Gintonin Alleviates HCl/Ethanol- and Indomethacin-Induced Gastric Ulcers in Mice [PDF]
International Journal of Molecular Sciences, 2023 Gintonin, newly extracted from ginseng, is a glycoprotein that acts as an exogenous lysophosphatidic acid (LPA) receptor ligand. This study aimed to demonstrate the in vivo preventive effects of gintonin on gastric damage. ICR mice were randomly assigned
Seung-Yeol Nah, Rami Lee, Ik Hyun Cho
exaly +4 more sources
Ginseng Gintonin Attenuates Lead-Induced Rat Cerebellar Impairments during Gestation and Lactation [PDF]
Biomolecules, 2020 Gintonin, a novel ginseng-derived lysophosphatidic acid receptor ligand, improves brain functions and protects neurons from oxidative stress. However, little is known about the effects of gintonin against Pb-induced brain maldevelopment.
Sung Min Nam +7 more
doaj +2 more sources
Hippocampus-dependent cognitive enhancement induced by systemic gintonin administration [PDF]
Journal of Ginseng Research, 2016 Background: A number of neurological and neurodegenerative diseases share impaired cognition as a common symptom. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest.
Sungmin Kim +7 more
doaj +2 more sources
A brief method for preparation of gintonin-enriched fraction from ginseng [PDF]
Journal of Ginseng Research, 2015 Background: Ginseng has been used as a tonic for invigoration of the human body. In a previous report, we identified a novel candidate responsible for the tonic role of ginseng, designated gintonin.
Sun-Hye Choi +10 more
doaj +2 more sources
Multi-Target Protective Effects of Gintonin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Mediated Model of Parkinson’s Disease via Lysophosphatidic Acid Receptors [PDF]
Frontiers in Pharmacology, 2018 Gintonin is a ginseng-derived lysophosphatidic acid receptor (LPAR) ligand. Although previous in vitro and in vivo studies demonstrated the therapeutic role of gintonin against Alzheimer’s disease, the neuroprotective effects of gintonin in Parkinson’s ...
Jong Hee Choi +7 more
doaj +4 more sources
Characteristics of Gintonin-Mediated Membrane Depolarization of Pacemaker Activity in Cultured Interstitial Cells of Cajal [PDF]
Cellular Physiology and Biochemistry, 2014 Background/Aims: Ginseng regulates gastrointestinal (GI) motor activity but the underlying components and molecular mechanisms are unknown. We investigated the effect of gintonin, a novel ginseng-derived G protein-coupled lysophosphatidic acid (LPA ...
Byung Joo Kim +11 more
doaj +2 more sources
Cognitive function improvement effects of gintonin-enriched fraction in subjective memory impairment: An assessor- and participant-blinded placebo-controlled study [PDF]
Journal of Ginseng Research, 2023 Background: Gintonin is a new material of ginseng that acts through the ginseng-derived lysophosphatidic acid (LPA) receptor ligand. The gintonin-enriched fraction (GEF) inhibits amyloid plaque accumulation in the cortex and hippocampus, improves ...
Rami Lee +4 more
doaj +2 more sources
Ginseng Nanosizing: The Second Spring of Ginseng Therapeutic Applications [PDF]
AntioxidantsPlant-derived vesicles offer several advantages, including high yield, low cost, ethical compatibility, safety, and potential health benefits. These advantages enable them to overcome technological limitations associated with vesicles of mammalian origin.
Jian Wang +8 more
doaj +2 more sources
A novel protocol for batch-separating gintonin-enriched, polysaccharide-enriched, and crude ginsenoside-containing fractions from Panax ginseng [PDF]
Journal of Ginseng Research, 2023 Background: Ginseng contains three active components: ginsenosides, gintonin, and polysaccharides. After the separation of 1 of the 3 ingredient fractions, other fractions are usually discarded as waste. In this study, we developed a simple and effective
Rami Lee +11 more
doaj +2 more sources
Ginseng pharmacology: a new paradigm based on gintonin-lysophosphatidic acid receptor interactions [PDF]
Frontiers in Pharmacology, 2015 Ginseng, the root of Panax ginseng, is used as a traditional medicine. Despite the long history of the use of ginseng, there is no specific scientific or clinical rationale for ginseng pharmacology besides its application as a general tonic.
Seung-Yeol eNah +6 more
doaj +2 more sources