Results 31 to 40 of about 9,759 (160)
Mammary Tumorigenesis through LPA Receptor Signaling [PDF]
Cancer Cell, 2009 Lysophosphatidic acid (LPA) is a lipid growth factor that is produced by an extracellular phospholipase, termed autotaxin (ATX), and acts via G protein-coupled receptors. In this issue of Cancer Cell, Liu et al. show that transgenic overexpression of ATX or LPA receptors leads to invasive and metastatic mammary cancer.
Jonkers, Jos, Moolenaar, Wouter H.
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Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies
Signal Transduction and Targeted Therapy, 2021 Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review the literature about the differential signaling of LPA through its specific receptors, which ...
Luiz Henrique Medeiros Geraldo +8 more
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The Scientific World Journal, 2002 The physiological lysophospholipids (LPLs), exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are omnific mediators of normal cellular proliferation, survival, and functions.
Edward J. Goetzl +3 more
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Frontiers in Pharmacology, 2023 Lysophosphatidic acid (LPA) is a bioactive phospholipid that acts as an agonist of six G protein-coupled receptors named LPA receptors (LPA1-6).
C. Ruzza +7 more
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BMC Women's Health, 2017 Background Given the important roles of the receptor-mediated lysophosphatidic acid (LPA) signaling in both reproductive tract function and gynecological cancers, it will be informative to investigate the potential role of LPA in the development of ...
Bicheng Yang +8 more
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Regulation of LPA receptor function by estrogens
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2008 17beta-Estradiol induced LPA(1) receptor desensitization in C9 cells stably expressing LPA(1) receptors and transiently expressing estrogen receptor alpha. Such desensitization was evidenced by a reduction in lysophosphatidic acid-mediated Ca(2+)mobilization and it was associated to receptor phosphorylation and internalization.
González-Arenas, Aliesha +6 more
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Journal of Ginseng Research, 2022 Gintonin is a ginseng-derived exogenous G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. Gintonin exerts its neuronal and non-neuronal in vitro and in vivo effects through LPA receptor subtypes. However, it is unknown whether gintonin can bind to the plasma membrane of cells and can transactivate the epidermal growth factor (EGF) receptor.
Sun-Hye Choi +9 more
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ATX-LPA receptor axis in inflammation and cancer [PDF]
Cell Cycle, 2009 Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) mediates a plethora of physiological and pathological activities via interactions with a series of high affinity G protein-coupled receptors (GPCR). Both LPA receptor family members and autotaxin (ATX/LysoPLD), the primary LPA-producing enzyme, are aberrantly expressed in many human ...
Shuying, Liu +3 more
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Journal of Lipid Research, 2011 Lysophosphatidic acid (LPA) is a bioactive lysophospholipid present in low concentrations in serum and biological fluids but in high concentrations at sites of inflammation.
Chenqi Zhao +5 more
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Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development
Mediators of Inflammation, 2017 Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA1–6, to induce
Silvia Anahi Valdés-Rives +1 more
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