Results 61 to 70 of about 250,936 (311)

Mapping deprivation in the East Midlands - implications for policy [PDF]

open access: yes, 2005
This paper summarises the findings from a GIS mapping analysis of deprivation at the small area level in the East Midlands using the Indices of Deprivation 2004 and identifies implications for policy in order to inform the development of the 2006 ...
Greene, AE
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

GIS and urban design [PDF]

open access: yes, 1998
Although urban planning has used computer models and information systems sincethe 1950s and architectural practice has recently restructured to the use of computeraideddesign (CAD) and computer drafting software, urban design has hardly beentouched by ...
Batty, M   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Using Geographic Information Science to Map the Flight of the Regicides in Seventeenth- century New England [PDF]

open access: yes, 2016
In mid-seventeenth century two of the judges who condemned King Charles I of England to death became regicide fugitives when his son came to the throne as Charles II. The two men fled to New England and eluded their Royalist pursuers for twenty years.
Cowley, Steven
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

A Model for Complex Subsidence Causality Interpretation Based on PS-InSAR Cross-Heading Orbits Analysis

open access: yesRemote Sensing, 2019
Urban areas are subject to subsidence due to varying natural and anthropogenic causes. Often, subsidence is interpreted and correlated to a single causal factor; however, subsidence is usually more complex.
Bahaa Mohamadi, Timo Balz, Ali Younes
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Aplikasi Sistem Informasi Geografis Berbasis Web Penyebaran Dana Bantuan Operasional Sekolah [PDF]

open access: yes, 2011
Geographic Information System (GIS) on web mapping form is one of new technology in developing web applications for spatial data processing. This system, is capable of spatial data and attribute data analyzing, thus it makes user easier in using this ...
Hamidi, H. (Hamidi)
core  

Home - About - Disclaimer - Privacy