A brief method for preparation of gintonin-enriched fraction from ginseng
Journal of Ginseng Research, 2015 Background: Ginseng has been used as a tonic for invigoration of the human body. In a previous report, we identified a novel candidate responsible for the tonic role of ginseng, designated gintonin.
Sun-Hye Choi +10 more
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Journal of Ginseng Research, 2021 Background: In ginseng, there exists a glycolipoprotein complex with a special form of lipid LPAs called Gintonin. The purpose of this study is to show that Gintonin has a therapeutic effect on rheumatoid arthritis through LPA2 receptors.
Thea Villa, Jaesuk Yun, Seung-Yeol Nah
exaly +3 more sources
Gintonin stimulates autophagic flux in primary cortical astrocytes
Journal of Ginseng Research, 2020 Background: Gintonin (GT), a novel ginseng-derived exogenous ligand of lysophosphatidic acid (LPA) receptors, has been shown to induce cell proliferation and migration in the hippocampus, regulate calcium-dependent ion channels in the astrocytes, and ...
Md. Ataur Rahman +3 more
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A novel protocol for batch-separating gintonin-enriched, polysaccharide-enriched, and crude ginsenoside-containing fractions from Panax ginseng [PDF]
Journal of Ginseng Research, 2023 Background: Ginseng contains three active components: ginsenosides, gintonin, and polysaccharides. After the separation of 1 of the 3 ingredient fractions, other fractions are usually discarded as waste. In this study, we developed a simple and effective
Rami Lee +11 more
doaj +2 more sources
The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases [PDF]
Frontiers in Aging, 2023 The pathophysiology of different neurodegenerative illnesses is significantly influenced by the polarization regulation of microglia and macrophages.
Samar F. Darwish +5 more
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Ginseng pharmacology: a new paradigm based on gintonin-lysophosphatidic acid receptor interactions [PDF]
Frontiers in Pharmacology, 2015 Ginseng, the root of Panax ginseng, is used as a traditional medicine. Despite the long history of the use of ginseng, there is no specific scientific or clinical rationale for ginseng pharmacology besides its application as a general tonic.
Seung-Yeol eNah +6 more
doaj +3 more sources
Gintonin-Enriched Panax ginseng Extract Induces Apoptosis in Human Melanoma Cells by Causing Cell Cycle Arrest and Activating Caspases [PDF]
FoodsGintonin, a non-saponin glycolipoprotein from Panax ginseng, acts as a lysophosphatidic acid ligand. However, its anticancer effects, especially in melanoma, remain unclear.
Su-Hyun Lee +8 more
doaj +2 more sources
Journal of Ginseng Research, 2019 Background: Gintonin is a ginseng-derived exogenous ligand of the G protein-coupled lysophosphatidic acid (LPA) receptor. We previously reported that gintonin stimulates gliotransmitter release in primary cortical astrocytes. Astrocytes play key roles in
Sun-Hye Choi +2 more
exaly +3 more sources
Safety and efficacy of dietary supplement (gintonin-enriched fraction from ginseng) in subjective memory impairment: A randomized placebo-controlled trial [PDF]
Integrative Medicine Research, 2022 Background: Gintonin inhibits β-amyloid production, increases acetylcholine level in the brain, and promotes neurogenesis. We evaluated the efficacy of gintonin-enriched fraction (GEF) in improving the cognitive performance in subjective memory ...
Woo-Jin Lee +7 more
doaj +2 more sources
Journal of Ginseng Research, 2021 Background: Gintonin, isolated from ginseng, acts as a ginseng-derived lysophosphatidic acid (LPA) receptor ligand and elicits the [Ca2+]i transient through six LPA receptor subtypes (LPARSs). However, the long-term effects of gintonin-enriched fraction (
Rami Lee +9 more
doaj +3 more sources