Results 161 to 170 of about 4,987 (188)

Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS

Biochemical and Biophysical Research Communications, 2015
Ginsenoside Rg3, a specific biological effector, is well-known as a major bioactive ingredient of Panax ginseng. However, its role in the inflammasome activation process remains unclear. In this report, we demonstrate that ginsenosides 20(R)-Rg3 and 20(S)
Sung-Jin Yoon, Jun-Young Park, Haiyoung Jung   +2 more
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Microbial transformation of ginsenoside Rg3 to ginsenoside Rh2 by Esteya vermicola CNU 120806

World Journal of Microbiology and Biotechnology, 2011
In the present investigation, we successfully employed a cell-free extract of Esteya vermicola CNU 120806 to convert ginsenoside Rg3 to Rh2. Three important factors including pH, temperature and substrate concentration were optimized for the preparation of Rh(2). The optimal condition was obtained as follows: 50°C, pH 5.0 and substrate concentration of
Jingang, Hou, Jianjie, Xue, Chunyan, Wang, Lei, Liu, Dongliang, Zhang, Zhen, Wang, Wei, Li, Yinan, Zheng, Changkeun, Sung   +8 more
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Synthesis of ginsenoside Rg3, a minor constituent of Ginseng Radix

Carbohydrate Research, 1997
Glycosylation of 12beta-acetoxy-dammar-24-en-3beta,20(S)-diol (4), with hepta-O-acetyl-alpha-sophorosyl bromide (5) under catalysis by Ag2CO3 or Ag2O afforded a chromatographically unseparated mixture of the alpha- and beta-linked octaacetates 6 and 7 in an approximately 2.5:1 ratio. After deprotection and chromatographic purification, the free alpha- (
V P, Anufriev, G V, Malinovskaya, V A, Denisenko, N I, Uvaròva, G B, Elyakov, S I, Kim, N I, Baek   +6 more
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Protective effects of ginsenoside Rg3 on human osteoarthritic chondrocytes

Modern Rheumatology, 2012
To explore whether Rg3, a major and especially potent ginsenoside, modulates human osteoarthritic (OA) chondrocyte senescence.Isolated chondrocytes were cultured in medium containing interleukin-1 beta (IL-1β) with or without Rg3. The expression levels of mRNAs encoding aggrecan (ACAN), a major structural proteoglycan, type II collagen (COL2A1), and ...
Min Wook, So, Eun-Ju, Lee, Han Sang, Lee, Bon San, Koo, Yong-Gil, Kim, Chang-Keun, Lee, Bin, Yoo   +6 more
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In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3

Journal of Chromatography B, 2005
Metabolism of an anti-tumor active component of Panax ginseng, ginsenoside (20R)-Rg(3), was studied for better understanding its pharmacokinetics in rat. LC-MS was used to determine Rg(3) and its metabolites in rat plasma, urine and feces samples. An average half-life of 18.5 min was obtained after the ginsenoside was intravenously dosed at 5 mg/kg ...
Tianxiu, Qian, Zongwei, Cai, Ricky N S, Wong, Nai Ki, Mak, Zhi-Hong, Jiang   +4 more
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Ginsenoside Rb1 and Rg3 Attenuate Glucocorticoid-Induced Neurotoxicity

Cellular and Molecular Neurobiology, 2010
Glucocorticoid (GC) hormones, increased in response to stress, can cause neuronal loss. We tested the effect of GC hormone on cell viability of neural SHSY-5Y cells and protective effects of ginsenoside Rb1 and Rg3 on the action of GC. We treated SHSY-5Y cells with increasing concentrations of synthetic GC dexamethasone (DEX; 10, 25, 50, and 100 nM ...
Sung-Ok, Kim, Jung-Man, You, Su-Jin, Yun, Min-Sook, Son, Kyong Nyon, Nam, Joung-Woo, Hong, Sun Yeou, Kim, Sang Yoon, Choi, Eunjoo H, Lee   +8 more
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Antinociceptive Effects of Ginsenoside Rg3 in a Rat Model of Incisional Pain

European Surgical Research, 2016
<b><i>Background:</i></b> Ginsenoside Rg3 is an extract of total ginseng saponins, which accounts for 4.7% of all saponins. This study aimed to identify the mechanisms of the antinociceptive effects of ginsenoside Rg3. <b><i>Methods:</i></b> Rats were randomly divided into six groups, which were treated ...
Eun Jin, Ahn, Geun Joo, Choi, Hyun, Kang, Chong Wha, Baek, Yong Hun, Jung, Young Cheol, Woo, Si Ra, Bang   +6 more
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[Fungal biotransformation of ginsenoside Rg3].

Wei sheng wu xue bao = Acta microbiologica Sinica, 2009
Ginsenosides are important bioactive compounds in Ginseng. Sugar chains of ginsenosides are closely related to the bioactivity. Rare ginsenosides can be achieved by modifying sugar chains through biotransformation. Samples of Ginseng root soils, collected from Changbai Mountain, were used to screen active microorganism which can transform total ...
Wu, Xiuli, Wang, Yan, Zhao, Wenqian, Zhang, Yixuan   +3 more
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Protective effect of ginsenoside Rg3 on lung injury in diabetic rats

Journal of Cellular Biochemistry, 2018
AbstractGinsenoside has been used to treat diabetes, while ginsenoside Rg3 is the main active ingredient component of ginseng and is used to study its effects on lung tissue damage in diabetic rats. In this paper, 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay and flow cytometry were applied to detect the proliferation and apoptosis
Heyuan Wang, Wei Wu, Guixia Wang, Wenzhou Xu, Fuqiang Zhang, Bing Wu, Yaping Tian   +6 more
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Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts

Metabolic Engineering, 2015
Ginsenosides Rh2 and Rg3 represent promising candidates for cancer prevention and therapy and have low toxicity. However, the concentrations of Rh2 and Rg3 are extremely low in the bioactive constituents (triterpene saponins) of ginseng. Despite the available heterologous biosynthesis of their aglycone (protopanaxadiol, PPD) in yeast, production of Rh2
Pingping, Wang, Yongjun, Wei, Yun, Fan, Qunfang, Liu, Wei, Wei, Chengshuai, Yang, Lei, Zhang, Guoping, Zhao, Jianmin, Yue, Xing, Yan, Zhihua, Zhou   +10 more
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