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LPA Receptors: Subtypes and Biological Actions
Annual Review of Pharmacology and Toxicology, 2010Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular signaling molecule by binding to and activating at least five known G protein–coupled receptors (GPCRs): LPA1–LPA5. They are encoded by distinct genes named LPAR1–LPAR5 in humans and Lpar1–Lpar5 in mice.
Deron Herr, Yun Yung, Ji Woong Choi
exaly +3 more sources
Lysophosphatidic acid (LPA) and its receptors
Current Opinion in Pharmacology, 2009Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist.
Deron Herr +2 more
exaly +3 more sources
Prostaglandins & Other Lipid Mediators, 2001
Lysophosphatidic acid (LPA) is a growth factor-like lipid that produces many cellular responses. These responses, including actin cytoskeletal rearrangements, cell proliferation and inhibition of gap junction communication, have been documented in many cell types over the last 2 decades.
N, Fukushima, J, Chun
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Lysophosphatidic acid (LPA) is a growth factor-like lipid that produces many cellular responses. These responses, including actin cytoskeletal rearrangements, cell proliferation and inhibition of gap junction communication, have been documented in many cell types over the last 2 decades.
N, Fukushima, J, Chun
openaire +2 more sources
Autotaxin Facilitates Selective LPA Receptor Signaling
SSRN Electronic Journal, 2022SUMMARY Autotaxin (ATX; ENPP2) produces the lipid mediator lysophosphatidic acid (LPA) that signals through disparate EDG (LPA 1-3 ) and P2Y (LPA 4-6 ) G protein-coupled receptors.
Fernando Salgado-Polo +8 more
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Autotaxin and LPA receptor signaling in cancer
Cancer and Metastasis Reviews, 2011Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) is a lipid mediator that functions as a mitogen and motility factor for many cell types. LPA signals through six specific G protein-coupled receptors, named LPA(1-6), which trigger both overlapping and distinct signaling pathways.
Anna J S, Houben, Wouter H, Moolenaar
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LPA receptor 2 mediates LPA-induced endometrial cancer invasion
Gynecologic Oncology, 2009We have previously shown that lysophosphatidic acid (LPA) promotes the ovarian cancer metastatic cascade. In this study, we evaluated the role of LPA on endometrial cancer invasion.Transient mRNA knockdown was accomplished using pre-designed siRNA duplexes against LPA receptor 2 (LPA2) and human matrix metalloproteinase-7 (MMP-7).
Joanie Mayer, Hope +6 more
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Roles of LPA receptor signaling in breast cancer
Expert Review of Molecular Diagnostics, 2016LPA and its receptors play an important role in mediating malignant behaviors in various cancers, including breast cancer. Aberrant expression of certain LPA receptors in breast cancer suggested that LPA receptors could be potential biomarkers in understanding malignant growth patterns of breast cancer. Further research considering molecular mechanisms
Jizhao, Wang +5 more
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