Characteristics of Gintonin-Mediated Membrane Depolarization of Pacemaker Activity in Cultured Interstitial Cells of Cajal [PDF]
Cellular Physiology and Biochemistry, 2014 Background/Aims: Ginseng regulates gastrointestinal (GI) motor activity but the underlying components and molecular mechanisms are unknown. We investigated the effect of gintonin, a novel ginseng-derived G protein-coupled lysophosphatidic acid (LPA ...
Byung Joo Kim +11 more
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Gintonin-Enriched Panax ginseng Extract Fraction Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis through DR4/5 Upregulation [PDF]
Current Issues in Molecular BiologyTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising chemotherapeutic agent because of its selective apoptotic action on cancer cells. However, resistance to TRAIL-induced apoptosis remains a challenge in many cancers.
Seongwoo Hong +7 more
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Antimelanoma potential of natural compounds derived from plants: a systematic review of in vivo studies of B16 melanoma and its sublines. [PDF]
Braz J Med Biol ResCutaneous melanoma, a lethal neoplasm originating from epidermal melanocytes, stands out for its resistance to conventional therapies and high metastatic rate.
Gomes BS, Sousa JFM, Mendes RL.
europepmc +3 more sources
Retracted: Oral Administration of Gintonin Protects the Brains of Mice against Aβ-Induced Alzheimer Disease Pathology: Antioxidant and Anti-Inflammatory Effects. [PDF]
Oxid Med Cell Longev, 2023 Oxidative Medicine and Cellular Longevity, Volume 2023, Issue 1, 2023.
Longevity OMAC.
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Gintonin Alleviates HCl/Ethanol- and Indomethacin-Induced Gastric Ulcers in Mice. [PDF]
Int J Mol Sci, 2023 Gintonin, newly extracted from ginseng, is a glycoprotein that acts as an exogenous lysophosphatidic acid (LPA) receptor ligand. This study aimed to demonstrate the in vivo preventive effects of gintonin on gastric damage. ICR mice were randomly assigned to five groups: a normal group (received saline, 0.1 mL/10 g, p.o.); a control group (administered ...
Cho HS +9 more
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Gintonin-Induced Wound-Healing-Related Responses Involve Epidermal-Growth-Factor-like Effects in Keratinocytes. [PDF]
Int J Mol Sci, 2023 Epidermal growth factor (EGF) receptor activation and related downstream signaling pathways are known to be one of the major mechanisms of the proliferation and migration of keratinocytes. The heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors and stimulates keratinocyte proliferation and migration.
Won KJ +5 more
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Wound Healing Effect of Gintonin Involves Lysophosphatidic Acid Receptor/Vascular Endothelial Growth Factor Signaling Pathway in Keratinocytes [PDF]
International Journal of Molecular Sciences, 2021 Sun-Hye Choi, Kyung Jong Won, Rami Lee
exaly +2 more sources
Corrigendum to “Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2”[J Ginseng Res 45(5) September 2021, 575-582] [PDF]
Journal of Ginseng Research, 2023 Mijin Kim +5 more
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Biological evidence of gintonin efficacy in memory disorders
Pharmacological Research, 2021 Gintonin is a novel glycolipoprotein, which has been abundantly found in the root of Korean ginseng. It holds lysophosphatidic acids (LPAs), primarily identified LPA C18:2, and is an exogenous agonist of LPA receptors (LPARs). Gintonin maintains blood-brain barrier integrity, and it has recently been studied in several models of neurodegenerative ...
Md. Jakaria +5 more
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Oxid Med Cell Longev, 2021 The study was aimed at analyzing the protective effects of gintonin in an amyloid beta‐ (Aβ‐) induced Alzheimer’s disease (AD) mouse model. For the development of the Aβ‐induced AD mouse model, the amyloid‐β (Aβ1-42) peptide was stereotaxically injected into the brains of mice. Subsequently, gintonin was administered at a dose of 100 mg/kg/day/per oral
Ikram M +6 more
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