Connexins and the Epithelial Tissue Barrier: A Focus on Connexin 26 [PDF]
Biology, 2021 Epithelial tissue responds rapidly to environmental triggers and is constantly renewed. This tissue is also highly accessible for therapeutic targeting.
Laura Garcia-Vega +3 more
doaj +7 more sources
NMR and structural data for Connexin 32 and Connexin 26 N-terminal peptides [PDF]
Data in Brief, 2016 In this article we present 1H and 13C chemical shift assignments, secondary structural propensity data and normalized temperature coefficient data for N-terminal peptides of Connexin 26 (Cx26), Cx26G12R and Cx32G12R mutants seen in syndromic deafness and
Yuksel Batir +2 more
doaj +7 more sources
Screening of Connexin 26 in Nonsyndromic Hearing Loss [PDF]
International Archives of Otorhinolaryngology, 2015 Introduction The first locus for nonsyndromic autosomal recessive hearing loss is on chromosome 13q11–22. The 35delG mutation is present in 80% of cases in which GJB2 is involved, which makes the study of this mutation very important.
Danielle Moreira +3 more
doaj +9 more sources
Cytomembrane Trafficking Pathways of Connexin 26, 30, and 43 [PDF]
International Journal of Molecular Sciences, 2023 The connexin gene family is the most prevalent gene that contributes to hearing loss. Connexins 26 and 30, encoded by GJB2 and GJB6, respectively, are the most abundantly expressed connexins in the inner ear.
Yu Sun
exaly +3 more sources
Cytoplasmic localization of connexin 26 suppresses transition of β‐catenin into the nucleus in intestinal‐ and mix‐type gastric cancer [PDF]
Annals of Gastroenterological Surgery, 2022 Background Connexin is a basic molecule that forms gap junctions and undergoes localization changes to the cytoplasm in association with carcinogenesis. We aimed to investigate and clarify the significance of cytoplasmic Cx26 expression in gastric cancer.
Nobuhiro Nakazawa +9 more
doaj +2 more sources
Analysis of Genetic Variations in Connexin 26 (GJB2) Gene among Nonsyndromic Hearing Impairment: Familial Study [PDF]
Global Medical Genetics, 2022 Objective The goal of this research was to investigate the gap junction beta 2 (GJB2) gene mutations associated with nonsyndromic hearing loss individuals in North Karnataka, India.
Smita Hegde +5 more
doaj +2 more sources
The Functional Role of CONNEXIN 26 Mutation in Nonsyndromic Hearing Loss, Demonstrated by Zebrafish Connexin 30.3 Homologue Model [PDF]
Cells, 2020 Nonsyndromic hearing loss (NSHL) is of great clinical importance, and mutations in the GJB2 gene and the encoded human CONNEXIN 26 (CX26) protein play important roles in the genetic pathogenesis.
Hsuan-An Su +5 more
doaj +2 more sources
Virally Mediated Connexin 26 Expression in Postnatal Scala Media Significantly and Transiently Preserves Hearing in Connexin 30 Null Mice [PDF]
Frontiers in Cell and Developmental Biology, 2022 Non-sensory cells in the sensory epithelium of the cochlea are connected extensively by gap junctions. Functionally null mutations in GJB6 (encoding Cx30) cause hearing loss in humans. In this study, we injected AAV1-CB7-Gjb2 into the scala media between
Li Zhang +16 more
doaj +2 more sources
Functional hemichannels formed by human connexin 26 expressed in bacteria [PDF]
Bioscience Reports, 2015 Gap-junction channels (GJCs) communicate the cytoplasm of adjacent cells and are formed by head-to-head association of two hemichannels (HCs), one from each of the neighbouring cells.
Mariana C. Fiori +6 more
doaj +2 more sources
Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders [PDF]
Frontiers in Molecular Neuroscience, 2017 Background: Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases.
Liang Xu +45 more
doaj +2 more sources