Results 81 to 90 of about 18,471 (244)

Lateral access mechanism of LPA receptor probed by molecular dynamics simulation.

PLoS ONE, 2022
G-protein-coupled receptors (GPCR) are a family of membrane receptors that play important roles in the regulation of various physiological phenomena. LPA receptors (LPA1-6) are members of the class A GPCRs, which transduce a lysophosphatidic acid (LPA ...
Rieko Suenaga, Mizuki Takemoto, Asuka Inoue, Ryuichiro Ishitani, Osamu Nureki   +4 more
doaj   +1 more source

An essential role for LPA signalling in telencephalon development [PDF]

, 2014
Lysophosphatidic acid (LPA) has wide-ranging effects on many different cell types, acting through G-protein-coupled receptors such as LPAR6. We show that Xenopus lpar6 is expressed from late blastulae and is enriched in the mesoderm and dorsal ectoderm ...
Amaya, Bachy, Branney, Choi, Christen, Christen, Chun, Conlon, Contos, Contos, Dale, Dorey, Dubin, Eagleson, Elul, Estivill-Torrús, Fisher, Fletcher, Fotopoulou, Geach, Hecht, Herzog, Hoch, Hongo, Hébert, Inoue, Isaacs, Isaacs, Isaacs, Janssens, Kaplan, Kazantseva, Koike, Koike, LaBonne, Lea, Lee, Lee, Li, Lin, Lloyd, Lupo, Massé, Massé, Meyers, Mohammadi, Moody, Nie, Noguchi, Ohuchi, Paek, Papalopulu, Pasternack, Pasternack, Pownall, Shanmugalingam, Shimamura, Shimomura, Shimomura, Shimomura, Sive, Skoura, Small, Smith, Standley, Tokumura, Umezu-Goto, van Meeteren, Wallingford, Walshe, Webb, Wilson, Yanagida, Ye   +73 more
core   +2 more sources

Social Class Discrimination and Academic Success: A Person‐Centered Approach Among Adolescents Disadvantaged in Social Class

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Prior research indicates that social class is strongly associated with academic outcomes such as GPA. However, little work explores the role that social discrimination plays in this relation. This study examined the link between social class discrimination and academic outcomes among high school students.
Christine R. Starr, Anna P. Veenendall, Zena R. Mello   +2 more
wiley   +1 more source

Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction

Frontiers in Physiology, 2014
In vascular smooth muscle cells (VSMC) increased integrin adhesion to extracellular matrix (ECM) proteins, as well as the production of reactive oxygen species (ROS) are strongly stimulated by lysophosphatidic acid (LPA). We hypothesized that LPA-induced
Marius C. Staiculescu, Francisco I. Ramirez-Perez, Francisco I. Ramirez-Perez, Jorge A. Castorena-Gonzalez, Jorge A. Castorena-Gonzalez, Zhongkui eHong, Zhe eSun, Gerald A. Meininger, Gerald A. Meininger, Gerald A. Meininger, Luis A. Martinez-Lemus, Luis A. Martinez-Lemus, Luis A. Martinez-Lemus   +12 more
doaj   +1 more source

A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. [PDF]

, 2016
With the passing of Dr. Robert Bittman from pancreatic cancer on the 1st October 2014, the lipid research field lost one of the most influential and significant personalities.
Pyne, Nigel J., Tigyi, Gabor J.
core   +1 more source

Mapping the Adolescent Mind: Profiles of Reflective Functioning and Epistemic Trust in Adolescent Psychopathology

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Adolescence is a period of heightened vulnerability to psychopathology, when capacities for mentalising and interpersonal trust develop rapidly. This study investigated how configurations of reflective functioning (RF) and epistemic trust (ET) differentiate patterns of internalizing and externalizing problems in youth.
Ilaria Maria Antonietta Benzi, Nick Midgley, Karin Ensink, Laura Parolin, Peter Fonagy, Francesca Locati   +5 more
wiley   +1 more source

The Role of Self‐Compassion and Experience in Psychologists' Latent Emotional Labour Strategy Profiles

Journal of Clinical Psychology, EarlyView.
ABSTRACT Objective Emotional labour has long been associated with personal and organizational outcomes such as burnout. However, theoretically dichotomising regulation into surface and deep acting may constrain the ecological validity of research as iterative and person‐centered approaches to emotion regulation are not considered.
James J. Clarke, Vincent O. Mancini, Clare S. Rees, Lauren J. Breen   +3 more
wiley   +1 more source

Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device

BMC Cancer, 2017
Background Migration of cancer cell correlates with distant metastasis and local invasion, which are good targets for cancer treatment. An optically accessible device “TAXIScan” was developed, which provides considerably more information regarding the ...
Akira Yamauchi, Masahiro Yamamura, Naoki Katase, Masumi Itadani, Naoko Okada, Kayoko Kobiki, Masafumi Nakamura, Yoshiyuki Yamaguchi, Futoshi Kuribayashi   +8 more
doaj   +1 more source

Lysophosphatidic Acid Induces Migration of Human Lung‐Resident Mesenchymal Stem Cells Through the β‐Catenin Pathway [PDF]

, 2012
Mesenchymal stem cells (MSCs) have been demonstrated to reside in human adult organs. However, mechanisms of migration of these endogenous MSCs within their tissue of origin are not well understood.
Anliker, Badri, Badri, Belperio, Bienz, Bruno, Bullions, Castelino, Cheon, Contos, Fukushima, Haegel, Harris, Hoogduijn, Hoyles, Huelsken, Humphreys, Lai, Lam, Lama, Maeda, Maijenburg, Moolenaar, Nelson, Neth, Novak, Pradere, Pradere, Rivera, Shevtsov, Tager, Tolar, Walker, Yang   +33 more
core   +1 more source

Assessing cognition in autistic youth with and without attention‐deficit/hyperactivity disorder using the NIH Toolbox Cognition Battery: An Environmental influences on Child Health Outcomes‐Wide Cohort Study

JCPP Advances, EarlyView.
Autistic individuals tend to experience difficulties with fluid cognition as found previously, with minimal impact of ADHD. However, there was a notable proportion of autistic individuals with average or superior cognitive performance, highlighting the importance of strength‐based and transdiagnostic research approaches.
Catrina A. Calub, Aisha S. Dickerson, Haozuo Zhao, Robert M. Joseph, Michael O'Shea, Shaikh I. Ahmad, Lisa A. Croen, Sean C. L. Deoni, Viren A. D’Sa, Akhgar Ghassabian, Daphne Koinis‐Mitchell, Leonardo Trasande, Heather Volk, Anna J. Yeo, Irva Hertz‐Picciotto, Julie B. Schweitzer, Marjorie Solomon, for the ECHO Cohort Consortium   +17 more
wiley   +1 more source