Results 41 to 50 of about 2,702,233 (230)

Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6

Molecular Therapy: Nucleic Acids, 2012
RNA interference (RNAi) using short interfering RNA (siRNA) is an attractive therapeutic approach for treatment of dominant-negative mutations. Some rare missense dominant-negative mutations lead to congenital-hearing impairments.
Suvarna Dash-Wagh, Stefan Jacob, Staffan Lindberg, Anders Fridberger, Ülo Langel, Mats Ulfendahl   +5 more
doaj   +1 more source

Palmoplantar keratoderma with deafness phenotypic variability in a patient with an inherited GJB2 frameshift variant and novel missense variant

Molecular Genetics & Genomic Medicine, 2021
Background Variants in the GJB2 gene encoding the gap junction protein connexin‐26 (Cx26) can cause autosomal recessive nonsyndromic hearing loss or a variety of phenotypically variable autosomal dominant disorders that effect skin and hearing, such as ...
Emma C. Bedoukian, Stefan Rentas, Cara Skraban, Qing Shao, James Treat, Dale W. Laird, Kathleen E. Sullivan   +6 more
doaj   +1 more source

Comparative functional characterization of novel non-syndromic GJB2 gene variant p.Gly45Arg and lethal syndromic variant p.Gly45Glu [PDF]

PeerJ, 2016
We characterized a novel GJB2 missense variant, c.133G>A, p.Gly45Arg, and compared it with the only other variant at the same amino acid position of the connexin 26 protein (Cx26) reported to date: c.134G>A, p.Gly45Glu.
Juan Rodriguez-Paris, Jörg Waldhaus, Jeenal A. Gordhandas, Lynn Pique, Iris Schrijver   +4 more
doaj   +2 more sources

Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase

Nature Communications, 2018
Connexin proteins are usually considered as tumor suppressors. Here, the authors show that connexin 26 (Cx26) regulates the self-renewal of breast cancer stem cells via a ternary complex with FAK and NANOG.
Praveena S. Thiagarajan, Maksim Sinyuk, Soumya M. Turaga, Erin E. Mulkearns-Hubert, James S. Hale, Vinay Rao, Abeba Demelash, Caner Saygin, Arnab China, Tyler J. Alban, Masahiro Hitomi, Luke A. Torre-Healy, Alvaro G. Alvarado, Awad Jarrar, Andrew Wiechert, Valery Adorno-Cruz, Paul L. Fox, Benjamin C. Calhoun, Jun-Lin Guan, Huiping Liu, Ofer Reizes, Justin D. Lathia   +21 more
doaj   +1 more source

SUPPLEMENTARY MATERIALS: A microtubule-Connexin-43 regulatory link suppresses arrhythmias and cardiac fibrosis in Duchenne muscular dystrophy mice.

, 2022
This is supplementary material of the manuscript entitled: Microtubule-Connexin-43 regulation suppresses arrhythmias and fibrosis in Duchenne muscular dystrophy mice.
Lai-hua Xie (12361865), Natalia Shirokova (12361869), Eric Himelman (12361851), Mauricio Lillo (12361858), Diego Fraidenraich (12360910), George Rodney (12361862), Julie Nouet (12361857), Alexander chong (12361859), Xander Wehrens (12361860), Jorge Contreras (12361870), Delong Zhou (13149067)   +10 more
core   +1 more source

Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells [PDF]

, 2005
During early retinal development, progenitor cells must divide repeatedly to expand the progenitor pool. During G1 and G2 of the cell cycle, progenitor cell nuclei migrate back-and-forth across the proliferative zone in a process termed interkinetic ...
Lüneborg, N.L., Mobbs, Peter, Becker, D.L., Becker, David L., Pearson, R.A., Mobbs, P., Pearson, Rachael A.; id_orcid, Lüneborg, Nanna L.   +7 more
core   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

The Role of Saturated Fatty Acids in Connexin Expression on Endothelial Cells and Eosinophils [PDF]

, 2012
Eotaxin is a potent chemoattractant for eosinophils that becomes elevated in the tissues in response to inflammation and increased adiposity. Therefore, eosinophil migration into adipose tissue should increase in diet-induced obese individuals, yet it ...
Ashack, Kurt Anthony
core  

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source