Results 21 to 30 of about 18,471 (244)
Regulation of T cell motility in vitro and in vivo by LPA and LPA2. [PDF]
PLoS ONE, 2014 Lysophosphatidic acid (LPA) and the LPA-generating enzyme autotaxin (ATX) have been implicated in lymphocyte trafficking and the regulation of lymphocyte entry into lymph nodes.
Sara A Knowlden +6 more
doaj +1 more source
Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors [PDF]
, 1998 Regulation of serum response factor (SRF)-mediated gene transcription by G protein subunits and G protein-coupled receptors was investigated in transfected NIH3T3 cells and in a cell line that was derived from mice lacking G_(αq) and G_(α11).
Mao, Junhao +4 more
core +1 more source
Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors [PDF]
, 2018 Chemokines are secreted proteins that regulate a range of processes in eukaryotic organisms. Interestingly, different chemokine receptors control distinct biological processes, and the same receptor can direct different cellular responses, but the basis ...
Malhotra, Divyanshu +3 more
core +2 more sources
Frontiers in Molecular Neuroscience, 2020 Lysophosphatidic acid is a small extracellular signaling molecule, which is elevated in pathological conditions such as ischemic stroke and traumatic brain injury (TBI). LPA regulates the survival of neurons in various diseases.
Jie Zhang +6 more
doaj +1 more source
Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]
, 2006 Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
core +1 more source
Molecular Pain, 2013 Background We previously reported that nerve injury-induced neuropathic pain is initiated by newly produced lysophosphatidic acid (LPA). Results In this study, we developed a quantitative mass spectrometry for detecting LPA species by using Phos-tag ...
Lin Ma +3 more
doaj +1 more source
Inference of the drivers of collective movement in two cell types: Dictyostelium and melanoma [PDF]
, 2016 Collective cell movement is a key component of many important biological processes, including wound healing, the immune response and the spread of cancers.
Ferguson, Elaine A. +3 more
core +2 more sources
Mediators of Inflammation, 2022 Lysophosphatidic acid (LPA) has disruptive effects on lumbar spinal stenosis (LSS). Recently, LPA has been reported to be involved in spinal cord neuronal injury and toxicity, promoting the pathogenesis of LSS. However, the exact effects of LPA on spinal
Yifan Yang +6 more
doaj +1 more source
Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]
, 2007 G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung +6 more
core +2 more sources
Molecular Pain, 2014 Background: Paclitaxel, which is widely used for the treatment of solid tumors, causes neuropathic pain via poorly understood mechanisms. Previously, we have demonstrated that lysophosphatidic acid (LPA) and its receptors (LPA 1 and LPA 3 ) are required ...
Hitoshi Uchida, Jun Nagai, Hiroshi Ueda
doaj +1 more source