Visualization of the binding between gintonin, a Panax ginseng-derived LPA receptor ligand, and the LPA receptor subtypes and transactivation of the EGF receptor [PDF]
Journal of Ginseng Research, 2022 Background: Gintonin is a ginseng-derived exogenous G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. Gintonin exerts its neuronal and non-neuronal in vitro and in vivo effects through LPA receptor subtypes.
Seung-Yeol Nah +2 more
exaly +4 more sources
Gintonin Stimulates Glucose Uptake in Myocytes: Involvement of Calcium and Extracellular Signal-Regulated Kinase Signaling [PDF]
BiomoleculesGinseng has anti-hyperglycemic effects. Gintonin, a glycolipoprotein derived from ginseng, also stimulates insulin release from pancreatic beta cells. However, the role of gintonin in glucose metabolism within skeletal muscle is unknown.
Kyung Jong Won +2 more
exaly +4 more sources
Gintonin stimulates dendritic growth in striatal neurons by activating Akt and CREB [PDF]
Frontiers in Molecular Neuroscience, 2022 Gintonin, a glycolipid protein conjugated with lysophosphatidic acid (LPA), is a newly identified compound extracted from Korean ginseng. LPA receptor isotypes exhibit high affinity for gintonin and mediate intracellular calcium signaling in various ...
Hye Kyung Lim +5 more
doaj +2 more sources
Gintonin influences the morphology and motility of adult brain neurons via LPA receptors
Journal of Ginseng Research, 2021 Background: Gintonin is an exogenous ginseng-derived G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. LPA induces in vitro morphological changes and migration through neuronal LPA1 receptor.
Seung-Yeol Nah +2 more
exaly +3 more sources
Journal of Ginseng Research, 2021 Background: Gintonin is a ginseng-derived exogenous G-protein–coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors.
Seung-Yeol Nah +2 more
exaly +3 more sources
Gintonin Binds to Reduced LPA4 Receptor Subtype in Human Cortical Neurons in Alzheimer’s Disease Brains [PDF]
BiomoleculesGinseng, a traditional herbal medicine with a long history of use, is known to support human health, particularly by influencing brain function. Recent studies have identified gintonin, a lysophosphatidic acid (LPA) receptor ligand derived from ginseng ...
Kyu-Sung Kim +13 more
doaj +2 more sources
Gintonin as a Lysophosphatidic Acid-Enriched GPCR Ligand System: Molecular Architecture and Receptor Pharmacology in Panax ginseng [PDF]
BiomoleculesFor decades, the pharmacological identity of Panax ginseng has been primarily attributed to triterpenoid saponins known as ginsenosides. However, accumulating evidence indicates that ginseng also contains a structurally distinct lipid–protein complex ...
Kyung-Hee Kim, Byong Chul Yoo
doaj +2 more sources
Gintonin absorption in intestinal model systems
Journal of Ginseng Research, 2018 Background: Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing ...
Seung-Yeol Nah +2 more
exaly +3 more sources
Protective Effects of Gintonin on Reactive Oxygen Species-Induced HT22 Cell Damages: Involvement of LPA1 Receptor-BDNF-AKT Signaling Pathway [PDF]
Molecules, 2021 Gintonin is a kind of ginseng-derived glycolipoprotein that acts as an exogenous LPA receptor ligand. Gintonin has in vitro and in vivo neuroprotective effects; however, little is known about the cellular mechanisms underlying the neuroprotection. In the
Yeon-Jin Cho +8 more
doaj +2 more sources
Study on the Therapeutic Effects and Mechanisms of Gintonin in Irritable Bowel Syndrome and Its Relationship with TRPV1, TRPV4, and NaV1.5 [PDF]
PharmaceuticalsIrritable bowel syndrome (IBS) is a gastrointestinal (GI) disease accompanied by changes in bowel habits without any specific cause. Gintonin is a newly isolated glycoprotein from ginseng that is a lysophosphatidic acid (LPA) receptor ligand.
Na-Ri Choi +7 more
doaj +2 more sources