Results 41 to 50 of about 9,759 (160)

Lysophosphatidic Acid and Glutamatergic Transmission

Frontiers in Molecular Neuroscience, 2019
Signaling through bioactive lipids regulates nervous system development and functions. Lysophosphatidic acid (LPA), a membrane-derived lipid mediator particularly enriched in brain, is able to induce many responses in neurons and glial cells by affecting
Carolina Roza, José A. Campos-Sandoval, María C. Gómez-García, Ana Peñalver, Javier Márquez   +4 more
doaj   +1 more source

Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.

PLoS ONE, 2016
Hepatocellular carcinoma (HCC) commonly develops in patients with liver fibrosis; in these patients, the blood levels of lysophosphatidic acid (LPA) and its generating enzyme autotaxin (ATX) increase with the liver fibrosis stage. We aimed to examine the
Kenichiro Enooku, Baasanjav Uranbileg, Hitoshi Ikeda, Makoto Kurano, Masaya Sato, Hiroki Kudo, Harufumi Maki, Kazuhiko Koike, Kiyoshi Hasegawa, Norihiro Kokudo, Yutaka Yatomi   +10 more
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Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells

FEBS Open Bio, 2014
Fatty-acid-binding protein 3, muscle and heart (FABP3), also known as heart-type FABP, is a member of the family of intracellular lipid-binding proteins. It is a small cytoplasmic protein with a molecular mass of about 15 kDa.
Ryoko Tsukahara, Hisao Haniu, Yoshikazu Matsuda, Tamotsu Tsukahara   +3 more
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LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1β release. [PDF]

PLoS ONE, 2011
Lysophosphatidic acid (LPA) is a bioactive lipid inducing proliferation, differentiation as well as cytokine release by mast cells through G-protein coupled receptors. Recently GPR92/LPA5 was identified as an LPA receptor highly expressed by cells of the
Anders Lundequist, Joshua A Boyce
doaj   +1 more source

Lysophosphatidic acid and itsreceptors: Role in bronchial asthma pathogenesis

Acta Biomedica Scientifica
Lysophosphatidic acid (LPA) is a biologically active lipid mediator that regulates a number ofsignaling pathways involved in the pathogenesis of bronchial asthma.
O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko   +2 more
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Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity

Cellular Physiology and Biochemistry, 2017
Background/Aims: Obesity is a main risk factor for the development of hepatic insulin resistance and it is accompanied by adipocyte hypertrophy and an elevated expression of different adipokines such as autotaxin (ATX).
Susann Fayyaz, Lukasz Japtok, Fabian Schumacher, Dominik  Wigger, Tim Julius Schulz, Kathrin  Haubold, Erich Gulbins, Heinz  Völler, Burkhard Kleuser   +8 more
doaj   +1 more source

Unlabeled lysophosphatidic acid receptor binding in free solution as determined by a compensated interferometric reader

Journal of Lipid Research, 2020
Native interactions between lysophospholipids (LPs) and their cognate LP receptors are difficult to measure because of lipophilicity and/or the adhesive properties of lipids, which contribute to high levels of nonspecific binding in cell membrane ...
Manisha Ray, Kazufumi Nagai, Yasuyuki Kihara, Amanda Kussrow, Michael N. Kammer, Aaron Frantz, Darryl J. Bornhop, Jerold Chun   +7 more
doaj   +1 more source

CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts

Respiratory Research, 2021
Background Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrotic signaling in the lower ...
Shyam Nathan, Haijun Zhang, Mirko Andreoli, Philip L. Leopold, Ronald G. Crystal   +4 more
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LPA receptor 1 mediates LPA-induced ovarian cancer metastasis: an in vitro and in vivo study [PDF]

BMC Cancer, 2016
The facts that LPA is present at high concentration in ovarian cancer patients' ascites and it may serve as a stimulator to cell migration, implicate the role of LPA in the ovarian cancer metastasis. Since LPA mediates various biological functions through its interaction with LPA receptors, we aim to investigate the correlation between the expression ...
Yu, Xuechen, Zhang, Yuanzhen, Chen, Huijun   +2 more
openaire   +2 more sources

Lysophospholipid receptors in neurodegeneration and neuroprotection

Exploration of Neuroprotective Therapy
The central nervous system (CNS) is one of the most complex physiological systems, and treatment of CNS disorders represents an area of major medical need.
Eric Birgbauer
doaj   +1 more source