Results 101 to 110 of about 18,471 (244)

5D Flow MRI Reveals Respiration‐Driven Changes in Blood Flow Energetics in Congenital Heart Disease

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Hemodynamic monitoring is essential for patients with right‐sided congenital heart disease (CHD). Respiration may have an increased impact on pulmonary flow in these patients that cannot be assessed by standard tools including 4D flow MRI. This study uses 5D flow MRI to assess respiratory‐cycle variations in flow energetics in patients
Thara Nallamothu, Elizabeth K. Weiss, Justin Baraboo, Joshua D. Robinson, Cynthia K. Rigsby, Christopher W. Roy, Matthias Stuber, Michael Markl   +7 more
wiley   +1 more source

A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms. [PDF]

, 2017
High lipoprotein (a) [Lp(a)] concentrations are an independent risk factor for cardiovascular outcomes. Concentrations are strongly influenced by apo(a) kringle IV repeat isoforms.
Bergmann, S., Coassin, S., Dähnhardt, D., Erhart, G., Forer, L., Gieger, C., Hunt, S.C., Kedenko, L., Kronenberg, F., Kähönen, M., Lamina, C., Lehtimäki, T., Mack, S., Marques-Vidal, P., Meitinger, T., Paulweber, B., Peters, A., Raitakari, O.T., Ried, J.S., Rueedi, R., Schönherr, S., Seppälä, I., Strauch, K., Stöckl, A., Vollenweider, P., Waeber, G., Yousri, N.A.   +26 more
core   +1 more source

Single‐nucleotide polymorphisms in coronary artery disease: Biological complexity, risk architecture, and implications for precision prevention

Precision Medical Sciences, EarlyView.
This graphical summary highlights the clinical application of single‐nucleotide polymorphisms‐based risk stratification in coronary artery disease. By integrating polygenic risk with clinical assessment, imaging, and preventive strategies, genetic information enables earlier risk identification, optimized screening, and personalized lifestyle and ...
Li Dai, Mosi Chen, Jun Hu, Lei Huang, Ye Yang, Chang Chen, Ying Zhuang, Yan Pan, Bingjun Qian   +8 more
wiley   +1 more source

LPA receptor signaling: pharmacology, physiology, and pathophysiology

Journal of Lipid Research, 2014
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and nonvertebrate organisms that mediates diverse biological actions and demonstrates medicinal relevance. LPA's functional roles are driven by extracellular signaling through at
Yun C. Yung, Nicole C. Stoddard, Jerold Chun   +2 more
doaj   +1 more source

Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells. [PDF]

, 2018
Intracellular Ca2+ and cAMP typically cause opposing effects on airway smooth muscle contraction. Receptors that stimulate these pathways are therapeutic targets in asthma and chronic obstructive pulmonary disease.
Dale, Philippa, Dowling, Mark R, Head, Victoria, Taylor, Colin W   +3 more
core   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

Role of RhoA and rho kinase in lysophosphatidic acid-induced endothelial barrier dysfunction. [PDF]

, 2000
The online version of this article, along with updated information and services, is located on ...
Barrier Dysfunction, E-earterioscler Thromb Vasc Biol, Geerten P. Van Nieuw Amerongen, Geerten P. Van Nieuw Amerongen, Mario A. Vermeer, Mario A. Vermeer, Victor W. M. Van Hinsbergh, Victor W. M. Van Hinsbergh   +7 more
core   +2 more sources

Extrahepatic Gene Editing In Vivo Using Organic Solvent‐Free Lipid Nanoparticles

Small, EarlyView.
This article highlights a novel, organic solvent‐free lipid nanoparticle (LNP) formulation that avoids cholesterol, thereby reducing hepatic accumulation and immune activation. These BLNPs enable potent, flexible, and scalable gene delivery, supporting personalized medicine and diverse nucleic acid applications.
Michael Streiber, Na Liu, Laurianne Simon, Franziska Adermann, Vivien Bachmann, Lucas Gath, Stephanie Hoeppener, Stephanie Schubert, Oliver Werz, Vincent Lapinte, Marie Morille, Michael Bauer, Adrian T. Press, Ulrich S. Schubert, Anja Traeger   +14 more
wiley   +1 more source

PFOA Exposure Elicits Quantitative Lipidomic Changes in the Pancreas in a Mouse Model of Pancreatic Cancer

Environmental Toxicology, EarlyView.
ABSTRACT Pancreatic cancer is the fourth leading cause of cancer deaths in the US and predicted to rise to second by 2030. Several risk factors have been identified as potential contributors to pancreatic cancer development including lifestyle factors and long‐term exposure to occupational and environmental carcinogens.
Barbara A. Hocevar, Lisa M. Kamendulis
wiley   +1 more source

Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors

Journal of Pharmacological Sciences, 2006
.: Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice.
Terumasa Hashimoto, Hisayuki Ohata, Kazuo Honda   +2 more
doaj   +1 more source