Effects of gintonin on the proliferation, migration, and tube formation of human umbilical-vein endothelial cells: involvement of lysophosphatidic-acid receptors and vascular-endothelial-growth-factor signaling [PDF]
Journal of Ginseng Research, 2016 Background: Ginseng extracts are known to have angiogenic effects. However, to date, only limited information is available on the molecular mechanism underlying the angiogenic effects and the main components of ginseng that exert these effects.
Sung-Hee Hwang +8 more
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Gintonin-Enriched Panax ginseng Extract Induces Apoptosis in Human Melanoma Cells by Causing Cell Cycle Arrest and Activating Caspases [PDF]
FoodsGintonin, a non-saponin glycolipoprotein from Panax ginseng, acts as a lysophosphatidic acid ligand. However, its anticancer effects, especially in melanoma, remain unclear.
Su-Hyun Lee +8 more
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Gintonin Enhances Proliferation, Late Stage Differentiation, and Cell Survival From Endoplasmic Reticulum Stress of Oligodendrocyte Lineage Cells [PDF]
Frontiers in Pharmacology, 2019 Although evidence on myelin diseases is steadily accumulating, effective preventive or therapeutic strategies against them have not been established so far.
Mohammad Al Mijan +8 more
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Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study [PDF]
Journal of Ginseng Research, 2020 Background: Ginseng has been widely used as a health-promoting tonic. Gintonin present in ginseng acts as a lysophosphatidic acid (LPA) receptor ligand that activates six LPA receptor subtypes. The LPA6 subtype plays a key role in normal hair growth, and
Na-Eun Lee +11 more
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Effects of Gintonin-enriched fraction on the gene expression of six lysophosphatidic receptor subtypes [PDF]
Journal of Ginseng Research, 2021 Background: Gintonin, isolated from ginseng, acts as a ginseng-derived lysophosphatidic acid (LPA) receptor ligand and elicits the [Ca2+]i transient through six LPA receptor subtypes (LPARSs). However, the long-term effects of gintonin-enriched fraction (
Rami Lee +9 more
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Research progress on the mechanisms of Panax ginseng and its active components in maintaining skin homeostasis and disease intervention [PDF]
Chinese MedicinePanax ginseng (Panax ginseng C.A. Meyer) is a classic herbal medicine widely utilized in dermatological management, yet its precise therapeutic mechanisms have only recently begun to be fully elucidated.
Lu Ding +12 more
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Gintonin-Enriched Panax ginseng Extract Fraction Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis through DR4/5 Upregulation [PDF]
Current Issues in Molecular BiologyTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising chemotherapeutic agent because of its selective apoptotic action on cancer cells. However, resistance to TRAIL-induced apoptosis remains a challenge in many cancers.
Seongwoo Hong +7 more
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Gintonin stimulates autophagic flux in primary cortical astrocytes [PDF]
Journal of Ginseng Research, 2020 Background: Gintonin (GT), a novel ginseng-derived exogenous ligand of lysophosphatidic acid (LPA) receptors, has been shown to induce cell proliferation and migration in the hippocampus, regulate calcium-dependent ion channels in the astrocytes, and ...
Md. Ataur Rahman +3 more
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Panax ginseng as an adjuvant treatment for Alzheimer's disease [PDF]
Journal of Ginseng Research, 2018 Longevity in medicine can be defined as a long life without mental or physical deficits. This can be prevented by Alzheimer's disease (AD). Current conventional AD treatments only alleviate the symptoms without reversing AD progression.
Hyeon-Joong Kim +7 more
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Retracted: Oral Administration of Gintonin Protects the Brains of Mice against Aβ-Induced Alzheimer Disease Pathology: Antioxidant and Anti-Inflammatory Effects. [PDF]
Oxid Med Cell Longev, 2023 Oxidative Medicine and Cellular Longevity, Volume 2023, Issue 1, 2023.
Longevity OMAC.
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