Gintonin-enriched fraction protects against sarcopenic obesity by promoting energy expenditure and attenuating skeletal muscle atrophy in high-fat diet-fed mice [PDF]
Journal of Ginseng Research, 2022 Background: Gintonin-enriched fraction (GEF), a non-saponin fraction of ginseng, is a novel glycolipoprotein rich in hydrophobic amino acids. GEF has recently been shown to regulate lipid metabolism and browning in adipocytes; however, the mechanisms ...
Heegu Jin +3 more
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Gintonin, a Panax ginseng-derived LPA receptor ligand, attenuates kainic acid-induced seizures and neuronal cell death in the hippocampus via anti-inflammatory and anti-oxidant activities [PDF]
Journal of Ginseng Research, 2023 Background: Gintonin (GT), a Panax ginseng-derived lysophosphatidic acid receptor (LPAR) ligand, has positive effects in cultured or animal models for Parkinson's disease, Huntington's disease, and so on. However, the potential therapeutic value of GT in
Jong Hee Choi +4 more
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The Gintonin-Enriched Fraction of Ginseng Regulates Lipid Metabolism and Browning via the cAMP-Protein Kinase a Signaling Pathway in Mice White Adipocytes [PDF]
Biomolecules, 2020 Obesity is a major health concern and is becoming an increasingly serious societal problem worldwide. The browning of white adipocytes has received considerable attention because of its potential protective effect against obesity-related metabolic ...
Kippeum Lee +6 more
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Wound Healing Effect of Gintonin Involves Lysophosphatidic Acid Receptor/Vascular Endothelial Growth Factor Signaling Pathway in Keratinocytes. [PDF]
Int J Mol Sci, 2021 Gintonin, a novel compound of ginseng, is a ligand of the lysophosphatidic acid (LPA) receptor. The in vitro and in vivo skin wound healing effects of gintonin remain unknown.
Choi SH +5 more
europepmc +2 more sources
Corrigendum to “Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2”[J Ginseng Res 45(5) September 2021, 575-582] [PDF]
Journal of Ginseng Research, 2023 Mijin Kim +5 more
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Oxid Med Cell Longev, 2021 The study was aimed at analyzing the protective effects of gintonin in an amyloid beta‐ (Aβ‐) induced Alzheimer’s disease (AD) mouse model. For the development of the Aβ‐induced AD mouse model, the amyloid‐β (Aβ1-42) peptide was stereotaxically injected into the brains of mice. Subsequently, gintonin was administered at a dose of 100 mg/kg/day/per oral
Ikram M +6 more
europepmc +2 more sources
Advanced Functional Materials, Volume 32, Issue 10, March 2, 2022., 2022 The complicated glioblastoma multiforme (GBM) microenvironment and the anatomical features and functionality of the in vivo blood–brain barrier are replicated, and the influence of the GBM microenvironment on tumor behavior and drug delivery are demonstrated. Abstract Physiologically, brain tumors interact with surrounding vascular and glial cells, and
Suyeong Seo +4 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 Pyocyanin (PCN) is a redox‐active secondary metabolite produced by Pseudomonas aeruginosa as its primary virulence factor. Several studies have reported the cytotoxic potential of PCN and its role during infection establishment and progression. Considering its ability to diffuse through biological membranes, it is hypothesized that PCN can gain entry ...
Muhammad Ibrahim Rashid +4 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 Aging is associated with the occurrence of diverse degenerative changes in various tissues and organs and with an increased incidence of neurological disorders, especially neurodegenerative diseases such as Alzheimer’s disease (AD). In recent years, the search for effective components derived from medicinal plants in delaying aging and preventing and ...
Qin Li +7 more
wiley +1 more source
Journal of Ginseng Research, 2021 Background: We recently showed that gintonin, an active ginseng ingredient, exhibits antibrain neurodegenerative disease effects including multiple target mechanisms such as antioxidative stress and antiinflammation via the lysophosphatidic acid (LPA ...
Sung Min Nam +9 more
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