Results 11 to 20 of about 9,759 (160)

Lateral Preoptic Area Neurons Activated by Angiotensin-(1–7) Increase Intravesical Pressure: A Novel Feature in Central Micturition Control

Frontiers in Physiology, 2021
Central micturition control and urine storage involve a multisynaptic neuronal circuit for the efferent control of the urinary bladder. Electrical stimulation of the lateral preoptic area (LPA) at the level of the decussation of the anterior commissure ...
Gustavo B. Lamy, Eduardo M. Cafarchio, Bárbara do Vale, Bruno B. Antonio, Daniel P. Venancio, Janaina S. de Souza, Rui M. Maciel, Gisele Giannocco, Gisele Giannocco, Patrik Aronsson, Monica A. Sato   +10 more
doaj   +1 more source

Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers. [PDF]

PLoS ONE, 2014
Lysophosphatidic acid (LPA) is a natural bioactive lipid with growth factor-like functions due to activation of a series of six G protein-coupled receptors (LPA₁₋₆).
Marion David, Debashish Sahay, Florence Mege, Françoise Descotes, Raphaël Leblanc, Johnny Ribeiro, Philippe Clézardin, Olivier Peyruchaud   +7 more
doaj   +1 more source

The LPA-CDK5-tau pathway mediates neuronal injury in an in vitro model of ischemia-reperfusion insult

BMC Neurology, 2022
Lysophosphatidic acid (LPA) is a common glycerol phospholipid and an important extracellular signaling molecule. LPA binds to its receptors and mediates a variety of biological effects, including the pathophysiological process underlying ischemic brain ...
Yaya Wang, Jie Zhang, Liqin Huang, Yanhong Mo, Changyu Wang, Yiyi Li, Yangyang Zhang, Zhaohui Zhang   +7 more
doaj   +1 more source

Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA So Special?

Cells, 2021
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for G protein-coupled receptors. While LPA exerts effects throughout the body in normal physiological circumstances, its pathological role in cancer is of great ...
Pravita Balijepalli, Ciera C. Sitton, Kathryn E. Meier   +2 more
doaj   +1 more source

Lysophosphatidic acid exerts protective effects on HEI-OC1 cells against cytotoxicity of cisplatin by decreasing apoptosis, excessive autophagy, and accumulation of ROS

Cell Death Discovery, 2023
Lysophosphatidic acid (LPA) is an active phospholipid signaling molecule that binds to six specific G protein-coupled receptors (LPA1-6) on the cell surface and exerts a variety of biological functions, including cell migration and proliferation ...
Xiaogang An, Cuiping Zhong, Bang Han, Erfang Chen, Qingwen Zhu, Yang Yang, Rui Li, Runqin Yang, Dingjun Zha, Yu Han   +9 more
doaj   +1 more source

Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain

Molecular Pain, 2009
Background We previously reported that intrathecal injection of lysophosphatidylcholine (LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 receptor, possibly via conversion to LPA by autotaxin (ATX).
Aoki Junken, Chun Jerold, Inoue Makoto, Nagai Jun, Uchida Hitoshi, Ma Lin, Ueda Hiroshi   +6 more
doaj   +1 more source

Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature.

PLoS ONE, 2011
Despite wide margins and high dose irradiation, unresectable malignant glioma (MG) is less responsive to radiation and is uniformly fatal. We previously found that cytosolic phospholipase A2 (cPLA(2)) is a molecular target for radiosensitizing cancer ...
Stephen M Schleicher, Dinesh K Thotala, Amanda G Linkous, Rong Hu, Kathleen M Leahy, Eugenia M Yazlovitskaya, Dennis E Hallahan   +6 more
doaj   +1 more source

Role of lysophosphatidic acid receptor LPA₂ in the development of allergic airway inflammation in a murine model of asthma

Respiratory Research, 2009
Background Lysophosphatidic acid (LPA) plays a critical role in airway inflammation through G protein-coupled LPA receptors (LPA1-3). We have demonstrated that LPA induced cytokine and lipid mediator release in human bronchial epithelial cells.
Chun Jerold, Evgeny Berdyshev, Pendyala Srikanth, He Donghong, Tong Jiankun, Zhao Yutong, Sperling Anne I, Natarajan Viswanathan   +7 more
doaj   +1 more source

Non-Edg family LPA receptors: the cutting edge of LPA research [PDF]

Journal of Biochemistry, 2011
Lysophosphatidic acid (LPA) is a bioactive lipid mediator with diverse physiological and pathological actions on many types of cells. Originally, LPA was thought to elicit its biological functions through three subtypes of endothelial differentiation gene (Edg) family G protein-coupled receptors (LPA1, LPA2 and LPA3) until our group identified a fourth
Keisuke, Yanagida, Satoshi, Ishii
openaire   +2 more sources

Regulation of T cell motility in vitro and in vivo by LPA and LPA2. [PDF]

PLoS ONE, 2014
Lysophosphatidic acid (LPA) and the LPA-generating enzyme autotaxin (ATX) have been implicated in lymphocyte trafficking and the regulation of lymphocyte entry into lymph nodes.
Sara A Knowlden, Tara Capece, Milan Popovic, Timothy J Chapman, Fariba Rezaee, Minsoo Kim, Steve N Georas   +6 more
doaj   +1 more source