Results 31 to 40 of about 2,702,233 (230)

Dynamic changes in connexin expression correlate with key events in the wound healing process. [PDF]

, 2003
Wound healing is a complex process requiring communication for the precise co-ordination of different cell types. The role of extracellular communication through growth factors in the wound healing process has been extensively documented, but the role of
Kamaldeep Tamber, Coutinho, Petula, Cindy Qiu, Tamber, Kamaldeep, Becker, David L, Petula Coutinho, Qiu, Cindy, David Becker, Frank, Stefanie, Stefanie Frank   +9 more
core   +1 more source

"Two Novel Mutations and Predominant 35delG Mutation in the Connexin 26 Gene (GJB2) in Iranian Populations" [PDF]

Iranian Journal of Public Health, 2004
Mutations in the GJB2 gene encoding Connexin 26 (Cx26) protein are a major cause for autosomal recessive non syndromic and sporadic deafness in many populations.
"M Hashemzadeh Chaleshtori, M Dowlati, DD Farhud, L Hoghooghi Rad, R Sasanfar A Hoseinipour, M Montazer Zohour, A Tolooi, M Ghadami, HR Pourjafari, MA Oshaghi, MA Patton "   +10 more
doaj   +1 more source

GJB2 gene therapy and conditional deletion reveal developmental stage-dependent effects on inner ear structure and function

Molecular Therapy: Methods & Clinical Development, 2021
Pathogenic variants in GJB2, the gene encoding connexin 26, are the most common cause of autosomal-recessive hereditary deafness. Despite this high prevalence, pathogenic mechanisms leading to GJB2-related deafness are not well understood, and cures are ...
Jingying Guo, Xiaobo Ma, Jennifer M. Skidmore, Jelka Cimerman, Diane M. Prieskorn, Lisa A. Beyer, Donald L. Swiderski, David F. Dolan, Donna M. Martin, Yehoash Raphael   +9 more
doaj   +1 more source

Analysis of GJB2 (Connexin 26) Mutation in Patients with Congenital Non-Syndromic Sensorineural Hearing Loss [PDF]

, 2014
Objective: This study was performed to investigate the GJB2 (connexin 26) gene mutations that are the most frequent cause of sensorineural deafness in patients with congenital non-syndromic sensorineural hearing loss in our region.
Erol Keleş, Turgut Karlidag, Abdulvahap Akyiğit, Emin Kaskalan, Turgut Karlıdağ, Ebru Etem Önalan, İrfan Kaygusuz, Şinasi Yalçın, Sinasi Yalcin   +8 more
core   +1 more source

Overexpression of connexin 26 in carcinoma of the pancreas

Oncology Reports, 2008
Contrary to the previously purported role of gap junction (GJ) associated-protein connexin 26 (Cx26) as a tumor suppressor, increased expression of Cx26 has recently been demonstrated in several human malignancies. Surprisingly, this high expression is reportedly related to poor prognosis in squamous cell lung carcinoma and breast cancer. In this study,
Naganori, Kyo, Hirofumi, Yamamoto, Yutaka, Takeda, Koji, Ezumi, Chew Yee, Ngan, Motokazu, Terayama, Masakazu, Miyake, Ichiro, Takemasa, Masataka, Ikeda, Yuichiro, Doki, Keizo, Dono, Mitsugu, Sekimoto, Hiroshi, Nojima, Morito, Monden   +13 more
openaire   +3 more sources

Molecular Pathology of 6 Novel GJB2 Allelic Variants Detected in Familial and Sporadic Iranian Non Syndromic Hearing Loss Cases [PDF]

Iranian Journal of Public Health, 2008
Background: Mutations of GJB2 gene encoding connexion 26 are the most common cause of hearing loss in many popula­tions. A very wide spectrum of GJB2 gene mutations associated with hearing loss have been detected but pathogenic role has been tested only ...
M Hashemzadeh Chaleshtori , DD Farhud , AH Crosby , E Farrokhi , H Pour Jafari , K Ghatreh Samani , K Safa Chaleshtori , M Kasiri , M Shahrani , GR Mobini, M Mansouri, D Modarresinia, M Jafari   +12 more
doaj   +1 more source

Visfatin reduces gap junction mediated cell-to-cell communication in proximal tubule-derived epithelial cells [PDF]

, 2013
Background/Aims: In the current study we examined if the adipocytokine, visfatin, alters connexinmediated intercellular communication in proximal tubule-derived epithelial cells.
Mark J. Wall, Hills, Claire E., Michael I. Kerr, Paul E. Squires, Claire E. Hills, Kerr, Michael I., Squires, Paul E., Wall, Mark J.   +7 more
core   +1 more source

A novel G21R mutation of the GJB2 gene causes autosomal dominant non-syndromic congenital deafness in a Cuban family

Genetics and Molecular Biology, 2006
Deafness is a complex disorder affecting 1/1000 infants. In developed countries, more than 50% of deafness cases are thought to have a genetic cause. At least 40 loci for dominant non-syndromic deafness and another 30 for recessive non-syndromic deafness
Raquel Rabionet, Estela Morales-Peralta, Núria López-Bigas, Maria Lourdes Arbonés, Xavier Estivill   +4 more
doaj   +1 more source

The Effects of a Mutant Connexin 26 on Epidermal Differentiation [PDF]

Cell Communication & Adhesion, 2003
To elucidate the mode of action of dominant mutant connexins in causing inherited skin diseases, transgenic mice were produced that express the true Vohwinkel syndrome-associated mutant Cx26 (D66H), from a keratin 10 promoter, specifically in the suprabasal epidermal keratinocytes.
George, Bakirtzis, Susan, Jamieson, Trond, Aasen, Sheila, Bryson, Stephen, Forrow, Laurence, Tetley, Malcolm, Finbow, David, Greenhalgh, Malcolm, Hodgins   +8 more
openaire   +2 more sources

Gentamicin affects connexin 26 expression in the cochlear lateral wall

B-ENT, 2012
Gentamicin affects connexin 26 expression in the cochlear lateral wall. Objectives/Hypothesis: Aminoglycosides may decrease the expression of some proteins participating in ion-exchange in the cochlear lateral wall.
P. Hu, R. Lai, D. Xie
doaj   +2 more sources