Results 51 to 60 of about 440 (117)
Ginseng gintonin, aging societies, and geriatric brain diseases
Integrative Medicine Research, 2021 Background: A dramatic increase in aging populations and low birth rates rapidly drive aging societies and increase aging-associated neurodegenerative diseases.
Sun-Hye Choi +8 more
doaj +1 more source
Taxonomic Distribution of Medicinal Plants for Alzheimer’s Disease: A Cue to Novel Drugs
International Journal of Alzheimer’s Disease, Volume 2020, Issue 1, 2020., 2020 Alzheimer’s disease (AD) is a neurodegenerative disorder manifested by decline in memory and mild cognitive impairment leading to dementia. Despite global occurrence of AD, the severity and hence onset of dementia vary among different regions, which was correlated with the customary use of medicinal herbs and exposure level to the causatives.
Muhammad Kamran +9 more
wiley +1 more source
Frontiers in Pharmacology, 2021 Alzheimer’s disease (AD), a neurodegenerative disorder, is a major health concern in the increasingly aged population worldwide. Currently, no clinically effective drug can halt the progression of AD. Panax ginseng C.A. Mey.
Jing Li +9 more
doaj +1 more source
Effects of gintonin-enriched fraction on hippocampal gene expressions
Integrative Medicine Research, 2021 Background: Recently, gintonin and gintonin-enriched fraction (GEF) have been isolated from ginseng, a herbal medicine. Gintonin induces [Ca2+]i transition in cultured hippocampal neurons and stimulates acetylcholine release through LPA receptor ...
Rami Lee +8 more
doaj +1 more source
Mechanisms of Panax ginseng action as an antidepressant
Cell Proliferation, Volume 52, Issue 6, November 2019., 2019 Abstract Objectives Panax ginseng, a well‐known traditional Chinese medicine with multiple pharmacological activities, plays a crucial role in modulating mood disorders. Several recent studies have identified an underlying role of Panax ginseng in the prevention and treatment of depression. However, the cellular and molecular mechanisms remain unclear.
Yang Jin +4 more
wiley +1 more source
Anti‐Inflammatory Activity of Rg3‐Enriched Korean Red Ginseng Extract in Murine Model of Sepsis
Evidence-Based Complementary and Alternative Medicine, Volume 2018, Issue 1, 2018., 2018 Ginseng has therapeutic effects on various bodily disorders ranging from minor inflammation to major cardiovascular diseases. In our study, we explored the anti‐inflammatory effects of Rg3‐enriched red ginseng extract (Rg3‐RGE), a ginsenoside belonging to the panaxadiol group.
Evelyn Saba +7 more
wiley +1 more source
Image_1_Gintonin stimulates dendritic growth in striatal neurons by activating Akt and CREB.TIF [PDF]
, 2022 Gintonin, a glycolipid protein conjugated with lysophosphatidic acid (LPA), is a newly identified compound extracted from Korean ginseng. LPA receptor isotypes exhibit high affinity for gintonin and mediate intracellular calcium signaling in various ...
Seung-Yeol Nah (3968045) +5 more
core +1 more source
Integrative Medicine Research, 2022 Background: Gintonin inhibits β-amyloid production, increases acetylcholine level in the brain, and promotes neurogenesis. We evaluated the efficacy of gintonin-enriched fraction (GEF) in improving the cognitive performance in subjective memory ...
Woo-Jin Lee +7 more
doaj +1 more source
Botanicals as Modulators of Neuroplasticity: Focus on BDNF
Neural Plasticity, Volume 2017, Issue 1, 2017., 2017 The involvement of brain‐derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has been increasingly explored.
Enrico Sangiovanni +4 more
wiley +1 more source
Effects of Gintonin-Enriched Fraction on Methylmercury-Induced Neurotoxicity and Organ Methylmercury Elimination [PDF]
, 2020 Gintonin is a newly discovered ingredient of ginseng and plays an exogenous ligand for G protein-coupled lysophosphatidic acid receptors. We previously showed that gintonin exhibits diverse effects from neurotransmitter release to improvement of ...
Hee-Jung Cho +7 more
core +1 more source