathogen Porphyromonas gingivalis promote aggregation and phagocytosis of Staphylococcus aureus

Frontiers in Oral Health, 2022
Staphylococcus aureus is an opportunistic Gram-positive bacterial pathogen that causes a wide variety of infectious diseases, including S. aureus bacteremia (SAB).
Marines du Teil Espina, Anna Haider Rubio, Yanyan Fu, Marina López-Álvarez, Giorgio Gabarrini, Jan Maarten van Dijl   +5 more
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Porphyromonas gingivalis suppresses invasion of Fusobacterium nucleatum into gingival epithelial cells

Journal of Oral Microbiology, 2017
Invasion of periodontal pathogens into periodontal tissues is an important step that can cause tissue destruction in periodontal diseases. Porphyromonas gingivalis is a keystone pathogen and its gingipains are key virulence factors.
Young-Jung Jung, Hye-Kyoung Jun, Bong-Kyu Choi   +2 more
doaj   +1 more source

Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits.

PLoS Pathogens, 2019
Neutrophil-derived networks of DNA-composed extracellular fibers covered with antimicrobial molecules, referred to as neutrophil extracellular traps (NETs), are recognized as a physiological microbicidal mechanism of innate immunity.
Danuta Bryzek, Izabela Ciaston, Ewelina Dobosz, Anna Gasiorek, Anna Makarska, Michal Sarna, Sigrun Eick, Magdalena Puklo, Maciej Lech, Barbara Potempa, Jan Potempa, Joanna Koziel   +11 more
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Characterization of Human Genes Modulated by Porphyromonas gingivalis Highlights the Ribosome, Hypothalamus, and Cholinergic Neurons

Frontiers in Immunology, 2021
Porphyromonas gingivalis, a bacterium associated with periodontal disease, is a suspected cause of Alzheimer’s disease. This bacterium is reliant on gingipain proteases, which cleave host proteins after arginine and lysine residues.
Sejal Patel, Derek Howard, Nityananda Chowdhury, Casey Derieux, Bridgette Wellslager, Özlem Yilmaz, Özlem Yilmaz, Leon French, Leon French, Leon French, Leon French   +10 more
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Porphyromonas gingivalis affects neutrophil pro-inflammatory activities

Frontiers in Cell and Developmental Biology
Porphyromonas gingivalis is the primary pathogen responsible for the development of periodontal inflammatory disease. Although gingipains are the major virulence factor of the pathogen, their role in impairing apoptosis and immune cell function is not ...
Agnieszka Zimny, Alicja Płonczyńska, Alicja Płonczyńska, Wiktor Jakubowski, Natalia Zubrzycka, Natalia Zubrzycka, Jan Potempa, Jan Potempa, Maja Sochalska   +8 more
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Porphyromonas gingivalis Gingipains Destroy the Vascular Barrier and Reduce CD99 and CD99L2 Expression To Regulate Transendothelial Migration

Microbiology Spectrum, 2023
Porphyromonas gingivalis is an important periodontal pathogen that can cause vascular injury and invade local tissues through the blood circulation, and its ability to evade leukocyte killing is critical to its distal colonization and survival ...
Zhaolei Zou, Juan Fang, Wanting Ma, Junyi Guo, Zhongyan Shan, Da Ma, Qiannan Hu, Liling Wen, Zhi Wang   +8 more
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Porphyromonas gingivalis Infection Induces Lipopolysaccharide and Peptidoglycan Penetration Through Gingival Epithelium

Frontiers in Oral Health, 2022
Periodontal diseases initiate on epithelial surfaces of the subgingival compartment, while the gingival epithelium functions as an epithelial barrier against microbial infection and orchestrates immune responses.
Hiroki Takeuchi, Eriko Nakamura, Shunsuke Yamaga, Atsuo Amano   +3 more
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Purified gingipains promote NET generation.

, 2019
(A) The level of NETs induced by gingipain cocktails containing each enzyme at 10 or 50 nM after 1 or 4 h of incubation, as determined by QPG. (B) Isolated neutrophils were stimulated with different gingipains (RgpA, RgpB, or Kgp; 50 nM), LPS and FimA ...
Maciej Lech (350641), Michal Sarna (697705), Barbara Potempa (6714821), Izabela Ciaston (6714806), Magdalena Puklo (6714818), Ewelina Dobosz (6714809), Anna Makarska (6714815), Danuta Bryzek (6714803), Anna Gasiorek (6714812), Jan Potempa (19854), Sigrun Eick (326398), Joanna Koziel (83263)   +11 more
core   +1 more source