Ginseng Gintonin Contains Ligands for GPR40 and GPR55 [PDF]
Molecules, 2020 Gintonin, a novel ginseng-derived glycolipoprotein complex, has an exogenous ligand for lysophosphatidic acid (LPA) receptors. However, recent lipid analysis of gintonin has shown that gintonin also contains other bioactive lipids besides LPAs, including
Seung-Yeol Nah, Rami Lee, Ik Hyun Cho
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Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2 [PDF]
Journal of Ginseng Research, 2021 Background: In ginseng, there exists a glycolipoprotein complex with a special form of lipid LPAs called Gintonin. The purpose of this study is to show that Gintonin has a therapeutic effect on rheumatoid arthritis through LPA2 receptors.
Seikwan Oh, Jaesuk Yun, Thea Villa
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Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders [PDF]
Cells, 2020 Neurodegenerative disorders, namely Parkinson’s disease (PD), Huntington’s disease (HD), Alzheimer’s disease (AD), and multiple sclerosis (MS), are increasingly major health concerns due to the increasingly aged population worldwide.
Muhammad Ikram +2 more
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Gintonin-mediated release of astrocytic vascular endothelial growth factor protects cortical astrocytes from hypoxia-induced cell damages [PDF]
Journal of Ginseng Research, 2019 Background: Gintonin is a ginseng-derived exogenous ligand of the G protein-coupled lysophosphatidic acid (LPA) receptor. We previously reported that gintonin stimulates gliotransmitter release in primary cortical astrocytes. Astrocytes play key roles in
Seung-Yeol Nah +2 more
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Gintonin Isolated from Ginseng Inhibits the Epithelial—Mesenchymal Transition Induced by TGF-β in A549 Lung Cancer Cells [PDF]
Plants, 2023 Epithelial-to-mesenchymal transition (EM transition) is a process wherein epithelial cells lose their intrinsic characteristics and cell–cell junctions and differentiate into a mesenchymal phenotype.
Sung Jin Kim +4 more
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Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release [PDF]
Molecules, 2021 Ginseng-derived gintonin reportedly contains functional lysophosphatidic acids (LPAs) as LPA receptor ligands. The effect of the gintonin-enriched fraction (GEF) on in vitro and in vivo glucagon-like protein-1 (GLP-1) secretion, which is known to ...
Rami Lee +7 more
doaj +4 more sources
Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient [PDF]
Nutrients, 2023 Ginseng is one of the traditional herbal medicines for tonic. Gintonin is a new material derived from white/red ginseng and its lysophosphatidic acids (LPAs) play as a ligand for G protein-coupled LPA receptors.
Seung-Yeol Nah, Rami Lee, Ik Hyun Cho
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Gintonin-Enriched Fraction Suppresses Heat Stress-Induced Inflammation through LPA Receptor [PDF]
Molecules, 2020 Heat stress can be caused by various environmental factors. When exposed to heat stress, oxidative stress and inflammatory reaction occur due to an increase of reactive oxygen species (ROS) in the body.
Seung-Yeol Nah +2 more
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Bioactive lipids in gintonin-enriched fraction from ginseng [PDF]
Journal of Ginseng Research, 2019 Background: Ginseng is a traditional herbal medicine for human health. Ginseng contains a bioactive ligand named gintonin. The active ingredient of gintonin is lysophosphatidic acid C18:2 (LPA C18:2).
Seung-Yeol Nah +2 more
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Gintonin-Induced Wound-Healing-Related Responses Involve Epidermal-Growth-Factor-like Effects in Keratinocytes [PDF]
International Journal of Molecular Sciences, 2023 Epidermal growth factor (EGF) receptor activation and related downstream signaling pathways are known to be one of the major mechanisms of the proliferation and migration of keratinocytes.
Kyung Jong Won +2 more
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