Results 21 to 30 of about 653 (163)
Hippocampus-dependent cognitive enhancement induced by systemic gintonin administration
Journal of Ginseng Research, 2016 Background: A number of neurological and neurodegenerative diseases share impaired cognition as a common symptom. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest.
Sungmin Kim +7 more
doaj +3 more sources
Neurolipid systems: A new target for the treatment of dementia [PDF]
Basic &Clinical Pharmacology &Toxicology, Volume 135, Issue 3, Page 225-236, September 2024.Neurolipids comprise a diverse class of bioactive lipids that include molecules capable of activating G protein-coupled receptors, thereby inducing systemic effects that contribute to the maintenance of homeostasis.
Bengoetxea de Tena, Iker +6 more
core +2 more sources
Effects of gintonin-enriched fraction on hippocampal gene expressions
Integrative Medicine Research, 2021 Background: Recently, gintonin and gintonin-enriched fraction (GEF) have been isolated from ginseng, a herbal medicine. Gintonin induces [Ca2+]i transition in cultured hippocampal neurons and stimulates acetylcholine release through LPA receptor ...
Rami Lee +8 more
doaj +3 more sources
Gintonin Isolated from Ginseng Inhibits the Epithelial—Mesenchymal Transition Induced by TGF-β in A549 Lung Cancer Cells [PDF]
Plants, 2023 Epithelial-to-mesenchymal transition (EM transition) is a process wherein epithelial cells lose their intrinsic characteristics and cell–cell junctions and differentiate into a mesenchymal phenotype.
Sung Jin Kim +4 more
doaj +2 more sources
Cognitive function improvement effects of gintonin-enriched fraction in subjective memory impairment: An assessor- and participant-blinded placebo-controlled study [PDF]
Journal of Ginseng Research, 2023 Background: Gintonin is a new material of ginseng that acts through the ginseng-derived lysophosphatidic acid (LPA) receptor ligand. The gintonin-enriched fraction (GEF) inhibits amyloid plaque accumulation in the cortex and hippocampus, improves ...
Rami Lee +4 more
doaj +2 more sources
Journal of Ginseng Research, 2021 Background: We recently showed that gintonin, an active ginseng ingredient, exhibits antibrain neurodegenerative disease effects including multiple target mechanisms such as antioxidative stress and antiinflammation via the lysophosphatidic acid (LPA ...
Sung Min Nam, Sun-Hye Choi, Hee-Jung Cho
exaly +3 more sources
Gintonin-Enriched Fraction Suppresses Heat Stress-Induced Inflammation through LPA Receptor [PDF]
Molecules, 2020 Heat stress can be caused by various environmental factors. When exposed to heat stress, oxidative stress and inflammatory reaction occur due to an increase of reactive oxygen species (ROS) in the body.
Sungwoo Chei +7 more
doaj +3 more sources
Ginseng Nanosizing: The Second Spring of Ginseng Therapeutic Applications [PDF]
AntioxidantsPlant-derived vesicles offer several advantages, including high yield, low cost, ethical compatibility, safety, and potential health benefits. These advantages enable them to overcome technological limitations associated with vesicles of mammalian origin.
Jian Wang +8 more
doaj +2 more sources
Amelioration of muscle wasting by gintonin in cancer cachexia
Neoplasia: An International Journal for Oncology Research, 2021 Cancer cachexia is characterized by systemic inflammation, protein degradation, and loss of skeletal muscle. Despite extensive efforts to develop therapeutics, only few effective treatments are available to protect against cancer cachexia. Here, we found
Yoseph Toni Wijaya +4 more
doaj +3 more sources
Frontiers in Pharmacology, 2018 Gintonin is a ginseng-derived lysophosphatidic acid receptor (LPAR) ligand. Although previous in vitro and in vivo studies demonstrated the therapeutic role of gintonin against Alzheimer’s disease, the neuroprotective effects of gintonin in Parkinson’s ...
Seikwan Oh, Seung-Yeol Nah, Ik-Hyun Cho
exaly +3 more sources