Results 121 to 130 of about 9,759 (160)

Activity of 2-Substituted Lysophosphatidic Acid (LPA) Analogs at LPA Receptors: Discovery of a LPA1/LPA3 Receptor Antagonist

Molecular Pharmacology, 2001
The physiological implications of lysophosphatidic acid occupancy of individual receptors are largely unknown because selective agonists/antagonists are unavailable currently. The molecular cloning of three high-affinity lysophosphatidic acid receptors, LPA1, LPA2, and LPA3, provides a platform for developing receptor type-selective ligands.
C E, Heise, W L, Santos, A M, Schreihofer, B H, Heasley, Y V, Mukhin, T L, Macdonald, K R, Lynch   +6 more
openaire   +2 more sources

Involvement of LPA signaling via LPA receptor-2 in the promotion of malignant properties in osteosarcoma cells

Experimental Cell Research, 2018
Lysophosphatidic acid (LPA) signaling via G protein-coupled LPA receptors mediates various biological effects in cancer cells. This study aimed to investigate the roles of LPA receptors in the regulation of cellular functions during tumor progression in osteosarcoma cells.
Kaede, Takahashi, Kaori, Fukushima, Kosuke, Tanaka, Kanako, Minami, Kaichi, Ishimoto, Shiho, Otagaki, Nobuyuki, Fukushima, Kanya, Honoki, Toshifumi, Tsujiuchi   +8 more
openaire   +2 more sources

Lysophosphatidic acid (LPA) receptor modulators: Structural features and recent development

European Journal of Medicinal Chemistry, 2021
Gurubasavaraj Pujar, Manisha Singh, Bijo Mathew   +2 more
exaly  

LPA receptor antagonists and uses thereof

2021
BESTVATER BRIAN P, DU ZHIMIN, FARAND JULIE, KAPLAN JOSHUA A, TANG DORIS T, VENKATARAMANI CHANDRASEKAR, WANG PEIYUAN, YANG KIN S, ZAGORSKA ANNA, PHILLIPS BARTON W   +9 more
openaire   +10 more sources

Lysophosphatidic acid (LPA) receptors: Signaling properties and disease relevance

Prostaglandins and Other Lipid Mediators, 2010
Deron Herr, Jerold Chun
exaly  

Homo- and hetero-dimerization of LPA/S1P receptors, OGR1 and GPR4

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2006
Zhiyong Liang, Alexander Zaslavsky, Lisam Shanjukumar Singh   +2 more
exaly  

LPA Receptor

2018
openaire   +1 more source

Lysophosphatidic acid (LPA) and its receptors: Role in airway inflammation and remodeling

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2013
Yutong Zhao, Viswanathan Natarajan
exaly  

Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors

Bioorganic and Medicinal Chemistry Letters, 2004
Junken Aoki, Hiroyuki Arai
exaly  

The lysophosphatidic acid (LPA) receptors their expression and significance in epithelial ovarian neoplasms

Gynecologic Oncology, 2007
Xiaohua Wu
exaly