Results 61 to 70 of about 440 (117)

A Role of Ginseng and Its Constituents in the Treatment of Central Nervous System Disorders

Evidence-Based Complementary and Alternative Medicine, Volume 2016, Issue 1, 2016., 2016
Ginseng, a perennial plant belonging to the Panax genus of the Araliaceae family, has been used in China, Korea, and Japan as a traditional herbal medicine for thousands of years. Ginseng is recorded to have exhibited a wide variety of beneficial pharmacological effects and has become a popular and worldwide known health supplement and drug.
Natasya Trivena Rokot, Timothy Sean Kairupan, Kai-Chun Cheng, Joshua Runtuwene, Nova Hellen Kapantow, Marie Amitani, Akinori Morinaga, Haruka Amitani, Akihiro Asakawa, Akio Inui, Hongcai Shang   +10 more
wiley   +1 more source

Proteomics in Traditional Chinese Medicine with an Emphasis on Alzheimer’s Disease

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
In recent years, there has been an increasing worldwide interest in traditional Chinese medicine (TCM). This increasing demand for TCM needs to be accompanied by a deeper understanding of the mechanisms of action of TCM‐based therapy. However, TCM is often described as a concept of Chinese philosophy, which is incomprehensible for Western medical ...
Yanuar Alan Sulistio, Klaus Heese, Xuan Liu   +2 more
wiley   +1 more source

A Novel Korean Red Ginseng Compound Gintonin Inhibited Inflammation by MAPK and NF‐κB Pathways and Recovered the Levels of mir‐34a and mir‐93 in RAW 264.7 Cells

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
The beneficial health promoting effects of ginseng from vitalizing the body to enhancing long life have been well explored very rapidly in the past few years. Up till now many ginsenosides have been discovered for their marvelous therapeutic effects. However during past three years, a novel ginseng compound has been discovered, called gintonin, that ...
Evelyn Saba, Bo Ra Jeon, Da-Hye Jeong, Kija Lee, Youn-Kyoung Goo, Dongmi Kwak, Suk Kim, Seong-Soo Roh, Sung Dae Kim, Seung-Yeol Nah, Man Hee Rhee, Raffaele Capasso   +11 more
wiley   +1 more source

Anti-inflammatory and anti-arthritic effects of Gintonin [PDF]

, 2020
Gintonin is a newly derived glycolipoprotein from the roots of ginseng. The main constituents of Gintonin are lysophosphatidic acid (LPA) and protein.
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Amelioration of muscle wasting by gintonin in cancer cachexia

Neoplasia: An International Journal for Oncology Research, 2021
Cancer cachexia is characterized by systemic inflammation, protein degradation, and loss of skeletal muscle. Despite extensive efforts to develop therapeutics, only few effective treatments are available to protect against cancer cachexia. Here, we found
Yoseph Toni Wijaya, Tania Setiawan, Ita Novita Sari, Seung-Yeol Nah, Hyog Young Kwon   +4 more
doaj   +1 more source

Molecular Mechanisms of Large‐Conductance Ca2+‐Activated Potassium Channel Activation by Ginseng Gintonin

Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013
Gintonin is a unique lysophosphatidic acid (LPA) receptor ligand found in Panax ginseng. Gintonin induces transient [Ca2+]i through G protein‐coupled LPA receptors. Large‐conductance Ca2+‐activated K+ (BKCa) channels are expressed in blood vessels and neurons and play important roles in blood vessel relaxation and attenuation of neuronal excitability ...
S. H. Choi, B. H. Lee, S. H. Hwang, H. J. Kim, S. M. Lee, H. C. Kim, H. W. Rhim, S. Y. Nah, Haruki Yamada   +8 more
wiley   +1 more source

Gintonin-enriched fraction improves sarcopenia by maintaining immune homeostasis in 20- to 24-month-old C57BL/6J mice

Journal of Ginseng Research, 2021
Background: Gintonin-enriched fraction (GEF) is a new non-saponin component glycolipoprotein isolated from ginseng root. This study examined the effect of GEF on age-related sarcopenia in old C57BL/6J mice.
Hyun-Ji Oh, Heegu Jin, Seung-Yeol Nah, Boo-Yong Lee   +3 more
doaj   +1 more source

Plant‐Derived Treatments for Different Types of Muscle Atrophy

Phytotherapy Research, Volume 39, Issue 2, Page 1107-1138, February 2025.
Potential mechanisms of phytoactive compounds in the treatment of muscle atrophy. ABSTRACT With the development of medicine and chemistry, an increasing number of plant‐derived medicines have been shown to exert beneficial therapeutic on the treatment of various physical and psychological diseases. In particular, by using physical chemistry methods, we
Xingpeng Wang, Xiaofu Tang, Yunhui Wang, Shengyin Zhao, Ning Xu, Haoyu Wang, Mingjie Kuang, Shijie Han, Zhensong Jiang, Wen Zhang   +9 more
wiley   +1 more source

Supplementary Material for: Gintonin Attenuates D-Galactose-Induced Hippocampal Senescence by Improving Long-Term Hippocampal Potentiation, Neurogenesis, and Cognitive Functions [PDF]

, 2018
Background: Ginseng has been used to improve brain function and increase longevity. However, little is known about the ingredients of ginseng and molecular mechanisms of its anti-brain aging effects.
Rhim H. (5678189), Kim H.-C. (2879969), Nah S.-Y. (5678195), Cho I.-H. (5678192), Kim H.-J. (4273183), Seo M. (5678183), Choi S.-H. (4599943), Chang B.-J. (5678186), Nam S.M. (5678177), Hwang H. (5678180)   +9 more
core   +1 more source

Neurolipid systems: A new target for the treatment of dementia

Basic &Clinical Pharmacology &Toxicology, Volume 135, Issue 3, Page 225-236, September 2024.
Abstract Neurolipids comprise a diverse class of bioactive lipids that include molecules capable of activating G protein‐coupled receptors, thereby inducing systemic effects that contribute to the maintenance of homeostasis. Dementia, a non‐specific brain disorder characterized by a common set of signs and symptoms, usually arises subsequent to brain ...
Gorka Pereira‐Castelo, Iker Bengoetxea de Tena, Jonatan Martínez‐Gardeazabal, Marta Moreno‐Rodríguez, Estibaliz González de San Román, Iván Manuel, Rafael Rodríguez‐Puertas   +6 more
wiley   +1 more source