Results 91 to 100 of about 18,471 (244)
Nature Communications, 2018 Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-
Nicholas G. Jendzjowsky +8 more
doaj +1 more source
Microscopy Research and Technique, EarlyView.Assessment of Restoring Chemically Damaged Hair Fibers Using Microscopy and Spectroscopy. ABSTRACT This paper analyses hair restoration products currently on the market that treat chemically processed hair. This study measured the restoration of structural integrity in hair samples from both chemically damaged hair (chemically relaxed, bleached, and ...
L. P. A. Mauricio +2 more
wiley +1 more source
Effects of the LPA1 Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice
Frontiers in Molecular Neuroscience, 2019 Lysophosphatidic acid (LPA) is an important bioactive lipid species that functions in intracellular signaling through six characterized G protein-coupled receptors (LPA1-6). Among these receptors, LPA1 is a strong candidate to mediate the central effects
Sara Tabbai +12 more
doaj +1 more source
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background MRI is essential for diagnosing and monitoring neurological diseases. Conventional protocols require multiple sequences to obtain complementary contrasts, increasing scan time, cost, and tolerability. Generating multiple contrasts from a single acquisition may streamline workflow while maintaining clinical utility.
Jeramy Lewis +8 more
wiley +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu +5 more
wiley +1 more source
Gintonin influences the morphology and motility of adult brain neurons via LPA receptors. [PDF]
J Ginseng Res, 2021 Kim DG +8 more
europepmc +1 more source
Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression [PDF]
, 2007 G protein-coupled receptors are key regulators of cellular communication, mediating the efficient coordination of a cell's responses to extracellular stimuli.
New, David C., Wong, Yung Hou
core +1 more source
Advances in GPCRs Associated With Wnt Signaling Within the Auditory System
Medicine Bulletin, EarlyView.ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang +3 more
wiley +1 more source
Autotaxin in Pathophysiology and Pulmonary Fibrosis
Frontiers in Medicine, 2018 Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in idiopathic pulmonary fibrosis (IPF) patients.
Ioanna Ninou +2 more
doaj +1 more source
Identification of a novel class of autotaxin inhibitors through cross-screening [PDF]
, 2015 Three novel series were generated in order to mimic the pharmacophoric features displayed by lead compound AM095, a Lysophosphatidic acid (LPA1) receptor antagonist. Biological evaluation of this array of putative LPA1 antagonists led us to the discovery
Budd, David C. +8 more
core +1 more source