Results 71 to 80 of about 18,471 (244)
Respiratory Research, 2021 Background Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrotic signaling in the lower ...
Shyam Nathan +4 more
doaj +1 more source
FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer [PDF]
, 2015 Lysophosphatidic acid (LPA), a prototypical ligand for G protein coupled receptors, and Forkhead box protein M1 (FOXM1), a transcription factor that regulates expression of a wide array of genes involved in cancer initiation and progression, are two ...
Cai, Qingchun, Fan, Qipeng, Xu, Yan
core +3 more sources
Conspiracy Theory Endorsement Profiles: A Cluster Validation Study
European Journal of Social Psychology, EarlyView.ABSTRACT A substantial body of research has investigated the determinants of conspiratorial beliefs, yet little is known about different conspiracy theory endorsement profiles. The present study used cluster analysis on a set of 52 conspiratorial statements tapping into six conspiracy theory types to identify and validate conspiracy theory endorsement ...
Otto Mäki +6 more
wiley +1 more source
Lysophosphatidic acid and itsreceptors: Role in bronchial asthma pathogenesis
Acta Biomedica ScientificaLysophosphatidic acid (LPA) is a biologically active lipid mediator that regulates a number ofsignaling pathways involved in the pathogenesis of bronchial asthma.
O. Yu. Kytikova +2 more
doaj +1 more source
Human Resource Development Quarterly, EarlyView.ABSTRACT With the increasing adoption of Artificial Intelligence (AI) in the workplace, employees' career paths have become more diverse and less predictable in the era of Industry 4.0. As technological transformations accelerate, employee turnover patterns are also changing, as reflected in the growing prevalence of occupational transitions and large ...
Young‐Kook Moon, Tanya Mitropoulos
wiley +1 more source
β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1. [PDF]
PLoS ONE, 2013 β-Arrestins play critical roles in chemotaxis and cytoskeletal reorganization downstream of several receptor types, including G protein-coupled receptors (GPCRs), which are targets for greater than 50% of all pharmaceuticals.
Mistre Alemayehu +7 more
doaj +1 more source
, 2018 Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life.
Elsadek, Bakheet, Maqboul, Ahmad
core +2 more sources
Physiopathological Implications of 7TM Receptors [PDF]
, 2010 Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core +2 more sources
InfoMat, EarlyView.Lead‐free inorganic halide perovskites enable resistive switching synaptic devices capable of mimicking biological learning and multimodal information processing, offering a promising platform for next‐generation neuromorphic computing and artificial intelligence hardware. Abstract Inorganic halide perovskites (IHPs) have emerged as promising materials
Subhasish Chanda +7 more
wiley +1 more source
Lysophospholipid receptors in neurodegeneration and neuroprotection
Exploration of Neuroprotective TherapyThe central nervous system (CNS) is one of the most complex physiological systems, and treatment of CNS disorders represents an area of major medical need.
Eric Birgbauer
doaj +1 more source