Results 21 to 30 of about 20,775,577 (293)

A Novel Kinase Function of a Nucleoside-diphosphate-kinase Homolog in P. gingivalis is Critical in Subversion of Host Cell Apoptosis by Targeting Heat-Shock Protein 27

Cellular Microbiology, 2018
We have previously shown that a homologue of a conserved nucleoside‐diphosphate‐kinase (Ndk) family of multifunctional enzymes and secreted molecule in Porphyromonas gingivalis can modulate select host molecular pathways including downregulation of ...
Jungnam Lee, JoAnn S. Roberts, K. Atanasova, N. Chowdhury, Ö. Yilmaz   +4 more
semanticscholar   +1 more source

Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver

PLoS ONE, 2015
Although periodontitis has been implicated as a risk factor for various systemic diseases, the precise mechanisms by which periodontitis induces systemic disease remain to be elucidated.
Mayuka Nakajima, Kei Arimatsu, Tamotsu Kato, Y. Matsuda, T. Minagawa, N. Takahashi, H. Ohno, K. Yamazaki   +7 more
semanticscholar   +1 more source

Soluble CD14 Enhances the Response of Periodontal Ligament Stem Cells to P. gingivalis Lipopolysaccharide

PLoS ONE, 2016
Periodontal ligament stem cells (PDLSCs) are lacking membrane CD14, which is an important component of lipopolysaccharide (LPS) signaling through toll-like receptor (TLR) 4.
O. Andrukhov, O. Andrukhova, B. Özdemir, H. Haririan, Michael Müller-Kern, A. Moritz, X. Rausch-Fan   +6 more
semanticscholar   +1 more source

Roles of Oral Bacteria in Cardiovascular Diseases — From Molecular Mechanisms to Clinical Cases: Involvement of Porphyromonas gingivalis in the Development of Human Aortic Aneurysm

Journal of Pharmacological Sciences, 2010
Accumulating evidence suggests the involvement of Porphyromonas gingivalis (P. gingivalis), a periodontal pathogen, in cardiovascular diseases. Clinical specimens of aneurysmal tissue and dental plaque collected from patients infected with or without P ...
Koichiro Wada, Yoshinori Kamisaki
doaj   +1 more source

Hypoxia and P. gingivalis Synergistically Induce HIF-1 and NF-κB Activation in PDL Cells and Periodontal Diseases

Mediators of Inflammation, 2015
Periodontitis is characterized by deep periodontal pockets favoring the proliferation of anaerobic bacteria like Porphyromonas gingivalis (P. gingivalis), a periodontal pathogen frequently observed in patients suffering from periodontal inflammation ...
L. Gölz, S. Memmert, B. Rath-Deschner, A. Jäger, T. Appel, G. Baumgarten, W. Götz, S. Frede   +7 more
semanticscholar   +1 more source

Intracellular Porphyromonas gingivalis Promotes the Proliferation of Colorectal Cancer Cells via the MAPK/ERK Signaling Pathway

Frontiers in Cellular and Infection Microbiology, 2020
Porphyromonas gingivalis (P. gingivalis) is a keystone pathogen in periodontitis. However, several clinical studies have revealed an enrichment of P. gingivalis in the stool samples and colorectal mucosa of colorectal cancer patients.
Wenxin Mu, Yiqun Jia, Xiaobing Chen, Haoyu Li, Zhi Wang, Bin Cheng   +5 more
doaj   +1 more source

P. gingivalis in Periodontal Disease and Atherosclerosis – Scenes of Action for Antimicrobial Peptides and Complement

Frontiers in Immunology, 2015
According to the NHS, it is estimated that over 50% of the adult population are, to some extent, affected by gum disease and approximately 15% of UK population have been diagnosed with severe periodontitis.
M. Hussain, C. Stover, A. Dupont
semanticscholar   +1 more source

Antimicrobial and anti-inflammatory activity of Cystatin C on human gingival fibroblast incubated with Porphyromonas gingivalis [PDF]

PeerJ, 2022
Background Periodontal disease is considered one of the most prevalent chronic infectious diseases, often leading to the disruption of tooth-supporting tissues, including alveolar bone, causing tooth mobility and loss.
Blanca Esther Blancas-Luciano, Ingeborg Becker-Fauser, Jaime Zamora-Chimal, José Delgado-Domínguez, Adriana Ruíz-Remigio, Elba Rosa Leyva-Huerta, Javier Portilla-Robertson, Ana María Fernández-Presas   +7 more
doaj   +2 more sources

Different effects of P. gingivalis LPS and E. coli LPS on the expression of interleukin-6 in human gingival fibroblasts

Acta Odontologica Scandinavica, 2014
Objective. Gingival fibroblasts (GFs) produce pro-inflammatory cytokines in response to stimulation with lipopolysaccharide (LPS) of Porphyromonas gingivalis, which is thought to be mediated by activation of toll-like receptors (TLR)2 and TLR4.
O. Andrukhov, Sandra Ertlschweiger, A. Moritz, H. Bantleon, X. Rausch-Fan   +4 more
semanticscholar   +1 more source

Porphyromonas gingivalis sphingolipids affect early responses of THP-1 macrophages to outer membrane vesicles

Infection and Immunity
Porphyromonas gingivalis is an oral bacterium commonly associated with periodontitis. P. gingivalis synthesizes sphingolipids (SLs), and recently, we reported that P.
Zavier G. Eure, Tamires Fernanda Vilas Boas Cordeiro, Alejandro Riveros Walker, Fernanda G. Rocha, Mary Ellen Davey, Frank C. Gibson   +5 more
doaj   +1 more source