A brief method for preparation of gintonin-enriched fraction from ginseng [PDF]
Journal of Ginseng Research, 2015 Background: Ginseng has been used as a tonic for invigoration of the human body. In a previous report, we identified a novel candidate responsible for the tonic role of ginseng, designated gintonin.
Sun-Hye Choi +10 more
doaj +8 more sources
Safety and efficacy of dietary supplement (gintonin-enriched fraction from ginseng) in subjective memory impairment: A randomized placebo-controlled trial [PDF]
Integrative Medicine Research, 2022 Background: Gintonin inhibits β-amyloid production, increases acetylcholine level in the brain, and promotes neurogenesis. We evaluated the efficacy of gintonin-enriched fraction (GEF) in improving the cognitive performance in subjective memory ...
Woo-Jin Lee +7 more
doaj +6 more sources
A novel protocol for batch-separating gintonin-enriched, polysaccharide-enriched, and crude ginsenoside-containing fractions from Panax ginseng [PDF]
Journal of Ginseng Research, 2023 Background: Ginseng contains three active components: ginsenosides, gintonin, and polysaccharides. After the separation of 1 of the 3 ingredient fractions, other fractions are usually discarded as waste. In this study, we developed a simple and effective
Rami Lee +11 more
doaj +6 more sources
Effects of Gintonin-Enriched Fraction on Methylmercury-Induced Neurotoxicity and Organ Methylmercury Elimination [PDF]
International Journal of Environmental Research and Public Health, 2020 Gintonin is a newly discovered ingredient of ginseng and plays an exogenous ligand for G protein-coupled lysophosphatidic acid receptors. We previously showed that gintonin exhibits diverse effects from neurotransmitter release to improvement of Alzheimer’s disease-related cognitive dysfunctions.
Seung-Yeol Nah +2 more
exaly +7 more sources
Gintonin-Enriched Panax ginseng Extract Fraction Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis through DR4/5 Upregulation [PDF]
Current Issues in Molecular BiologyTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising chemotherapeutic agent because of its selective apoptotic action on cancer cells. However, resistance to TRAIL-induced apoptosis remains a challenge in many cancers.
Seongwoo Hong +7 more
doaj +5 more sources
Potential Anti-Inflammatory Effects of Gintonin-Enriched Fraction in TNF-α-Stimulated Keratinocytes [PDF]
International Journal of Molecular SciencesGintonin-enriched fraction (GEF), a bioactive glycolipoprotein derived from Panax ginseng is known for its potential as a natural anti-inflammatory agent. Keratinocytes are closely related to the development and progression of various inflammatory skin conditions.
Lee R +5 more
exaly +4 more sources
Ginseng gintonin, aging societies, and geriatric brain diseases [PDF]
Integrative Medicine Research, 2021 Background: A dramatic increase in aging populations and low birth rates rapidly drive aging societies and increase aging-associated neurodegenerative diseases.
Sun-Hye Choi +8 more
doaj +2 more sources
Gintonin as a Lysophosphatidic Acid-Enriched GPCR Ligand System: Molecular Architecture and Receptor Pharmacology in Panax ginseng [PDF]
BiomoleculesFor decades, the pharmacological identity of Panax ginseng has been primarily attributed to triterpenoid saponins known as ginsenosides. However, accumulating evidence indicates that ginseng also contains a structurally distinct lipid–protein complex ...
Kyung-Hee Kim, Byong Chul Yoo
doaj +2 more sources
Gintonin-Enriched Panax ginseng Extract Induces Apoptosis in Human Melanoma Cells by Causing Cell Cycle Arrest and Activating Caspases [PDF]
FoodsGintonin, a non-saponin glycolipoprotein from Panax ginseng, acts as a lysophosphatidic acid ligand. However, its anticancer effects, especially in melanoma, remain unclear.
Su-Hyun Lee +8 more
doaj +2 more sources
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 Pyocyanin (PCN) is a redox‐active secondary metabolite produced by Pseudomonas aeruginosa as its primary virulence factor. Several studies have reported the cytotoxic potential of PCN and its role during infection establishment and progression. Considering its ability to diffuse through biological membranes, it is hypothesized that PCN can gain entry ...
Muhammad Ibrahim Rashid +4 more
wiley +1 more source