Results 1 to 10 of about 8,250 (205)

GJB2 drives LUAD progression in part via cAMP-mediated M2 macrophage polarization through the PKA-CREB pathway [PDF]

Respiratory Research
Background M2 macrophage polarization is a key driver of lung adenocarcinoma (LUAD) progression, yet its underlying regulatory mechanisms remain unclear.
Yuanhua Liu, Guanghui Liu, Jingjing Mei, Jia Li, Jiming Si, Yan Kang, Jianjun Jin   +6 more
doaj   +3 more sources

GJB2, a novel transcription target of HSF4, confers tumorigenic and metastatic phenotypes and sustains mitochondrial homeostasis in lung adenocarcinoma via the PI3K/AKT pathway [PDF]

Cell Adhesion & Migration
The ion channel gene GJB2 emerges as a therapeutic target for LUAD with significant prognostic value. Herein, the potential mechanisms of GJB2 were investigated. GJB2 expression was analyzed by bioinformatics, RT-qPCR and western blotting.
Qing Hu, Renfan Zhang, Yefeng Zhou, Yang Yang, Hao Zhou, Xin Han, Shengrong Lin   +6 more
doaj   +2 more sources

Comprehensive Analysis and Genetic Insights Into GJB2 c.35delG Mutation-Associated Non-Syndromic Hearing Loss in Morocco. [PDF]

OTO Open
Abstract Objective To assess the prevalence of the GJB2 c.35delG mutation among Moroccan patients with nonsyndromic sensorineural hearing loss (NSHL) and compare it with frequencies reported in other North African populations. Study Design Retrospective cohort study. Setting Multidisciplinary tertiary care hearing loss genetics clinic.
Salman EM, Qabli ME, Soufian L, Mansouri M, Bouzid FZ, Oulghoul O, Chehbouni M, Lakhdar Y, Rochdi Y, Raji A, Aboussair N.   +10 more
europepmc   +2 more sources

Mutation Spectrum and Novel Rare Variants in a Han Chinese Hearing Loss Cohort Using a Tiered Sequencing Strategy. [PDF]

Mol Genet Genomic Med
In a Han Chinese hearing‐loss cohort from Southwest China, a tiered strategy combining targeted hotspot screening and whole‐exome sequencing established molecular diagnoses in 25 patients, including one involving a CDH23 truncating variant not previously reported in Han Chinese patients with hearing loss, and identified a candidate SLC12A2 variant ...
Zhang Y, Yuan S, Wan Y, Li T, Xu L, Yang W, Niu C.   +6 more
europepmc   +2 more sources

GJB2 Promotes HCC Progression by Activating Glycolysis Through Cytoplasmic Translocation and Generating a Suppressive Tumor Microenvironment Based on Single Cell RNA Sequencing

Advanced Science
Despite substantial breakthroughs in the treatment of hepatocellular carcinoma (HCC) in recent years, many patients are diagnosed in the middle or late stages, denying them the option for surgical excision.
Weiwei Tang, Hanyuan Liu, Jinhua Song
exaly   +2 more sources

GJB2 c.109G > A mutation activating IFI27-mediated mitochondrial apoptosis pathway leading to hereditary non-syndromic hearing loss [PDF]

Scientific Reports
Non-syndromic hereditary deafness is a congenital condition that severely impairs the lives of affected children. GJB2 mutations are a common cause of this condition, but their underlying mechanism remains unclear.
Yao Chen, Peiran Zhao, Qingying Lin, Yinglin Zeng, Xiaolong Qiu, Ting Huang, Jianping Tang, Liangpu Xu   +7 more
doaj   +2 more sources

Cell-specific delivery of GJB2 restores auditory function in mouse models of DFNB1 deafness and mediates appropriate expression in NHP cochlea [PDF]

Nature Communications
Mutations in the GJB2 gene cause DFNB1, the most common hereditary hearing loss. GJB2 is expressed by cochlear epithelial cells and fibrocytes, but not by sensory hair cells or neurons.
Maryna V. Ivanchenko, Kevin T. A. Booth, K. Domenica Karavitaki, Larisa M. Antonellis, M. Aurel Nagy, Cole W. Peters, Spencer Price, Yaqiao Li, Anton Lytvyn, Andrew Ward, Eric C. Griffith, Sinisa Hrvatin, Michael E. Greenberg, David P. Corey   +13 more
doaj   +2 more sources

Evaluation of the GJB2 and GJB6 Polymorphisms with Autosomal Recessive Nonsyndromic Hearing Loss in Iranian Population [PDF]

Iranian Journal of Otorhinolaryngology, 2021
Introduction: Hearing loss (HL), with more than 100 gene loci, is the most common sensorineural defects in humans. The mutations in two GJB2 and GJB6 (Gap Junction Protein Beta 2, 6) genes are responsible for nearly 50% of autosomal recessive ...
Somayeh Ebrahimkhani, Golnaz Asaadi Tehrani   +1 more
doaj   +1 more source

Pan-cancer analysis of the prognostic and immunological role of GJB2: a potential target for survival and immunotherapy

Frontiers in Oncology, 2023
BackgroundGJB2 plays an essential role in the growth and progression of several cancers. However, asystematic pan-cancer analysis of GJB2 is lacking. Therefore, in this study, we performed a comprehensive pan-cancer analysis to determine the potential ...
Yuting Jia, Bin Guo, Wenbin Zhang, Feng Wang, Yong Zhang, Quanmao Zhang, Erfeng Li   +6 more
doaj   +1 more source

The prognostic value and biological significance of gap junction beta protein 2 (GJB2 or Cx26) in cervical cancer

Frontiers in Oncology, 2022
ObjectiveTo evaluate the prognostic value and explore the biological significance of gap junction protein beta 2 (GJB2 or Cx26) in cervical cancer (CC).MethodsWe first compared GJB2 expression between CC and normal tissues using public databases and ...
Silu Meng, Silu Meng, Yuhuan Liu, Yuhuan Liu, Xiaoyan Wang, Xue Wu, Xue Wu, Wan Xie, Wan Xie, Xiaoyan Kang, Xiaoyan Kang, Xiaoyu Liu, Xiaoyu Liu, Lili Guo, Lili Guo, Changyu Wang, Changyu Wang   +16 more
doaj   +1 more source