Results 51 to 60 of about 9,759 (160)

β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1. [PDF]

PLoS ONE, 2013
β-Arrestins play critical roles in chemotaxis and cytoskeletal reorganization downstream of several receptor types, including G protein-coupled receptors (GPCRs), which are targets for greater than 50% of all pharmaceuticals.
Mistre Alemayehu, Magdalena Dragan, Cynthia Pape, Iram Siddiqui, David B Sacks, Gianni M Di Guglielmo, Andy V Babwah, Moshmi Bhattacharya   +7 more
doaj   +1 more source

Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction

Frontiers in Physiology, 2014
In vascular smooth muscle cells (VSMC) increased integrin adhesion to extracellular matrix (ECM) proteins, as well as the production of reactive oxygen species (ROS) are strongly stimulated by lysophosphatidic acid (LPA). We hypothesized that LPA-induced
Marius C. Staiculescu, Francisco I. Ramirez-Perez, Francisco I. Ramirez-Perez, Jorge A. Castorena-Gonzalez, Jorge A. Castorena-Gonzalez, Zhongkui eHong, Zhe eSun, Gerald A. Meininger, Gerald A. Meininger, Gerald A. Meininger, Luis A. Martinez-Lemus, Luis A. Martinez-Lemus, Luis A. Martinez-Lemus   +12 more
doaj   +1 more source

Lateral access mechanism of LPA receptor probed by molecular dynamics simulation.

PLoS ONE, 2022
G-protein-coupled receptors (GPCR) are a family of membrane receptors that play important roles in the regulation of various physiological phenomena. LPA receptors (LPA1-6) are members of the class A GPCRs, which transduce a lysophosphatidic acid (LPA ...
Rieko Suenaga, Mizuki Takemoto, Asuka Inoue, Ryuichiro Ishitani, Osamu Nureki   +4 more
doaj   +1 more source

Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profiling

BMC Genomics, 2008
Background Lysophosphatidic acid (LPA) is a lipid mediator that acts through specific G protein-coupled receptors to stimulate the proliferation, migration and survival of many cell types.
Moolenaar Wouter H, Kerkhoven Ron, Stortelers Catelijne   +2 more
doaj   +1 more source

Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device

BMC Cancer, 2017
Background Migration of cancer cell correlates with distant metastasis and local invasion, which are good targets for cancer treatment. An optically accessible device “TAXIScan” was developed, which provides considerably more information regarding the ...
Akira Yamauchi, Masahiro Yamamura, Naoki Katase, Masumi Itadani, Naoko Okada, Kayoko Kobiki, Masafumi Nakamura, Yoshiyuki Yamaguchi, Futoshi Kuribayashi   +8 more
doaj   +1 more source

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Nature Communications, 2018
Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-
Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes, Richard J. A. Wilson   +8 more
doaj   +1 more source

Translational research on autotaxin-LPA-LPA receptors and drug discovery

Clinical Lipidology, 2015
The discovery that lysophosphatidic acid (LPA) acts as a signaling molecule via its G protein-coupled receptors motivated studies on the signaling and pathophysiology of LPA. Furthermore, the subsequent identification of the LPA-producing plasma phosphodiesterase, autotaxin, led to structural and mouse genetic studies of this lysophospholipase D ...
openaire   +1 more source

Gintonin influences the morphology and motility of adult brain neurons via LPA receptors. [PDF]

J Ginseng Res, 2021
Kim DG, Kim HJ, Choi SH, Nam SM, Kim HC, Rhim H, Cho IH, Rhee MH, Nah SY.   +8 more
europepmc   +1 more source

Autotaxin in Pathophysiology and Pulmonary Fibrosis

Frontiers in Medicine, 2018
Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in idiopathic pulmonary fibrosis (IPF) patients.
Ioanna Ninou, Christiana Magkrioti, Vassilis Aidinis   +2 more
doaj   +1 more source

Lysophospholipid receptors LPA1–3 are not required for the inhibitory effects of LPA on mouse retinal growth cones

Eye and Brain, 2010
Eric Birgbauer, Jerold ChunDepartment of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA, USA Abstract: One of the major requirements in the development of the visual ...
Eric Birgbauer, Jerold Chun
doaj