Results 41 to 50 of about 24,766 (261)

Interface Wettability Transition‐Driven Drug Release and Dual‐Phase Functionalization in Implant Abutment

Advanced Science, EarlyView.
A temporally controlled drug release coating is developed for abutments using a superhydrophobic coating self‐assembled on mesoporous silica. This surface provides sequential functionality: initial contamination resistance through non‐wetting, followed by controlled drug release via wettability transition.
Zhongchao Wang, Liang Shi, MingXia Li, Xiao Han, Jinghan Wang, Guangping Wang, Dan Zou, Bingyang Lu, Liyuan Fan   +8 more
wiley   +1 more source

Porphyromonas gingivalis Gingipain-Dependently Enhances IL-33 Production in Human Gingival Epithelial Cells. [PDF]

PLoS ONE, 2016
The cytokine IL-33 is constitutively expressed in epithelial cells and it augments Th2 cytokine-mediated inflammatory responses by regulating innate immune cells.
Hiroyuki Tada, Takashi Matsuyama, Takashi Nishioka, Makoto Hagiwara, Yusuke Kiyoura, Hidetoshi Shimauchi, Kenji Matsushita   +6 more
doaj   +1 more source

Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses

Frontiers in Cellular and Infection Microbiology, 2023
Porphyromonas gingivalis (P. gingivalis) is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis. P. gingivalis expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing P.
Shuxian Jia, Shuxian Jia, Xiaobing Li, Xiaobing Li, Qin Du   +4 more
doaj   +1 more source

P. gingivalis Modulates Keratinocytes through FOXO Transcription Factors

PLoS ONE, 2013
P. gingivalis is a prominent periodontal pathogen that has potent effects on host cells. In this study we challenged gingival epithelial cells with P. gingivalis with the aim of assessing how mRNA levels of key target genes were modulated by P. gingivalis via the transcription factors FOXO1 and FOXO3.
Li, Shuai, Dong, Guangyu, Moschidis, Anastasios, Ortiz, Javier, Kinane, Denis F, Benakanakere, Manjunatha R, Graves, Dana T   +6 more
openaire   +5 more sources

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source

Porphyromonas gingivalis outer membrane vesicles augments proliferation and metastasis of oral squamous cell carcinoma cells

BMC Oral Health
Background Porphyromonas gingivalis (P. gingivalis) is closely related to Oral squamous cell carcinoma (OSCC), and P. gingivalis outer membrane vesicles (OMVs) is the main pathogenic factor, which is associated with periodontitis, atherosclerosis and ...
Yanru Zeng, Yiyang Wang, Xiaona Shi, Yuanhao Zhao, Yue Tang, Shanshan Liu, Xiaofeng Zhu   +6 more
doaj   +1 more source

A Blood‐Derived Double‐Network Hydrogel with Robust Wet Adhesion for Keratinized Mucosa Regeneration via Neutrophil Phenotype Reprogramming and Mechanophysical Niche Modulation

Advanced Science, EarlyView.
The iPRF‐MA/Alg‐NHS/Lut@EGCG (PGAE) double‐network hydrogel achieves durable wet adhesion in the oral environment. It simultaneously reprograms neutrophils from NETosis to phagocytosis for biofilm clearance, and activates the FAK‐RhoA‐YAP mechanotransduction pathway in gingival fibroblasts to drive extracellular matrix remodeling, thereby promoting ...
Sicong Ren, Xinting Yang, Jingxia Chen, Yihan Wang, Jian Feng, Jing Zhou, Jiaxin Luo, Jingjie Zhai, Quan Lin, Yanmin Zhou   +9 more
wiley   +1 more source

ASSOCIATION OF PORPHYROMONUS GINGIVALIS WITH RHEUMATOID ARTHRITIS

The Iraqi Journal of Medical Sciences, 2017
Background:Rheumatoid arthritis (RA) is chronic systemic inflammatory disease. Porphyromonus gingivalis (P. gingivalis) produce peptidyle arginine enzymes, which lead to citrullination of human protein then lead to formation anticitrullinated peptide ...
Sadeq k. Hachim, Ahmed A. Abbas, Mohammed H. Alosami   +2 more
doaj   +6 more sources

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

MiR‐146a‐5p Suppresses M1 Polarization of Tumor‐Associated Macrophages via IRAK1/NF‐κB Signaling in Colorectal Polyps

Annals of Gastroenterological Surgery, EarlyView.
MiR‐146a‐5p is downregulated in colorectal polyps, leading to IRAK1 upregulation and NF‐κB activation, which promotes M1 macrophage polarization and inflammation. Overexpression of miR‐146a‐5p suppresses IRAK1/NF‐κB signaling, reduces M1 polarization, and alleviates inflammatory responses.
Peng Song, Lianhui Wu, Huabin Qiu, Lei Luo, Jianzhao Qiu, Shuping Xiao, Jincai He   +6 more
wiley   +1 more source