Involvement of LPA Receptor 3 in LPA-induced BGC- 803 Cell Migration [PDF]
Mongolian Journal of Biological Sciences, 2013 Lysophosphatidic acid ˄ LPA ˅ is a bioactive phospholipid mediator, which elicits a variety of biological functions mainly through G-protein coupled receptors. Although LPA is shown to stimulate proliferation and motility via LPA receptors, LPAR1
Erdene Oyungerel +4 more
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Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA‐binding proteins in activation of LPA receptors [PDF]
FEBS Letters, 2002 Lysophosphatidic acid (LPA) exerts multiple biological functions through G protein‐coupled receptors (EDG2/LPA1, EDG4/LPA2, and EDG7/LPA3) and is present in serum where it is associated with albumin. In this study we examined LPA activity in various biological fluids by measuring the LPA‐induced increase in the intracellular concentration of calcium ...
Junken Aoki
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Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species [PDF]
FEBS Letters, 2000 We examined the structure–activity relationship of cloned lysophosphatidic acid (LPA) receptors (endothelial cell differentiation gene (EDG) 2, EDG4, and EDG7) by measuring [Ca2+]i in Sf9 insect cells expressing each receptor using LPA with various acyl chains bound at either the sn‐1 or the sn‐2 position of the glycerol backbone.
Junken Aoki, Hiroyuki Arai
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Structural mechanisms underlying distinct binding and activities of 18:0 and 18:1 lysophosphatidic acids at LPA1 receptor. [PDF]
PLoS Computational BiologyLysophosphatidic acids (LPAs) are bioactive lipids that regulate numerous physiological functions in humans. Cell signaling by LPAs is mediated mainly via six LPA receptors (LPA1-6), class A G protein-coupled receptors (GPCRs).
Ayobami Diyaolu +4 more
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LPA receptor signaling: pharmacology, physiology, and pathophysiology [PDF]
Journal of Lipid Research, 2014 Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and nonvertebrate organisms that mediates diverse biological actions and demonstrates medicinal relevance. LPA's functional roles are driven by extracellular signaling through at
Yun C. Yung +2 more
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Effects of the LPA1 Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice [PDF]
Frontiers in Molecular Neuroscience, 2019 Lysophosphatidic acid (LPA) is an important bioactive lipid species that functions in intracellular signaling through six characterized G protein-coupled receptors (LPA1-6). Among these receptors, LPA1 is a strong candidate to mediate the central effects
Sara Tabbai +12 more
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Lysophosphatidic acid promotes endometrial decidualization in recurrent implantation failure patients by regulating LPAR6 [PDF]
Frontiers in Cell and Developmental BiologyBackgroundImpaired decidualization is associated with recurrent implantation failure (RIF) and lysophosphatidic acid (LPA) is known to play an important role in decidua formation.
Shanshan Wang +5 more
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Cells, 2021 Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled receptors, termed LPA receptors (LPAR1 to LPAR6).
Yu-Hsuan Lin +2 more
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The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA. [PDF]
PLoS ONE, 2012 Lysophosphatidic acid (LPA) mediates diverse cellular responses through the activation of at least six LPA receptors--LPA(1-6,) but the interacting proteins and signaling pathways that mediate the specificity of these receptors are largely unknown.
Tal Varsano +4 more
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Frontiers in Pharmacology, 2022 Lysophosphatidic acid (LPA), a lipid metabolite, plays a role in both neuropathic and inflammatory pain through LPA1 receptors. P2X3 receptor has also been shown to participate in these pathological processes.
Wen-Long Qiao +12 more
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