Results 21 to 30 of about 9,759 (160)

Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. [PDF]

PLoS ONE, 2013
Lysophosphatidic acid (LPA) is a pleiotropic phospholipid present in the blood and certain tissues at high concentrations; its diverse effects are mediated through differential, tissue specific expression of LPA receptors.
Denis Evseenko, Brooke Latour, Wade Richardson, Mirko Corselli, Arineh Sahaghian, Sofie Cardinal, Yuhua Zhu, Rebecca Chan, Bruce Dunn, Gay M Crooks   +9 more
doaj   +1 more source

Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway

Frontiers in Molecular Neuroscience, 2020
Lysophosphatidic acid is a small extracellular signaling molecule, which is elevated in pathological conditions such as ischemic stroke and traumatic brain injury (TBI). LPA regulates the survival of neurons in various diseases.
Jie Zhang, Yiyi Li, Chao Wang, Yaya Wang, Yangyang Zhang, Liqin Huang, Zhaohui Zhang   +6 more
doaj   +1 more source

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist [PDF]

Proceedings of the National Academy of Sciences, 2002
Lysophosphatidic acid (LPA) is a pluripotent lipid mediator acting through plasma membrane-associated LPA x receptors that transduce many, but not all, of its effects. We identify peroxisome proliferator-activated receptor γ (PPARγ) as an intracellular receptor for LPA.
Thomas M, McIntyre, Aaron V, Pontsler, Adriana R, Silva, Andy, St Hilaire, Yong, Xu, Jerald C, Hinshaw, Guy A, Zimmerman, Kotaro, Hama, Junken, Aoki, Hiroyuki, Arai, Glenn D, Prestwich   +10 more
openaire   +2 more sources

An LPA Species (18:1 LPA) Plays Key Roles in the Self-Amplification of Spinal LPA Production in the Peripheral Neuropathic Pain Model

Molecular Pain, 2013
Background We previously reported that nerve injury-induced neuropathic pain is initiated by newly produced lysophosphatidic acid (LPA). Results In this study, we developed a quantitative mass spectrometry for detecting LPA species by using Phos-tag ...
Lin Ma, Jun Nagai, Jerold Chun, Hiroshi Ueda   +3 more
doaj   +1 more source

Lysophosphatidic Acid Induced Apoptosis, DNA Damage, and Oxidative Stress in Spinal Cord Neurons by Upregulating LPA4/LPA6 Receptors

Mediators of Inflammation, 2022
Lysophosphatidic acid (LPA) has disruptive effects on lumbar spinal stenosis (LSS). Recently, LPA has been reported to be involved in spinal cord neuronal injury and toxicity, promoting the pathogenesis of LSS. However, the exact effects of LPA on spinal
Yifan Yang, Jing Xu, Qingxin Su, Yiran Wu, Qizheng Li, Zongren Ma, Tao Ding   +6 more
doaj   +1 more source

Autotaxin facilitates selective LPA receptor signaling

Cell Chemical Biology, 2023
Autotaxin (ATX; ENPP2) produces the lipid mediator lysophosphatidic acid (LPA) that signals through disparate EDG (LPA1-3) and P2Y (LPA4-6) G protein-coupled receptors. ATX/LPA promotes several (patho)physiological processes, including in pulmonary fibrosis, thus serving as an attractive drug target.
Fernando Salgado-Polo, Razvan Borza, Minos-Timotheos Matsoukas, Florence Marsais, Catherine Jagerschmidt, Ludovic Waeckel, Wouter H. Moolenaar, Paul Ford, Bertrand Heckmann, Anastassis Perrakis   +9 more
openaire   +2 more sources

LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.

PLoS ONE, 2011
Lysophosphatidic acid (LPA), a lipid mediator enriched in serum, stimulates cell migration, proliferation and other functions in many cell types. LPA acts on six known G protein-coupled receptors, termed LPA(1-6), showing both overlapping and distinct ...
Maikel Jongsma, Elisa Matas-Rico, Adrian Rzadkowski, Kees Jalink, Wouter H Moolenaar   +4 more
doaj   +1 more source

Advances in lysophosphatidic acid for bone remodeling [PDF]

Kouqiang yixue
Lysophosphatidic acid (LPA), a simple bioactive lysophospholipid widely dispersed in human body, has been reported to regulate the proliferation, chemotaxis and differentiation of multiple cells and further participate in various developmental and ...
ZHANG Qin, XIANG Lin, GONG Ping
doaj   +1 more source

Lysophosphatidic Acid and its Receptors LPA and LPA Mediate Paclitaxel-Induced Neuropathic Pain in Mice

Molecular Pain, 2014
Background: Paclitaxel, which is widely used for the treatment of solid tumors, causes neuropathic pain via poorly understood mechanisms. Previously, we have demonstrated that lysophosphatidic acid (LPA) and its receptors (LPA 1 and LPA 3 ) are required ...
Hitoshi Uchida, Jun Nagai, Hiroshi Ueda
doaj   +1 more source

2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition

Scientific Reports, 2021
Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator that, along with its chemically stabilized analogue 2-carba-cyclic phosphatidic acid (2ccPA), induces various biological activities in vitro and in vivo.
Keiko Fukasawa, Mari Gotoh, Akiharu Uwamizu, Takatsugu Hirokawa, Masaki Ishikawa, Yoshibumi Shimizu, Shinji Yamamoto, Kensuke Iwasa, Keisuke Yoshikawa, Junken Aoki, Kimiko Murakami-Murofushi   +10 more
doaj   +1 more source