Results 71 to 80 of about 249,250 (312)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
First insights on the potential of Sentinel-1 for landslides detection [PDF]
, 2016 This paper illustrates the potential of Sentinel-1 for landslide detection, Accepted 23 March 2016 mapping and characterization with the aim of updating inventory maps and monitoring landslide activity.
Barra, Anna +5 more
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Remote Sensing, 2019 Urban areas are subject to subsidence due to varying natural and anthropogenic causes. Often, subsidence is interpreted and correlated to a single causal factor; however, subsidence is usually more complex.
Bahaa Mohamadi, Timo Balz, Ali Younes
doaj +1 more source
Using Geographic Information Science to Map the Flight of the Regicides in Seventeenth- century New England [PDF]
, 2016 In mid-seventeenth century two of the judges who condemned King Charles I of England to death became regicide fugitives when his son came to the throne as Charles II. The two men fled to New England and eluded their Royalist pursuers for twenty years.
Cowley, Steven
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Development of a Conceptual Mapping Standard to Link Building and Geospatial Information
ISPRS International Journal of Geo-Information, 2018 This study introduces the BIM (building information modeling)-GIS (geographic information system) conceptual mapping (B2GM) standard ISO N19166 and proposes a mapping mechanism.
Taewook Kang
doaj +1 more source
UK utility data integration: overcoming schematic heterogeneity [PDF]
, 2008 In this paper we discuss syntactic, semantic and schematic issues which inhibit the integration of utility data in the UK. We then focus on the techniques employed within the VISTA project to overcome schematic heterogeneity.
Beck, A.R. +7 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source