Results 51 to 60 of about 653 (163)
Advanced Functional Materials, Volume 32, Issue 10, March 2, 2022., 2022 The complicated glioblastoma multiforme (GBM) microenvironment and the anatomical features and functionality of the in vivo blood–brain barrier are replicated, and the influence of the GBM microenvironment on tumor behavior and drug delivery are demonstrated. Abstract Physiologically, brain tumors interact with surrounding vascular and glial cells, and
Suyeong Seo +4 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 Pyocyanin (PCN) is a redox‐active secondary metabolite produced by Pseudomonas aeruginosa as its primary virulence factor. Several studies have reported the cytotoxic potential of PCN and its role during infection establishment and progression. Considering its ability to diffuse through biological membranes, it is hypothesized that PCN can gain entry ...
Muhammad Ibrahim Rashid +4 more
wiley +1 more source
Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay [PDF]
, 2015 BACKGROUND: Currently there are no effective treatments for many neurodegenerative diseases. Reliable biomarkers for identifying and stratifying these diseases will be important in the development of future novel therapies.
Bahtia, K +18 more
core +4 more sources
Gintonin stimulates gliotransmitter release in cortical primary astrocytes
Neuroscience Letters, 2015 Lysophosphatidic acid (LPA) is a simple and minor phospholipid, but serves as a lipid-derived neurotransmitter via activation of G protein-coupled LPA receptors. Astrocytes abundantly express LPA receptors and contain gliotransmitters that modulate astrocyte-neuron interactions. Gintonin is a novel ginseng-derived G protein-coupled LPA receptor ligand.
Hyunsook, Kim +9 more
+10 more sources
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 Aging is associated with the occurrence of diverse degenerative changes in various tissues and organs and with an increased incidence of neurological disorders, especially neurodegenerative diseases such as Alzheimer’s disease (AD). In recent years, the search for effective components derived from medicinal plants in delaying aging and preventing and ...
Qin Li +7 more
wiley +1 more source
Ginseng in Hair Growth and Viability [PDF]
, 2021 The hair follicle is the unique organ that has the capacity of undergoing cyclic transformations following periods of growth (anagen), regression (catagen), and rest (telogen) regenerating itself to restart the cycle.
Dionisio L., Lorenzo-Villegas +4 more
core +2 more sources
A review on phyto-nanotechnology for therapy of alzheimer’s disease [PDF]
, 2022 Alzheimer’s disease (AD) is a common chronic neurodegenerative disease (ND) that is mainly investigated nowadays because of its increased incidence and burden on the elderly population. It leads to atrophy of the brain.
R, Gayathri, SL, Manju
core +2 more sources
Effects of Gintonin-Enriched Fraction on Methylmercury-Induced Neurotoxicity and Organ Methylmercury Elimination [PDF]
International Journal of Environmental Research and Public Health, 2020 Gintonin is a newly discovered ingredient of ginseng and plays an exogenous ligand for G protein-coupled lysophosphatidic acid receptors. We previously showed that gintonin exhibits diverse effects from neurotransmitter release to improvement of Alzheimer’s disease-related cognitive dysfunctions.
Hyeon-Joong Kim +7 more
openaire +2 more sources
Ginsenosides act as positive modulators of P2X4 receptors [PDF]
, 2018 We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting as positive allosteric modulators on P2X receptors. ATP-induced responses were measured in stable cell lines overexpressing human P2X4 using a YOPRO-1 dye uptake ...
Asatryan +23 more
core +3 more sources
To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors? [PDF]
, 2020 The family of ligand-gated ion channels known as P2X receptors were discovered several decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research effort has elucidated their roles in regulating a range of physiological and ...
Allum, Elizabeth +3 more
core +1 more source