Results 71 to 80 of about 22,090 (275)

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene. [PDF]

, 2009
Hedgehog signaling is often activated in tumors, yet it remains unclear how GLI2, a transcription factor activated by this pathway, acts as an oncogene. We show that GLI2 is a pleiotropic oncogene.
Albertson, DG, Connelly, ST, Huey, B, Jordan, RCK, Roy, R, Schmidt, BL, Snijders, AM   +6 more
core  

Pluronic F-127 hydrogel as a promising scaffold for encapsulation of dental-derived mesenchymal stem cells. [PDF]

, 2015
Dental-derived mesenchymal stem cells (MSCs) provide an advantageous therapeutic option for tissue engineering due to their high accessibility and bioavailability.
Ansari, Sahar, Chen, Chider, Diniz, Ivana MA, Marques, Márcia M, Moshaverinia, Alireza, Shi, Songtao, Xu, Xingtian, Zadeh, Homayoun H   +7 more
core   +1 more source

Oral Motion‐Powered Smart Dental Implant Abutment for In Situ Antibacterial and Cell Adhesion Through Piezoelectric Effect

Advanced Science, EarlyView.
We proposed a method based on the piezoelectric effect and fabricated an implant abutment on the basis of piezoelectric ceramic. Under physiological occlusal pressure, the oral motion‐powered smart dental implant abutments interacted with water and oxygen, promoting the formation of reactive oxygen species and achieving a synergistic and highly ...
Xiyu Shi, Xiaoyu Han, Yanhui Lu, Yuan Chai, Baiyan Xiao, Shuo Liu, Boon Chin Heng, Tingting Wu, Tingjun Li, Qiaomei Ren, Ting Song, Le Chen, Dong Han, Yaru Guo, Xuliang Deng, Xuehui Zhang   +15 more
wiley   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Comparison of gingival and periodontal phenotype classification methods and phenotype-related clinical parameters: cross-sectional observational study

BMC Oral Health
Background The aim of this study was to assess gingival and periodontal-phenotype by using Standard-Periodontal-Probing (SPP), Colored-Periodontal-Probing (CPP), and Cone-Beam-Computed-Tomography (CBCT) in comparison to gold standard transgingival ...
Dila İrem Aşkın, Mahmure Ayşe Tayman, Berrin Çelik, Kıvanç Kamburoğlu, Doğukan Özen   +4 more
doaj   +1 more source

Diabetes and periodontitis [PDF]

, 2004
Copyright © 2004 Australian Prescriber Reproduced with permission from Australian Prescriber The document attached has been archived with permission from the publisher/copyright holder.Chronic gingivitis and periodontitis are common inflammatory ...
Hirsch, R.
core   +2 more sources

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

Correlation of Periodontal Phenotype with Periodontal Probing Depth in Maxillary Anterior Teeth: A Cross-Sectional Study Using Probe Transparency Method

Journal of Aziz Fatimah Medical and Dental College
Obejective: To correlate periodontal phenotype with periodontal probing depth in maxillary anterior teeth in patients reporting to a tertiary care dental hospital for their routine periodontal care using probe transparency method Methodology: In this ...
Maha Maqool, Usman Manzoor, Sadia Iqbal, Sittara Javed, Hania Ali, Zubair Ahmed Khan   +5 more
doaj   +1 more source

Positional stability of the periodontal tissues following crown lengthening surgery

Dentistry Review, 2022
Objectives: Functional and esthetic crown lengthening surgery (CLS) is one of the most common surgical procedures in periodontal practice. The healing time necessary to achieve stable periodontal tissues, including the supracrestal gingival tissue (SGT ...
Walid Altayeb, Roberto Rossi, Josep Arnabat-Dominguez   +2 more
doaj   +1 more source